Inherited thrombophilia and recurrent pregnancy loss: a single-center case-control study in North-Western Algeria
Abstract Background Recurrent pregnancy loss (RPL) is a common disorder that affects around 3 to 5% of pregnant women. It has different causes, and in about 50%, it is of unknown etiology. Thrombophilia might increase the risk of RPL by adversely affecting the normal placental vascular function. Our...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-08-01
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| Series: | Egyptian Journal of Medical Human Genetics |
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| Online Access: | http://link.springer.com/article/10.1186/s43042-020-00077-1 |
| _version_ | 1818258707157352448 |
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| author | Ilhem Nassour-Mokhtari Bouchra Loukidi Abdellatif Moussouni Reda Bettioui Riad Benhabib Hafida Merzouk Amaria Aouar Katia Allal-Taouli |
| author_facet | Ilhem Nassour-Mokhtari Bouchra Loukidi Abdellatif Moussouni Reda Bettioui Riad Benhabib Hafida Merzouk Amaria Aouar Katia Allal-Taouli |
| author_sort | Ilhem Nassour-Mokhtari |
| collection | DOAJ |
| description | Abstract Background Recurrent pregnancy loss (RPL) is a common disorder that affects around 3 to 5% of pregnant women. It has different causes, and in about 50%, it is of unknown etiology. Thrombophilia might increase the risk of RPL by adversely affecting the normal placental vascular function. Our study aimed to determine the frequency of factor V Leiden (FVL) and prothrombin G20210A gene mutations in Algerian women with RPL and to correlate their presence with the occurrence of such health’s problem. A total of 80 women with previous fetal losses and 100 age-matched women with no history of fetal loss were recorded. Participants were tested for activated protein C resistance (APCR), protein C (PC), protein S (PS), and antithrombin (AT) deficiencies. The screening of FVL and prothrombin G20210A mutations was also done using a duplex polymerase chain reaction. Results APCR was detected in 6.25% of cases and was absent in controls (p = 0.011). PC and PS deficiencies were documented in 7.5% of patients. FVL was detected in 8.33% of patients and was absent in controls (p = 0.047). Prothrombin G20210A mutation was found in 8.33% of patients compared to 11.11% of controls (p = 0.631). A significant association of FVL mutation with the abortion which occurred in the second trimester was found (p = 0.001). Conclusion There is a significant association between FVL mutation and RPL especially the loss occurring during the second trimester. No correlation was found regarding prothrombin G20210A mutation. |
| first_indexed | 2024-12-12T18:03:49Z |
| format | Article |
| id | doaj.art-9c72bfe508f74e939983c512ae72ea44 |
| institution | Directory Open Access Journal |
| issn | 2090-2441 |
| language | English |
| last_indexed | 2024-12-12T18:03:49Z |
| publishDate | 2020-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj.art-9c72bfe508f74e939983c512ae72ea442022-12-22T00:16:33ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412020-08-012111710.1186/s43042-020-00077-1Inherited thrombophilia and recurrent pregnancy loss: a single-center case-control study in North-Western AlgeriaIlhem Nassour-Mokhtari0Bouchra Loukidi1Abdellatif Moussouni2Reda Bettioui3Riad Benhabib4Hafida Merzouk5Amaria Aouar6Katia Allal-Taouli7Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Faculty of Natural and Life Sciences, Earth and Universe, University of TlemcenLaboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Faculty of Natural and Life Sciences, Earth and Universe, University of TlemcenNational Center for Prehistoric, Anthropological and Historical Research (CNRPAH, Tlemcen’s station)Laboratory of Human Actions’ Valorisation for Protection of Environment and Application in Public Health, University of TlemcenGynecology and Obstetrics Department, Tlemcen’s Teaching HospitalLaboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Faculty of Natural and Life Sciences, Earth and Universe, University of TlemcenLaboratory of Human Actions’ Valorisation for Protection of Environment and Application in Public Health, University of TlemcenLaboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Faculty of Natural and Life Sciences, Earth and Universe, University of TlemcenAbstract Background Recurrent pregnancy loss (RPL) is a common disorder that affects around 3 to 5% of pregnant women. It has different causes, and in about 50%, it is of unknown etiology. Thrombophilia might increase the risk of RPL by adversely affecting the normal placental vascular function. Our study aimed to determine the frequency of factor V Leiden (FVL) and prothrombin G20210A gene mutations in Algerian women with RPL and to correlate their presence with the occurrence of such health’s problem. A total of 80 women with previous fetal losses and 100 age-matched women with no history of fetal loss were recorded. Participants were tested for activated protein C resistance (APCR), protein C (PC), protein S (PS), and antithrombin (AT) deficiencies. The screening of FVL and prothrombin G20210A mutations was also done using a duplex polymerase chain reaction. Results APCR was detected in 6.25% of cases and was absent in controls (p = 0.011). PC and PS deficiencies were documented in 7.5% of patients. FVL was detected in 8.33% of patients and was absent in controls (p = 0.047). Prothrombin G20210A mutation was found in 8.33% of patients compared to 11.11% of controls (p = 0.631). A significant association of FVL mutation with the abortion which occurred in the second trimester was found (p = 0.001). Conclusion There is a significant association between FVL mutation and RPL especially the loss occurring during the second trimester. No correlation was found regarding prothrombin G20210A mutation.http://link.springer.com/article/10.1186/s43042-020-00077-1Recurrent pregnancy lossThrombophiliaFVLAPCR |
| spellingShingle | Ilhem Nassour-Mokhtari Bouchra Loukidi Abdellatif Moussouni Reda Bettioui Riad Benhabib Hafida Merzouk Amaria Aouar Katia Allal-Taouli Inherited thrombophilia and recurrent pregnancy loss: a single-center case-control study in North-Western Algeria Egyptian Journal of Medical Human Genetics Recurrent pregnancy loss Thrombophilia FVL APCR |
| title | Inherited thrombophilia and recurrent pregnancy loss: a single-center case-control study in North-Western Algeria |
| title_full | Inherited thrombophilia and recurrent pregnancy loss: a single-center case-control study in North-Western Algeria |
| title_fullStr | Inherited thrombophilia and recurrent pregnancy loss: a single-center case-control study in North-Western Algeria |
| title_full_unstemmed | Inherited thrombophilia and recurrent pregnancy loss: a single-center case-control study in North-Western Algeria |
| title_short | Inherited thrombophilia and recurrent pregnancy loss: a single-center case-control study in North-Western Algeria |
| title_sort | inherited thrombophilia and recurrent pregnancy loss a single center case control study in north western algeria |
| topic | Recurrent pregnancy loss Thrombophilia FVL APCR |
| url | http://link.springer.com/article/10.1186/s43042-020-00077-1 |
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