Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo
Osteosarcoma is a bone tumor with a high incidence in children and adolescents. Chemotherapy for osteosarcoma is limited, and effective targeted drugs are urgently needed to treat osteosarcoma. Exosomes as a natural nano drug delivery platform have been widely studied and proven to have good drug de...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2022.2141921 |
| _version_ | 1798023065149374464 |
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| author | Jinkui Wang Mujie Li Liming Jin Peng Guo Zhaoxia Zhang Chenghao Zhanghuang Xiaojun Tan Tao Mi Jiayan Liu Xin Wu Guanghui Wei Dawei He |
| author_facet | Jinkui Wang Mujie Li Liming Jin Peng Guo Zhaoxia Zhang Chenghao Zhanghuang Xiaojun Tan Tao Mi Jiayan Liu Xin Wu Guanghui Wei Dawei He |
| author_sort | Jinkui Wang |
| collection | DOAJ |
| description | Osteosarcoma is a bone tumor with a high incidence in children and adolescents. Chemotherapy for osteosarcoma is limited, and effective targeted drugs are urgently needed to treat osteosarcoma. Exosomes as a natural nano drug delivery platform have been widely studied and proven to have good drug delivery performance. However, the low production of exosomes hinders its development as a carrier. Exosome mimetics (EMs) as an alternative product of exosomes solve the problem of low production of exosomes and maintain the good performance of exosomes as carriers. In this study, bone marrow mesenchymal stem cells (BMSCs) were sequentially extruded to generate EMs to encapsulate doxorubicin (EM-Dox) to treat osteosarcoma. The results showed that we successfully prepared EMs of BMSC, and EM-Dox was prepared using an active-loading approach. Our engineered EM-Dox demonstrated significantly more potent tumor inhibition activity and fewer side effects than free doxorubicin. This novel biological nanomedicine system provides a promising opportunity to develop novel precision medicine for osteosarcoma. |
| first_indexed | 2024-04-11T17:40:06Z |
| format | Article |
| id | doaj.art-9c6d04c82d114ba7a5ff9986cc30f456 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-04-11T17:40:06Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-9c6d04c82d114ba7a5ff9986cc30f4562022-12-22T04:11:31ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642022-12-012913291330310.1080/10717544.2022.2141921Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivoJinkui Wang0Mujie Li1Liming Jin2Peng Guo3Zhaoxia Zhang4Chenghao Zhanghuang5Xiaojun Tan6Tao Mi7Jiayan Liu8Xin Wu9Guanghui Wei10Dawei He11Department of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, P.R. ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, P.R. ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, P.R. ChinaInstitute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, P.R. ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, P.R. ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, P.R. ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, P.R. ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, P.R. ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, P.R. ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, P.R. ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, Chongqing, P.R. ChinaOsteosarcoma is a bone tumor with a high incidence in children and adolescents. Chemotherapy for osteosarcoma is limited, and effective targeted drugs are urgently needed to treat osteosarcoma. Exosomes as a natural nano drug delivery platform have been widely studied and proven to have good drug delivery performance. However, the low production of exosomes hinders its development as a carrier. Exosome mimetics (EMs) as an alternative product of exosomes solve the problem of low production of exosomes and maintain the good performance of exosomes as carriers. In this study, bone marrow mesenchymal stem cells (BMSCs) were sequentially extruded to generate EMs to encapsulate doxorubicin (EM-Dox) to treat osteosarcoma. The results showed that we successfully prepared EMs of BMSC, and EM-Dox was prepared using an active-loading approach. Our engineered EM-Dox demonstrated significantly more potent tumor inhibition activity and fewer side effects than free doxorubicin. This novel biological nanomedicine system provides a promising opportunity to develop novel precision medicine for osteosarcoma.https://www.tandfonline.com/doi/10.1080/10717544.2022.2141921Bone marrow mesenchymal stem cellsexosome mimeticsdoxorubicinosteosarcomadrug delivery |
| spellingShingle | Jinkui Wang Mujie Li Liming Jin Peng Guo Zhaoxia Zhang Chenghao Zhanghuang Xiaojun Tan Tao Mi Jiayan Liu Xin Wu Guanghui Wei Dawei He Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo Drug Delivery Bone marrow mesenchymal stem cells exosome mimetics doxorubicin osteosarcoma drug delivery |
| title | Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo |
| title_full | Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo |
| title_fullStr | Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo |
| title_full_unstemmed | Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo |
| title_short | Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo |
| title_sort | exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo |
| topic | Bone marrow mesenchymal stem cells exosome mimetics doxorubicin osteosarcoma drug delivery |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2022.2141921 |
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