Research progress of inflammatory cytokines in the diagnosis and treatment of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a multifactor, multiple genes disease which involving a variety of mechanisms. Neuroinflammatory response is one of the mechanisms. Many inflammatory cytokines are involved. It may be used in clinic as biomarkers and therapeutic targets. Many proteins encoded b...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2022-06-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-6-964.pdf |
| _version_ | 1827386942913773568 |
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| author | LI Xiao-guang, YANG Lu, LIU Xu-dong, JIA Xin-miao, CHENG Yan-fei, CUI Li-ying |
| author_facet | LI Xiao-guang, YANG Lu, LIU Xu-dong, JIA Xin-miao, CHENG Yan-fei, CUI Li-ying |
| author_sort | LI Xiao-guang, YANG Lu, LIU Xu-dong, JIA Xin-miao, CHENG Yan-fei, CUI Li-ying |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is a multifactor, multiple genes disease which involving a variety of mechanisms. Neuroinflammatory response is one of the mechanisms. Many inflammatory cytokines are involved. It may be used in clinic as biomarkers and therapeutic targets. Many proteins encoded by mutant genes can damage the function of immune system, lead to immune dysfunction and drive the inflammatory response of central nervous system and peripheral immune system. There are many kinds of inflammatory cytokines with great diversification in their levels which influenced by the stage, type and comorbidity of the disease, the results are not consistent at present, and there is no single inflammatory cytokine identified as a specific marker. Inflammatory cytokines have a certain prospect as therapeutic monitoring markers and targets. |
| first_indexed | 2024-03-08T15:53:50Z |
| format | Article |
| id | doaj.art-9c6fba49f8b14d9f896bb67cf1cee4ff |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T15:53:50Z |
| publishDate | 2022-06-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-9c6fba49f8b14d9f896bb67cf1cee4ff2024-01-09T02:51:51ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252022-06-0142696496810.16352/j.issn.1001-6325.2022.06.012Research progress of inflammatory cytokines in the diagnosis and treatment of amyotrophic lateral sclerosisLI Xiao-guang, YANG Lu, LIU Xu-dong, JIA Xin-miao, CHENG Yan-fei, CUI Li-ying01. Department of Neurology; 2. Centre for Medical Science Research,Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730; ;3. Department of Neurology, Linfen People's Hospital, the Seventh Clinical Medical College of Shanxi Medical University, Linfen 041000, ChinaAmyotrophic lateral sclerosis (ALS) is a multifactor, multiple genes disease which involving a variety of mechanisms. Neuroinflammatory response is one of the mechanisms. Many inflammatory cytokines are involved. It may be used in clinic as biomarkers and therapeutic targets. Many proteins encoded by mutant genes can damage the function of immune system, lead to immune dysfunction and drive the inflammatory response of central nervous system and peripheral immune system. There are many kinds of inflammatory cytokines with great diversification in their levels which influenced by the stage, type and comorbidity of the disease, the results are not consistent at present, and there is no single inflammatory cytokine identified as a specific marker. Inflammatory cytokines have a certain prospect as therapeutic monitoring markers and targets.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-6-964.pdfamyotrophic lateral sclerosis|gene variant|inflammatory cytokines |
| spellingShingle | LI Xiao-guang, YANG Lu, LIU Xu-dong, JIA Xin-miao, CHENG Yan-fei, CUI Li-ying Research progress of inflammatory cytokines in the diagnosis and treatment of amyotrophic lateral sclerosis Jichu yixue yu linchuang amyotrophic lateral sclerosis|gene variant|inflammatory cytokines |
| title | Research progress of inflammatory cytokines in the diagnosis and treatment of amyotrophic lateral sclerosis |
| title_full | Research progress of inflammatory cytokines in the diagnosis and treatment of amyotrophic lateral sclerosis |
| title_fullStr | Research progress of inflammatory cytokines in the diagnosis and treatment of amyotrophic lateral sclerosis |
| title_full_unstemmed | Research progress of inflammatory cytokines in the diagnosis and treatment of amyotrophic lateral sclerosis |
| title_short | Research progress of inflammatory cytokines in the diagnosis and treatment of amyotrophic lateral sclerosis |
| title_sort | research progress of inflammatory cytokines in the diagnosis and treatment of amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis|gene variant|inflammatory cytokines |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-6-964.pdf |
| work_keys_str_mv | AT lixiaoguangyangluliuxudongjiaxinmiaochengyanfeicuiliying researchprogressofinflammatorycytokinesinthediagnosisandtreatmentofamyotrophiclateralsclerosis |