An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem Cells
Targeting and killing specific cells discriminately has been the goal of targeted therapy dating back to the era of Paul Ehrlich. The discovery of cancer stem cells has caused a paradigm shift within the cancer field and provided an opportunity to use targeted therapies such as targeted toxins to bi...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-01-01
|
| Series: | Antibodies |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2073-4468/2/1/82 |
| _version_ | 1818836879116599296 |
|---|---|
| author | Daniel A. Vallera Nate N. Waldron |
| author_facet | Daniel A. Vallera Nate N. Waldron |
| author_sort | Daniel A. Vallera |
| collection | DOAJ |
| description | Targeting and killing specific cells discriminately has been the goal of targeted therapy dating back to the era of Paul Ehrlich. The discovery of cancer stem cells has caused a paradigm shift within the cancer field and provided an opportunity to use targeted therapies such as targeted toxins to bind and kill these cells selectively. A number of targeted toxins have been developed against recently identified cancer stem cell markers. In this review we discuss the development and current status of these exciting novel drugs and their potential use to combat drug-refractory relapse. |
| first_indexed | 2024-12-19T03:13:37Z |
| format | Article |
| id | doaj.art-9c73de551190493ca95535afbd8ab624 |
| institution | Directory Open Access Journal |
| issn | 2073-4468 |
| language | English |
| last_indexed | 2024-12-19T03:13:37Z |
| publishDate | 2013-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibodies |
| spelling | doaj.art-9c73de551190493ca95535afbd8ab6242022-12-21T20:37:57ZengMDPI AGAntibodies2073-44682013-01-0121829210.3390/antib2010082An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem CellsDaniel A. ValleraNate N. WaldronTargeting and killing specific cells discriminately has been the goal of targeted therapy dating back to the era of Paul Ehrlich. The discovery of cancer stem cells has caused a paradigm shift within the cancer field and provided an opportunity to use targeted therapies such as targeted toxins to bind and kill these cells selectively. A number of targeted toxins have been developed against recently identified cancer stem cell markers. In this review we discuss the development and current status of these exciting novel drugs and their potential use to combat drug-refractory relapse.http://www.mdpi.com/2073-4468/2/1/82cancer stem cellstargeted toxinsimmunotoxinsCD133EpCAMCD123CD44 |
| spellingShingle | Daniel A. Vallera Nate N. Waldron An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem Cells Antibodies cancer stem cells targeted toxins immunotoxins CD133 EpCAM CD123 CD44 |
| title | An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem Cells |
| title_full | An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem Cells |
| title_fullStr | An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem Cells |
| title_full_unstemmed | An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem Cells |
| title_short | An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem Cells |
| title_sort | old idea tackling a new problem targeted toxins specific for cancer stem cells |
| topic | cancer stem cells targeted toxins immunotoxins CD133 EpCAM CD123 CD44 |
| url | http://www.mdpi.com/2073-4468/2/1/82 |
| work_keys_str_mv | AT danielavallera anoldideatacklinganewproblemtargetedtoxinsspecificforcancerstemcells AT natenwaldron anoldideatacklinganewproblemtargetedtoxinsspecificforcancerstemcells AT danielavallera oldideatacklinganewproblemtargetedtoxinsspecificforcancerstemcells AT natenwaldron oldideatacklinganewproblemtargetedtoxinsspecificforcancerstemcells |