<i>TERT</i> Promoter Alterations in Glioblastoma: A Systematic Review
Glioblastoma, the most frequent and aggressive primary malignant tumor, often presents with alterations in the telomerase reverse transcriptase promoter. Telomerase is responsible for the maintenance of telomere length to avoid cell death. Telomere lengthening is required for cancer cell survival an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/5/1147 |
| _version_ | 1797412531560513536 |
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| author | Nathalie Olympios Vianney Gilard Florent Marguet Florian Clatot Frédéric Di Fiore Maxime Fontanilles |
| author_facet | Nathalie Olympios Vianney Gilard Florent Marguet Florian Clatot Frédéric Di Fiore Maxime Fontanilles |
| author_sort | Nathalie Olympios |
| collection | DOAJ |
| description | Glioblastoma, the most frequent and aggressive primary malignant tumor, often presents with alterations in the telomerase reverse transcriptase promoter. Telomerase is responsible for the maintenance of telomere length to avoid cell death. Telomere lengthening is required for cancer cell survival and has led to the investigation of telomerase activity as a potential mechanism that enables cancer growth. The aim of this systematic review is to provide an overview of the available data concerning <i>TERT</i> alterations and glioblastoma in terms of incidence, physiopathological understanding, and potential therapeutic implications. |
| first_indexed | 2024-03-09T05:04:15Z |
| format | Article |
| id | doaj.art-9c71c8a4b25c41bc84b06e44a2ce0179 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T05:04:15Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9c71c8a4b25c41bc84b06e44a2ce01792023-12-03T12:56:59ZengMDPI AGCancers2072-66942021-03-01135114710.3390/cancers13051147<i>TERT</i> Promoter Alterations in Glioblastoma: A Systematic ReviewNathalie Olympios0Vianney Gilard1Florent Marguet2Florian Clatot3Frédéric Di Fiore4Maxime Fontanilles5Cancer Centre Henri Becquerel, Department of Medical Oncology, Rue d’Amiens, 76000 Rouen, FranceNeurosurgery Department, Rouen University Hospital, 1 rue de Germont, 76000 Rouen, FranceDepartment of Pathology, INSERM U1245, Normandie Univ, UNIROUEN and Rouen University Hospital, Normandy Centre for Genomic and Personalized Medicine, 76000 Rouen, FranceCancer Centre Henri Becquerel, Department of Medical Oncology, Rue d’Amiens, 76000 Rouen, FranceCancer Centre Henri Becquerel, Department of Medical Oncology, Rue d’Amiens, 76000 Rouen, FranceCancer Centre Henri Becquerel, Department of Medical Oncology, Rue d’Amiens, 76000 Rouen, FranceGlioblastoma, the most frequent and aggressive primary malignant tumor, often presents with alterations in the telomerase reverse transcriptase promoter. Telomerase is responsible for the maintenance of telomere length to avoid cell death. Telomere lengthening is required for cancer cell survival and has led to the investigation of telomerase activity as a potential mechanism that enables cancer growth. The aim of this systematic review is to provide an overview of the available data concerning <i>TERT</i> alterations and glioblastoma in terms of incidence, physiopathological understanding, and potential therapeutic implications.https://www.mdpi.com/2072-6694/13/5/1147glioblastoma<i>TERT</i>telomerase inhibition |
| spellingShingle | Nathalie Olympios Vianney Gilard Florent Marguet Florian Clatot Frédéric Di Fiore Maxime Fontanilles <i>TERT</i> Promoter Alterations in Glioblastoma: A Systematic Review Cancers glioblastoma <i>TERT</i> telomerase inhibition |
| title | <i>TERT</i> Promoter Alterations in Glioblastoma: A Systematic Review |
| title_full | <i>TERT</i> Promoter Alterations in Glioblastoma: A Systematic Review |
| title_fullStr | <i>TERT</i> Promoter Alterations in Glioblastoma: A Systematic Review |
| title_full_unstemmed | <i>TERT</i> Promoter Alterations in Glioblastoma: A Systematic Review |
| title_short | <i>TERT</i> Promoter Alterations in Glioblastoma: A Systematic Review |
| title_sort | i tert i promoter alterations in glioblastoma a systematic review |
| topic | glioblastoma <i>TERT</i> telomerase inhibition |
| url | https://www.mdpi.com/2072-6694/13/5/1147 |
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