Spheroids of FAP-Positive Cell Lines as a Model for Screening Drugs That Affect FAP Expression

Spheroids of FAP-Positive Cell Lines as a Model for Screening Drugs That Affect FAP Expression

Fibroblast activation protein has a unique expression profile that manifests mainly in wounds and tumors, which anticipates it as an encouraging and selective target for anticancer therapy. However, research of the therapeutic potential of FAP is limited both by legal restraints when working in vivo...

Full description

Bibliographic Details
Main Authors:	Victor V. Pleshkan, Marina V. Zinovyeva, Dina V. Antonova, Irina V. Alekseenko
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Series:	Biomedicines
Subjects:	fibroblast activation protein cancer-associated fibroblasts 3D spheroids
Online Access:	https://www.mdpi.com/2227-9059/11/7/2017

Similar Items

Cell-specific expression of the FAP gene is regulated by enhancer elements
by: Dina V. Antonova, et al.
Published: (2023-02-01)

Radioligands Targeting Fibroblast Activation Protein (FAP)
by: Thomas Lindner, et al.
Published: (2021-11-01)

FAP-targeted PET imaging in gastrointestinal malignancies: a comprehensive review
by: Ayça Arçay Öztürk, et al.
Published: (2023-08-01)

Characterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma
by: Ming Li, et al.
Published: (2020-12-01)

Efficiency of Promoters of Human Genes <i>FAP</i> and <i>CTGF</i> at Organism Level in a <i>Danio rerio</i> Model
by: Polina I. Selina, et al.
Published: (2023-04-01)

High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes
by: Mairene Coto-Llerena, et al.
Published: (2020-07-01)

Phenotypic Heterogeneity of Cancer Associated Fibroblasts in Cervical Cancer Progression: FAP as a Central Activation Marker
by: Lesly Jazmin Bueno-Urquiza, et al.
Published: (2024-03-01)

Prognostic Interactions between FAP+ Fibroblasts and CD8a+ T Cells in Colon Cancer
by: Mercedes Herrera, et al.
Published: (2020-11-01)

A multifactorial analysis of FAP to regulate gastrointestinal cancers progression
by: Jialing Cai, et al.
Published: (2023-05-01)

Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells: Launching an Attack on Tumor Stroma
by: Bughda R, et al.
Published: (2021-08-01)

Possibility for Transcriptional Targeting of Cancer-Associated Fibroblasts—Limitations and Opportunities
by: Dina V. Antonova, et al.
Published: (2021-03-01)

Fibroblast Activation Protein Alpha (FAPα) in Fibrosis: Beyond a Perspective Marker for Activated Stromal Cells?
by: Nataliya Basalova, et al.
Published: (2023-11-01)

Design, Synthesis and Preclinical Assessment of <sup>99m</sup>Tc-iFAP for In Vivo Fibroblast Activation Protein (FAP) Imaging
by: Diana Trujillo-Benítez, et al.
Published: (2022-01-01)

Altered Tissue and Plasma Levels of Fibroblast Activation Protein-α (FAP) in Renal Tumours
by: Jon Danel Solano-Iturri, et al.
Published: (2020-11-01)

[68Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice
by: Riikka Viitanen, et al.
Published: (2022-07-01)

Heterotypic tumor spheroids: a platform for nanomedicine evaluation
by: Faezeh Vakhshiteh, et al.
Published: (2023-08-01)

Radiation-induced FAP + fibroblasts are involved in keloid recurrence after radiotherapy
by: Yan Gao, et al.
Published: (2022-08-01)

Radiosynthesis and First Preclinical Evaluation of the Novel 11C-Labeled FAP Inhibitor 11C-FAPI: A Comparative Study of 11C-FAPIs and (68Ga) Ga-DOTA-FAPI-04 in a High–FAP-Expression Mouse Model
by: Cheng Wang, et al.
Published: (2022-08-01)

3D heterospecies spheroids of pancreatic stroma and cancer cells demonstrate key phenotypes of pancreatic ductal adenocarcinoma
by: Xinyuan Liu, et al.
Published: (2021-07-01)

Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors
by: Fanfan Li, et al.
Published: (2022-11-01)

Single-Cell RNA Sequencing Unravels Heterogeneity of the Stromal Niche in Cutaneous Melanoma Heterogeneous Spheroids
by: Jiří Novotný, et al.
Published: (2020-11-01)

Searching for Promoters to Drive Stable and Long-Term Transgene Expression in Fibroblasts for Syngeneic Mouse Tumor Models
by: Dina V. Antonova, et al.
Published: (2020-08-01)

TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells
by: Qinrong Ping, et al.
Published: (2023-07-01)

FAP and FAPI-PET/CT in Malignant and Non-Malignant Diseases: A Perfect Symbiosis?
by: Katharina Dendl, et al.
Published: (2021-09-01)

Dataset of voxelwise correlated signal values of ADC, rCBV and FAP-specific PET of 13 Glioblastoma patients
by: Manuel Röhrich, et al.
Published: (2020-08-01)

High expressions of CD10, FAP and GPR77 in CAFs are associated with chemoresistance and worse prognosis in gastric cancer
by: Yilin Tong, et al.
Published: (2022-10-01)

Evaluation of the Radiolabeled Boronic Acid-Based FAP Inhibitor MIP-1232 for Atherosclerotic Plaque Imaging
by: Romana Meletta, et al.
Published: (2015-01-01)

A Biomimetic Polynucleotides–Hyaluronic Acid Hydrogel Promotes the Growth of 3D Spheroid Cultures of Gingival Fibroblasts
by: Maria Teresa Colangelo, et al.
Published: (2023-01-01)

Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs
by: Fiona M. Keane, et al.
Published: (2014-01-01)

Oncogenesis, Microenvironment Modulation and Clinical Potentiality of FAP in Glioblastoma: Lessons Learned from Other Solid Tumors
by: Yixin Shi, et al.
Published: (2021-05-01)

Aspirin Affects MDA-MB-231 Vesicle Production and Their Capacity to Induce Fibroblasts towards a Pro-Invasive State
by: Rafaela de Assiz Louback, et al.
Published: (2023-07-01)

Physical Properties and Cellular Metabolic Characteristics of 3D Spheroids Are Possible Definitive Indices for the Biological Nature of Cancer-Associated Fibroblasts
by: Nami Nishikiori, et al.
Published: (2023-08-01)

Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy
by: Inja Waldhauer, et al.
Published: (2021-01-01)

Is Spheroid a Relevant Model to Address Fibrogenesis in Keloid Research?
by: Zélie Dirand, et al.
Published: (2023-08-01)

The genetics of FAP and FAP-like syndromes.
by: Lipton, L, et al.
Published: (2006)

Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis
by: Shuran Fan, et al.
Published: (2024-02-01)

FAP-Specific Signalling Is an Independent Diagnostic Approach in ACC and Not a Surrogate Marker of MRI Sequences
by: Dawn P. Liew, et al.
Published: (2022-08-01)

Three-dimensional heterotypic colorectal cancer spheroid models for evaluation of drug response
by: Jia Ning Nicolette Yau, et al.
Published: (2023-07-01)

Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy
by: Lisa M Ebert, et al.
Published: (2020-01-01)

Heterotypic Tumor Spheroids in Agitation-Based Cultures: A Scaffold-Free Cell Model That Sustains Long-Term Survival of Endothelial Cells
by: Teresa Franchi-Mendes, et al.
Published: (2021-06-01)