Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy
Abstract Objective Typical aging is associated with gradual cognitive decline and changes in brain structure. The observation that cognitive performance in mesial temporal lobe epilepsy (TLE) patients diverges from controls early in life with subsequent decline running in parallel would suggest an i...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51793 |
| _version_ | 1797778114143584256 |
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| author | Clarissa Lin Yasuda Luciana Ramalho Pimentel‐Silva Guilherme Coco Beltramini Min Liu Brunno Machado de Campos Ana Carolina Coan Christian Beaulieu Fernando Cendes Donald William Gross |
| author_facet | Clarissa Lin Yasuda Luciana Ramalho Pimentel‐Silva Guilherme Coco Beltramini Min Liu Brunno Machado de Campos Ana Carolina Coan Christian Beaulieu Fernando Cendes Donald William Gross |
| author_sort | Clarissa Lin Yasuda |
| collection | DOAJ |
| description | Abstract Objective Typical aging is associated with gradual cognitive decline and changes in brain structure. The observation that cognitive performance in mesial temporal lobe epilepsy (TLE) patients diverges from controls early in life with subsequent decline running in parallel would suggest an initial insult but does not support accelerated decline secondary to seizures. Whether TLE patients demonstrate similar trajectories of age‐related gray (GM) and white matter (WM) changes as compared to healthy controls remains uncertain. Methods 3D T1‐weighted and diffusion tensor images were acquired at a single site in 170 TLE patients (aged 23–74 years) with MRI signs of unilateral hippocampal sclerosis (HS, 77 right) and 111 healthy controls (aged 26–80 years). Global brain (GM, WM, total brain, and cerebrospinal fluid) and regional volumes (ipsi‐ and contralateral hippocampi), and fractional anisotropy (FA) of 10 tracts (three portions of corpus callosum, inferior longitudinal, inferior fronto‐occipital and uncinate fasciculi, body of fornix, dorsal and parahippocampal‐cingulum, and corticospinal tract) were compared between groups as a function of age. Results There were significant reductions of global brain and hippocampi volumes (greatest ipsilateral to HS), and FA of all 10 tracts in TLE versus controls. For TLE patients, regression lines run in parallel to those from controls for brain volumes and FA (for all tracts except the parahippocampal‐cingulum and corticospinal tract) versus age across the adult lifespan. Interpretation These results imply a developmental hindrance occurring earlier in life (likely in childhood/neurodevelopmental stages) rather than accelerated atrophy/degeneration of most brain structures herein analyzed in patients with TLE. |
| first_indexed | 2024-03-12T23:13:39Z |
| format | Article |
| id | doaj.art-9c80619f6c5c441d81f3cfa3b8d7693b |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-03-12T23:13:39Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-9c80619f6c5c441d81f3cfa3b8d7693b2023-07-17T17:19:00ZengWileyAnnals of Clinical and Translational Neurology2328-95032023-07-011071106111810.1002/acn3.51793Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsyClarissa Lin Yasuda0Luciana Ramalho Pimentel‐Silva1Guilherme Coco Beltramini2Min Liu3Brunno Machado de Campos4Ana Carolina Coan5Christian Beaulieu6Fernando Cendes7Donald William Gross8Laboratory of Neuroimaging, Department of Neurology University of Campinas Campinas BrazilLaboratory of Neuroimaging, Department of Neurology University of Campinas Campinas BrazilLaboratory of Neuroimaging, Department of Neurology University of Campinas Campinas BrazilDepartment of Biomedical Engineering University of Alberta Edmonton Alberta CanadaLaboratory of Neuroimaging, Department of Neurology University of Campinas Campinas BrazilLaboratory of Neuroimaging, Department of Neurology University of Campinas Campinas BrazilDepartment of Biomedical Engineering University of Alberta Edmonton Alberta CanadaLaboratory of Neuroimaging, Department of Neurology University of Campinas Campinas BrazilDivision of Neurology, Department of Medicine University of Alberta Edmonton Alberta CanadaAbstract Objective Typical aging is associated with gradual cognitive decline and changes in brain structure. The observation that cognitive performance in mesial temporal lobe epilepsy (TLE) patients diverges from controls early in life with subsequent decline running in parallel would suggest an initial insult but does not support accelerated decline secondary to seizures. Whether TLE patients demonstrate similar trajectories of age‐related gray (GM) and white matter (WM) changes as compared to healthy controls remains uncertain. Methods 3D T1‐weighted and diffusion tensor images were acquired at a single site in 170 TLE patients (aged 23–74 years) with MRI signs of unilateral hippocampal sclerosis (HS, 77 right) and 111 healthy controls (aged 26–80 years). Global brain (GM, WM, total brain, and cerebrospinal fluid) and regional volumes (ipsi‐ and contralateral hippocampi), and fractional anisotropy (FA) of 10 tracts (three portions of corpus callosum, inferior longitudinal, inferior fronto‐occipital and uncinate fasciculi, body of fornix, dorsal and parahippocampal‐cingulum, and corticospinal tract) were compared between groups as a function of age. Results There were significant reductions of global brain and hippocampi volumes (greatest ipsilateral to HS), and FA of all 10 tracts in TLE versus controls. For TLE patients, regression lines run in parallel to those from controls for brain volumes and FA (for all tracts except the parahippocampal‐cingulum and corticospinal tract) versus age across the adult lifespan. Interpretation These results imply a developmental hindrance occurring earlier in life (likely in childhood/neurodevelopmental stages) rather than accelerated atrophy/degeneration of most brain structures herein analyzed in patients with TLE.https://doi.org/10.1002/acn3.51793 |
| spellingShingle | Clarissa Lin Yasuda Luciana Ramalho Pimentel‐Silva Guilherme Coco Beltramini Min Liu Brunno Machado de Campos Ana Carolina Coan Christian Beaulieu Fernando Cendes Donald William Gross Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy Annals of Clinical and Translational Neurology |
| title | Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy |
| title_full | Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy |
| title_fullStr | Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy |
| title_full_unstemmed | Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy |
| title_short | Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy |
| title_sort | brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy |
| url | https://doi.org/10.1002/acn3.51793 |
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