Cyclophosphamide induced physiological and biochemical changes in mice with an emphasis on sensitivity analysis
The widespread use of cyclophosphamide (CP) in medical treatment had caused ubiquitous contamination in the environment. To data, many studies have been carried out on the toxic effect of CP. However, among these toxic effects of CP, which are the most sensitive remains unclear. Present study aimed...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651320317255 |
| _version_ | 1818925338037583872 |
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| author | Zhiying Zhang Ting Pan Chunrong Liu Xiaoyun Shan Zeqiong Xu Huachang Hong Hongjun Lin Jianrong Chen Hongjie Sun |
| author_facet | Zhiying Zhang Ting Pan Chunrong Liu Xiaoyun Shan Zeqiong Xu Huachang Hong Hongjun Lin Jianrong Chen Hongjie Sun |
| author_sort | Zhiying Zhang |
| collection | DOAJ |
| description | The widespread use of cyclophosphamide (CP) in medical treatment had caused ubiquitous contamination in the environment. To data, many studies have been carried out on the toxic effect of CP. However, among these toxic effects of CP, which are the most sensitive remains unclear. Present study aimed to investigate the toxicity of CP on mice and evaluate the sensitivity of physiological-biochemical parameters upon exposure of mice to CP. Results showed that as compared with the control group, CP caused significant reduction in body weight (p < 0.01), spleen coefficient (p < 0.01), leukocyte density (p < 0.01) and alanine transaminase (ALT) in kidney (p < 0.01); However superoxide dismutase (SOD), malondialdehyde (MDA), ALT in liver and creatinine (Cr) in kidney significantly (p < 0.05) increased. Among the suppressed physiological and biochemical parameters, the sensitivity to CP toxicity was generally ranked as body weight > leukocyte density > ALT in kidney > spleen coefficient; while among the stimulated parameters, the sensitivity was ranked as MDA (liver) > Cr (kidney) > ALT (liver). Overall, the most sensitive parameters to CP toxicity may be associated with growth, immune system and the normal function of liver and kidney. |
| first_indexed | 2024-12-20T02:39:38Z |
| format | Article |
| id | doaj.art-9c80c7a2052a46cc9256ee53d4c7eb9c |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-20T02:39:38Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-9c80c7a2052a46cc9256ee53d4c7eb9c2022-12-21T19:56:21ZengElsevierEcotoxicology and Environmental Safety0147-65132021-03-01211111889Cyclophosphamide induced physiological and biochemical changes in mice with an emphasis on sensitivity analysisZhiying Zhang0Ting Pan1Chunrong Liu2Xiaoyun Shan3Zeqiong Xu4Huachang Hong5Hongjun Lin6Jianrong Chen7Hongjie Sun8College of Geography and Environmental Science, Zhejiang Normal University, Jinhua, ChinaCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua, ChinaCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua, ChinaJinhua Municipal Central Hospital, Jinhua, ChinaCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua, ChinaCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua, China; Corresponding authors.College of Geography and Environmental Science, Zhejiang Normal University, Jinhua, ChinaCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua, China; Jinhua Municipal Central Hospital, Jinhua, ChinaCollege of Geography and Environmental Science, Zhejiang Normal University, Jinhua, China; Corresponding authors.The widespread use of cyclophosphamide (CP) in medical treatment had caused ubiquitous contamination in the environment. To data, many studies have been carried out on the toxic effect of CP. However, among these toxic effects of CP, which are the most sensitive remains unclear. Present study aimed to investigate the toxicity of CP on mice and evaluate the sensitivity of physiological-biochemical parameters upon exposure of mice to CP. Results showed that as compared with the control group, CP caused significant reduction in body weight (p < 0.01), spleen coefficient (p < 0.01), leukocyte density (p < 0.01) and alanine transaminase (ALT) in kidney (p < 0.01); However superoxide dismutase (SOD), malondialdehyde (MDA), ALT in liver and creatinine (Cr) in kidney significantly (p < 0.05) increased. Among the suppressed physiological and biochemical parameters, the sensitivity to CP toxicity was generally ranked as body weight > leukocyte density > ALT in kidney > spleen coefficient; while among the stimulated parameters, the sensitivity was ranked as MDA (liver) > Cr (kidney) > ALT (liver). Overall, the most sensitive parameters to CP toxicity may be associated with growth, immune system and the normal function of liver and kidney.http://www.sciencedirect.com/science/article/pii/S0147651320317255CyclophosphamideToxicitySensitivityBody weightPhysiological and biochemical parameters |
| spellingShingle | Zhiying Zhang Ting Pan Chunrong Liu Xiaoyun Shan Zeqiong Xu Huachang Hong Hongjun Lin Jianrong Chen Hongjie Sun Cyclophosphamide induced physiological and biochemical changes in mice with an emphasis on sensitivity analysis Ecotoxicology and Environmental Safety Cyclophosphamide Toxicity Sensitivity Body weight Physiological and biochemical parameters |
| title | Cyclophosphamide induced physiological and biochemical changes in mice with an emphasis on sensitivity analysis |
| title_full | Cyclophosphamide induced physiological and biochemical changes in mice with an emphasis on sensitivity analysis |
| title_fullStr | Cyclophosphamide induced physiological and biochemical changes in mice with an emphasis on sensitivity analysis |
| title_full_unstemmed | Cyclophosphamide induced physiological and biochemical changes in mice with an emphasis on sensitivity analysis |
| title_short | Cyclophosphamide induced physiological and biochemical changes in mice with an emphasis on sensitivity analysis |
| title_sort | cyclophosphamide induced physiological and biochemical changes in mice with an emphasis on sensitivity analysis |
| topic | Cyclophosphamide Toxicity Sensitivity Body weight Physiological and biochemical parameters |
| url | http://www.sciencedirect.com/science/article/pii/S0147651320317255 |
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