Effect of lemongrass gel against Candida albicans in rat model of oral candidiasis
Candidiasis is the most prevalent fungal infection found in the oral cavity. Current interventions for oral fungal infections are not very successful and require a long treatment period. This research aims to study the in vitro and in vivo effects of lemongrass oil on Candida albicans. The antifung...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2020-04-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | https://rdo.psu.ac.th/sjstweb/journal/42-2/8.pdf |
| _version_ | 1818503510319169536 |
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| author | Suwimol Taweechaisupapong Thidarut Boonmars Panitta Satthanakul Visarut Chatchanayuenyong Suwara Nitinon Unthika Soodtoetong Watcharapon Thipsongkroh Watcharee Khunkitti |
| author_facet | Suwimol Taweechaisupapong Thidarut Boonmars Panitta Satthanakul Visarut Chatchanayuenyong Suwara Nitinon Unthika Soodtoetong Watcharapon Thipsongkroh Watcharee Khunkitti |
| author_sort | Suwimol Taweechaisupapong |
| collection | DOAJ |
| description | Candidiasis is the most prevalent fungal infection found in the oral cavity. Current interventions for oral fungal infections are not very successful and require a long treatment period. This research aims to study the in vitro and in vivo effects of
lemongrass oil on Candida albicans. The antifungal activities of lemongrass oil towards C. albicans were determined by broth
microdilution and time-kill assay. A lemongrass gel was formulated and its antifungal potential was evaluated in the rat model.
The results from the in vitro study revealed that lemongrass oil possesses potent antifungal activity. In the in vivo study, 15
Sprague-Dawley rats were divided into 3 groups and treated with gel base, lemongrass gel, and Daktarin® gel. After 2 weeks, the
quantity of C. albicans in the oral tissues of lemongrass gel- and Daktarin®-treated rats was significantly lower than the gel base
group (P<0.05). The C. albicans colony-forming units of the lemongrass-treated rats was insignificantly different from the rats
treated with Daktarin® gel. The data indicated that lemongrass and Daktarin® gel achieved comparable efficacy against C.
albicans in a rat model which suggests the potential use of lemongrass gel for oral candidiasis. |
| first_indexed | 2024-12-10T21:24:56Z |
| format | Article |
| id | doaj.art-9c74134bb5bd418f86f08c7983d09ea9 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-12-10T21:24:56Z |
| publishDate | 2020-04-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-9c74134bb5bd418f86f08c7983d09ea92022-12-22T01:33:01ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952020-04-0142229930410.14456/sjst-psu.2020.39Effect of lemongrass gel against Candida albicans in rat model of oral candidiasisSuwimol Taweechaisupapong0Thidarut Boonmars1Panitta Satthanakul2Visarut Chatchanayuenyong3Suwara Nitinon4Unthika Soodtoetong5Watcharapon Thipsongkroh6Watcharee Khunkitti7Biofilm Research group, Faculty of Dentistry, Khon Kaen University, Mueang, Khon Kaen, 40002 ThailandDepartment of Parasitology and Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Mueang, Khon Kaen, 40002 ThailandBiofilm Research group, Faculty of Dentistry, Khon Kaen University, Mueang, Khon Kaen, 40002 ThailandBiofilm Research group, Faculty of Dentistry, Khon Kaen University, Mueang, Khon Kaen, 40002 ThailandBiofilm Research group, Faculty of Dentistry, Khon Kaen University, Mueang, Khon Kaen, 40002 ThailandBiofilm Research group, Faculty of Dentistry, Khon Kaen University, Mueang, Khon Kaen, 40002 ThailandBiofilm Research group, Faculty of Dentistry, Khon Kaen University, Mueang, Khon Kaen, 40002 ThailandBiofilm Research group, Faculty of Dentistry, Khon Kaen University, Mueang, Khon Kaen, 40002 ThailandCandidiasis is the most prevalent fungal infection found in the oral cavity. Current interventions for oral fungal infections are not very successful and require a long treatment period. This research aims to study the in vitro and in vivo effects of lemongrass oil on Candida albicans. The antifungal activities of lemongrass oil towards C. albicans were determined by broth microdilution and time-kill assay. A lemongrass gel was formulated and its antifungal potential was evaluated in the rat model. The results from the in vitro study revealed that lemongrass oil possesses potent antifungal activity. In the in vivo study, 15 Sprague-Dawley rats were divided into 3 groups and treated with gel base, lemongrass gel, and Daktarin® gel. After 2 weeks, the quantity of C. albicans in the oral tissues of lemongrass gel- and Daktarin®-treated rats was significantly lower than the gel base group (P<0.05). The C. albicans colony-forming units of the lemongrass-treated rats was insignificantly different from the rats treated with Daktarin® gel. The data indicated that lemongrass and Daktarin® gel achieved comparable efficacy against C. albicans in a rat model which suggests the potential use of lemongrass gel for oral candidiasis.https://rdo.psu.ac.th/sjstweb/journal/42-2/8.pdfcandidiasiscandida albicanslemongrass gelrat model |
| spellingShingle | Suwimol Taweechaisupapong Thidarut Boonmars Panitta Satthanakul Visarut Chatchanayuenyong Suwara Nitinon Unthika Soodtoetong Watcharapon Thipsongkroh Watcharee Khunkitti Effect of lemongrass gel against Candida albicans in rat model of oral candidiasis Songklanakarin Journal of Science and Technology (SJST) candidiasis candida albicans lemongrass gel rat model |
| title | Effect of lemongrass gel against Candida albicans in rat model of oral candidiasis |
| title_full | Effect of lemongrass gel against Candida albicans in rat model of oral candidiasis |
| title_fullStr | Effect of lemongrass gel against Candida albicans in rat model of oral candidiasis |
| title_full_unstemmed | Effect of lemongrass gel against Candida albicans in rat model of oral candidiasis |
| title_short | Effect of lemongrass gel against Candida albicans in rat model of oral candidiasis |
| title_sort | effect of lemongrass gel against candida albicans in rat model of oral candidiasis |
| topic | candidiasis candida albicans lemongrass gel rat model |
| url | https://rdo.psu.ac.th/sjstweb/journal/42-2/8.pdf |
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