Bile acids specifically increase hepatitis C virus RNA-replication.

Bile acids specifically increase hepatitis C virus RNA-replication.

BACKGROUND: Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends o...

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Bibliographic Details
Main Authors: Patrick Chhatwal, Dorothea Bankwitz, Juliane Gentzsch, Anne Frentzen, Philipp Schult, Volker Lohmann, Thomas Pietschmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338857?pdf=render

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