Preoperative Visualized Ultrasound Assessment of the Recurrent Laryngeal Nerve in Thyroid Cancer Surgery: Reliability and Risk Features by Imaging
Yushuang He,1 Zhihui Li,2 Yujia Yang,1 Jianyong Lei,2 Yulan Peng1 1Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan Province, 610041, People’s Republic of China; 2Department of Thyroid Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province,...
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| Language: | English |
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Dove Medical Press
2021-09-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/preoperative-visualized-ultrasound-assessment-of-the-recurrent-larynge-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1818608646212288512 |
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| author | He Y Li Z Yang Y Lei J Peng Y |
| author_facet | He Y Li Z Yang Y Lei J Peng Y |
| author_sort | He Y |
| collection | DOAJ |
| description | Yushuang He,1 Zhihui Li,2 Yujia Yang,1 Jianyong Lei,2 Yulan Peng1 1Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan Province, 610041, People’s Republic of China; 2Department of Thyroid Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, 610041, People’s Republic of ChinaCorrespondence: Yulan PengDepartment of Ultrasound, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, People’s Republic of ChinaTel +8618980601606Fax +86 28 8542 3192Email yulanpeng520@126.comZhihui LiDepartment of Thyroid Surgery, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, People’s Republic of ChinaTel +8618980602027Fax +86 28 8542 2933Email rockoliver@vip.sina.comBackground: Preoperative identification and visualization of tumor infiltration of the recurrent laryngeal nerve (RLN) in patients with thyroid cancer is important. The purpose of our study was to evaluate the reliability and feasibility of preoperative assessment by ultrasound and to identify ultrasound imaging features potentially associated with tumor infiltration of the RLN.Methods: In this prospective study, patients undergoing thyroid cancer surgery at our institution between August 2020 and January 2021 were included, and preoperative ultrasound visualization of the RLN and thyroid lesions was performed. RLN infiltration was also confirmed surgically in all cases. Five patients with enlarged lymph nodes were selected to undergo injection of carbon nanoparticles to confirm the correctness of RLN identification by preoperative ultrasound. The repeatability of RLN assessment by ultrasound was evaluated by comparing the correlation between pre- and intraoperative, intra- and inter-group assessments. Parameters of normal RLNs according to age, sex, and body mass index were established. Finally, ultrasound imaging features of patients with RLN tumor infiltration were analyzed to identify potential risk predictors.Results: According to the ultrasonic assessment, RLNs of 70 patients appeared normal, while 14 of those patients appeared to be infiltrated by tumors. During surgery, the 70 cases of normal RLNs were confirmed, but only 8 of the 14 suspected cases of infiltration were confirmed. In all five patients injected with carbon nanoparticles, the location of RLNs adjacent to the marked lymph nodes observed by surgeons corresponded to the RLN location identified by preoperative ultrasound. The repeatability of RLN estimation varied from moderate to excellent. There were no significant differences in cross-sectional area, width, or thickness of normal RLNs according to age, sex, or body mass index. Indistinct margin with tumor, incontinuous shape as ultrasound features by the analysis of patients with surgically confirmed RLN infiltration were associated with tumor invasion.Conclusion: We show that preoperative ultrasound can be applied to visualize the RLN and may help predict tumor infiltration of the RLN.Keywords: recurrent laryngeal nerve, ultrasound, visualization, reliability |
| first_indexed | 2024-12-16T14:45:57Z |
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| id | doaj.art-9c78d5a1baea42debe8bc2af1edbebfa |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-16T14:45:57Z |
| publishDate | 2021-09-01 |
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| series | Cancer Management and Research |
| spelling | doaj.art-9c78d5a1baea42debe8bc2af1edbebfa2022-12-21T22:27:47ZengDove Medical PressCancer Management and Research1179-13222021-09-01Volume 137057706668714Preoperative Visualized Ultrasound Assessment of the Recurrent Laryngeal Nerve in Thyroid Cancer Surgery: Reliability and Risk Features by ImagingHe YLi ZYang YLei JPeng YYushuang He,1 Zhihui Li,2 Yujia Yang,1 Jianyong Lei,2 Yulan Peng1 1Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan Province, 610041, People’s Republic of China; 2Department of Thyroid Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, 610041, People’s Republic of ChinaCorrespondence: Yulan PengDepartment of Ultrasound, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, People’s Republic of ChinaTel +8618980601606Fax +86 28 8542 3192Email yulanpeng520@126.comZhihui LiDepartment of Thyroid Surgery, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, People’s Republic of ChinaTel +8618980602027Fax +86 28 8542 2933Email rockoliver@vip.sina.comBackground: Preoperative identification and visualization of tumor infiltration of the recurrent laryngeal nerve (RLN) in patients with thyroid cancer is important. The purpose of our study was to evaluate the reliability and feasibility of preoperative assessment by ultrasound and to identify ultrasound imaging features potentially associated with tumor infiltration of the RLN.Methods: In this prospective study, patients undergoing thyroid cancer surgery at our institution between August 2020 and January 2021 were included, and preoperative ultrasound visualization of the RLN and thyroid lesions was performed. RLN infiltration was also confirmed surgically in all cases. Five patients with enlarged lymph nodes were selected to undergo injection of carbon nanoparticles to confirm the correctness of RLN identification by preoperative ultrasound. The repeatability of RLN assessment by ultrasound was evaluated by comparing the correlation between pre- and intraoperative, intra- and inter-group assessments. Parameters of normal RLNs according to age, sex, and body mass index were established. Finally, ultrasound imaging features of patients with RLN tumor infiltration were analyzed to identify potential risk predictors.Results: According to the ultrasonic assessment, RLNs of 70 patients appeared normal, while 14 of those patients appeared to be infiltrated by tumors. During surgery, the 70 cases of normal RLNs were confirmed, but only 8 of the 14 suspected cases of infiltration were confirmed. In all five patients injected with carbon nanoparticles, the location of RLNs adjacent to the marked lymph nodes observed by surgeons corresponded to the RLN location identified by preoperative ultrasound. The repeatability of RLN estimation varied from moderate to excellent. There were no significant differences in cross-sectional area, width, or thickness of normal RLNs according to age, sex, or body mass index. Indistinct margin with tumor, incontinuous shape as ultrasound features by the analysis of patients with surgically confirmed RLN infiltration were associated with tumor invasion.Conclusion: We show that preoperative ultrasound can be applied to visualize the RLN and may help predict tumor infiltration of the RLN.Keywords: recurrent laryngeal nerve, ultrasound, visualization, reliabilityhttps://www.dovepress.com/preoperative-visualized-ultrasound-assessment-of-the-recurrent-larynge-peer-reviewed-fulltext-article-CMARrecurrent laryngeal nerveultrasoundvisualizationreliability. |
| spellingShingle | He Y Li Z Yang Y Lei J Peng Y Preoperative Visualized Ultrasound Assessment of the Recurrent Laryngeal Nerve in Thyroid Cancer Surgery: Reliability and Risk Features by Imaging Cancer Management and Research recurrent laryngeal nerve ultrasound visualization reliability. |
| title | Preoperative Visualized Ultrasound Assessment of the Recurrent Laryngeal Nerve in Thyroid Cancer Surgery: Reliability and Risk Features by Imaging |
| title_full | Preoperative Visualized Ultrasound Assessment of the Recurrent Laryngeal Nerve in Thyroid Cancer Surgery: Reliability and Risk Features by Imaging |
| title_fullStr | Preoperative Visualized Ultrasound Assessment of the Recurrent Laryngeal Nerve in Thyroid Cancer Surgery: Reliability and Risk Features by Imaging |
| title_full_unstemmed | Preoperative Visualized Ultrasound Assessment of the Recurrent Laryngeal Nerve in Thyroid Cancer Surgery: Reliability and Risk Features by Imaging |
| title_short | Preoperative Visualized Ultrasound Assessment of the Recurrent Laryngeal Nerve in Thyroid Cancer Surgery: Reliability and Risk Features by Imaging |
| title_sort | preoperative visualized ultrasound assessment of the recurrent laryngeal nerve in thyroid cancer surgery reliability and risk features by imaging |
| topic | recurrent laryngeal nerve ultrasound visualization reliability. |
| url | https://www.dovepress.com/preoperative-visualized-ultrasound-assessment-of-the-recurrent-larynge-peer-reviewed-fulltext-article-CMAR |
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