Perioperative hemoglobin area under the curve is an independent predictor of renal failure after cardiac surgery. Results from a Spanish multicenter retrospective cohort study.
Perioperative anemia is an important risk factor for cardiac surgery-associated acute kidney injury (CSA-AKI). Nonetheless, the severity of the anemia and the time in the perioperative period in which the hemoglobin level should be considered as a risk factor is conflicting. The present study introd...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5321429?pdf=render |
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| author | Paula Duque-Sosa Diego Martínez-Urbistondo Gemma Echarri Raquel Callejas María Josefa Iribarren Gregorio Rábago Pablo Monedero Spanish group of renal dysfunction in cardiac surgery (GEDRCC-2) |
| author_facet | Paula Duque-Sosa Diego Martínez-Urbistondo Gemma Echarri Raquel Callejas María Josefa Iribarren Gregorio Rábago Pablo Monedero Spanish group of renal dysfunction in cardiac surgery (GEDRCC-2) |
| author_sort | Paula Duque-Sosa |
| collection | DOAJ |
| description | Perioperative anemia is an important risk factor for cardiac surgery-associated acute kidney injury (CSA-AKI). Nonetheless, the severity of the anemia and the time in the perioperative period in which the hemoglobin level should be considered as a risk factor is conflicting. The present study introduces the concept of perioperative hemoglobin area under the curve (pHb-AUC) as a surrogate marker of the evolution of perioperative hemoglobin concentration. Through a retrospective analysis of prospectively collected data, we assessed this new variable as a risk factor for the development of acute kidney injury after cardiac surgery in 966 adult patients who underwent cardiac surgery with cardiopulmonary bypass, at twenty-three academic hospitals in Spain. Exclusion criteria were patients on renal replacement therapy, who needed a reoperation because of bleeding and/or with missing perioperative hemoglobin or creatinine values. Using a multivariate regression analysis, we found that a pHb-AUC <19 g/dL was an independent risk factor for CSA-AKI even after adjustment for intraoperative red blood cell transfusion (OR 1.41, p <0.05). It was also associated with mortality (OR 2.48, p <0.01) and prolonged hospital length of stay (4.67 ± 0.99 days, p <0.001). |
| first_indexed | 2024-12-22T07:00:26Z |
| format | Article |
| id | doaj.art-9c87c0fc496f4966b6c95d1ccc4c6485 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T07:00:26Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9c87c0fc496f4966b6c95d1ccc4c64852022-12-21T18:34:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017202110.1371/journal.pone.0172021Perioperative hemoglobin area under the curve is an independent predictor of renal failure after cardiac surgery. Results from a Spanish multicenter retrospective cohort study.Paula Duque-SosaDiego Martínez-UrbistondoGemma EcharriRaquel CallejasMaría Josefa IribarrenGregorio RábagoPablo MonederoSpanish group of renal dysfunction in cardiac surgery (GEDRCC-2)Perioperative anemia is an important risk factor for cardiac surgery-associated acute kidney injury (CSA-AKI). Nonetheless, the severity of the anemia and the time in the perioperative period in which the hemoglobin level should be considered as a risk factor is conflicting. The present study introduces the concept of perioperative hemoglobin area under the curve (pHb-AUC) as a surrogate marker of the evolution of perioperative hemoglobin concentration. Through a retrospective analysis of prospectively collected data, we assessed this new variable as a risk factor for the development of acute kidney injury after cardiac surgery in 966 adult patients who underwent cardiac surgery with cardiopulmonary bypass, at twenty-three academic hospitals in Spain. Exclusion criteria were patients on renal replacement therapy, who needed a reoperation because of bleeding and/or with missing perioperative hemoglobin or creatinine values. Using a multivariate regression analysis, we found that a pHb-AUC <19 g/dL was an independent risk factor for CSA-AKI even after adjustment for intraoperative red blood cell transfusion (OR 1.41, p <0.05). It was also associated with mortality (OR 2.48, p <0.01) and prolonged hospital length of stay (4.67 ± 0.99 days, p <0.001).http://europepmc.org/articles/PMC5321429?pdf=render |
| spellingShingle | Paula Duque-Sosa Diego Martínez-Urbistondo Gemma Echarri Raquel Callejas María Josefa Iribarren Gregorio Rábago Pablo Monedero Spanish group of renal dysfunction in cardiac surgery (GEDRCC-2) Perioperative hemoglobin area under the curve is an independent predictor of renal failure after cardiac surgery. Results from a Spanish multicenter retrospective cohort study. PLoS ONE |
| title | Perioperative hemoglobin area under the curve is an independent predictor of renal failure after cardiac surgery. Results from a Spanish multicenter retrospective cohort study. |
| title_full | Perioperative hemoglobin area under the curve is an independent predictor of renal failure after cardiac surgery. Results from a Spanish multicenter retrospective cohort study. |
| title_fullStr | Perioperative hemoglobin area under the curve is an independent predictor of renal failure after cardiac surgery. Results from a Spanish multicenter retrospective cohort study. |
| title_full_unstemmed | Perioperative hemoglobin area under the curve is an independent predictor of renal failure after cardiac surgery. Results from a Spanish multicenter retrospective cohort study. |
| title_short | Perioperative hemoglobin area under the curve is an independent predictor of renal failure after cardiac surgery. Results from a Spanish multicenter retrospective cohort study. |
| title_sort | perioperative hemoglobin area under the curve is an independent predictor of renal failure after cardiac surgery results from a spanish multicenter retrospective cohort study |
| url | http://europepmc.org/articles/PMC5321429?pdf=render |
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