Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in Osteoarthritis Patients: Results from NHANES III and NHANES 2001–2018
Objectives: The role of Vitamin D (VD) in calcium balance and bone health makes VD a vital factor in osteoarthritis (OA). Studies that have evaluated the effect of VD on OA patients have mainly been performed on a short-term basis. In this analysis, we aimed to evaluate whether VD was associated wit...
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2022-11-01
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author | Jing Wang Jiayao Fan Ye Yang Sara Moazzen Dingwan Chen Lingling Sun Fan He Yingjun Li |
author_facet | Jing Wang Jiayao Fan Ye Yang Sara Moazzen Dingwan Chen Lingling Sun Fan He Yingjun Li |
author_sort | Jing Wang |
collection | DOAJ |
description | Objectives: The role of Vitamin D (VD) in calcium balance and bone health makes VD a vital factor in osteoarthritis (OA). Studies that have evaluated the effect of VD on OA patients have mainly been performed on a short-term basis. In this analysis, we aimed to evaluate whether VD was associated with mortality, a long-term outcome, in OA patients. Methods: Participants with self-reported OA from NHANES III and NHANES 2001–2018 were included. Associations of 25(OH)D concentrations with mortality risk were assessed continuously using restricted cubic splines and by categories (i.e., <25.0, 25.0–49.9, 50.0–74.9, and ≥75.0 nmol/L) using the Cox regression model. Sensitivity and stratified analyses were performed to evaluate the robustness of the results. Results: A total of 4570 patients were included, of which 1388 died by 31 December 2019. An L-shaped association was observed between 25(OH)D concentrations and all-cause mortality, whereas an inverse association was found for cardiovascular disease (CVD) mortality. The adjusted hazard ratios (95% confidence intervals) across four categories were 1.00 (reference), 0.49 (0.31, 0.75), 0.45 (0.29, 0.68), and 0.43 (0.27, 0.69) for all-cause mortality and 1.00 (reference), 0.28 (0.14, 0.59), 0.25 (0.12, 0.51), and 0.24 (0.11, 0.49) for CVD-specific mortality; no significant associations were found for cancer-specific mortality. Similar results were observed when stratified and sensitivity analyses were performed. Conclusions: Compared with patients with insufficient or deficient serum 25(OH)D, those with sufficient 25(OH)D concentrations had a lower risk of all-cause and CVD mortality, supporting a beneficial role of VD on a long-term basis. |
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spelling | doaj.art-9c7bfda5434d49a4b5b5bb98b95bccea2023-11-24T06:14:39ZengMDPI AGNutrients2072-66432022-11-011421462910.3390/nu14214629Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in Osteoarthritis Patients: Results from NHANES III and NHANES 2001–2018Jing Wang0Jiayao Fan1Ye Yang2Sara Moazzen3Dingwan Chen4Lingling Sun5Fan He6Yingjun Li7Department of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou 310053, ChinaSchool of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310030, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou 310053, ChinaMolecular Epidemiology Research Group, Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft, 13125 Berlin, GermanyPrimary Health Research Center of Zhejiang Province, Hangzhou Medical College, Hangzhou 310053, ChinaDepartment of Orthopaedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, ChinaZhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou 310053, ChinaObjectives: The role of Vitamin D (VD) in calcium balance and bone health makes VD a vital factor in osteoarthritis (OA). Studies that have evaluated the effect of VD on OA patients have mainly been performed on a short-term basis. In this analysis, we aimed to evaluate whether VD was associated with mortality, a long-term outcome, in OA patients. Methods: Participants with self-reported OA from NHANES III and NHANES 2001–2018 were included. Associations of 25(OH)D concentrations with mortality risk were assessed continuously using restricted cubic splines and by categories (i.e., <25.0, 25.0–49.9, 50.0–74.9, and ≥75.0 nmol/L) using the Cox regression model. Sensitivity and stratified analyses were performed to evaluate the robustness of the results. Results: A total of 4570 patients were included, of which 1388 died by 31 December 2019. An L-shaped association was observed between 25(OH)D concentrations and all-cause mortality, whereas an inverse association was found for cardiovascular disease (CVD) mortality. The adjusted hazard ratios (95% confidence intervals) across four categories were 1.00 (reference), 0.49 (0.31, 0.75), 0.45 (0.29, 0.68), and 0.43 (0.27, 0.69) for all-cause mortality and 1.00 (reference), 0.28 (0.14, 0.59), 0.25 (0.12, 0.51), and 0.24 (0.11, 0.49) for CVD-specific mortality; no significant associations were found for cancer-specific mortality. Similar results were observed when stratified and sensitivity analyses were performed. Conclusions: Compared with patients with insufficient or deficient serum 25(OH)D, those with sufficient 25(OH)D concentrations had a lower risk of all-cause and CVD mortality, supporting a beneficial role of VD on a long-term basis.https://www.mdpi.com/2072-6643/14/21/4629Vitamin DosteoarthritismortalityNHANES |
spellingShingle | Jing Wang Jiayao Fan Ye Yang Sara Moazzen Dingwan Chen Lingling Sun Fan He Yingjun Li Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in Osteoarthritis Patients: Results from NHANES III and NHANES 2001–2018 Nutrients Vitamin D osteoarthritis mortality NHANES |
title | Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in Osteoarthritis Patients: Results from NHANES III and NHANES 2001–2018 |
title_full | Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in Osteoarthritis Patients: Results from NHANES III and NHANES 2001–2018 |
title_fullStr | Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in Osteoarthritis Patients: Results from NHANES III and NHANES 2001–2018 |
title_full_unstemmed | Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in Osteoarthritis Patients: Results from NHANES III and NHANES 2001–2018 |
title_short | Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in Osteoarthritis Patients: Results from NHANES III and NHANES 2001–2018 |
title_sort | vitamin d status and risk of all cause and cause specific mortality in osteoarthritis patients results from nhanes iii and nhanes 2001 2018 |
topic | Vitamin D osteoarthritis mortality NHANES |
url | https://www.mdpi.com/2072-6643/14/21/4629 |
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