Creatine or guanidinoacetic acid? Which is more effective at enhancing growth, tissue creatine stores, quality of meat, and genes controlling growth/myogenesis in Mulard ducks
This study aimed to determine the effectiveness of guanidinoacetic acid (GAA) with or without methionine (Met) compared to creatine (CREA) at enhancing duck’s performance, restoring tissue CREA and improving meat quality. Mulard ducklings (n = 250) were randomly assigned to control (without additive...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Journal of Applied Animal Research |
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| Online Access: | http://dx.doi.org/10.1080/09712119.2019.1590205 |
| _version_ | 1830083111267860480 |
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| author | Doaa Ibrahim Rania El Sayed Ahmed Abdelfattah-Hassan A. M. Morshedy |
| author_facet | Doaa Ibrahim Rania El Sayed Ahmed Abdelfattah-Hassan A. M. Morshedy |
| author_sort | Doaa Ibrahim |
| collection | DOAJ |
| description | This study aimed to determine the effectiveness of guanidinoacetic acid (GAA) with or without methionine (Met) compared to creatine (CREA) at enhancing duck’s performance, restoring tissue CREA and improving meat quality. Mulard ducklings (n = 250) were randomly assigned to control (without additives), or control plus CREA, GAA, GAA + 0.2%Met (GAAMet0.2) or GAA + 0.4%Met (GAAMet0.4) groups in a completely random experimental design. Dietary supplementation of CREA or GAA significantly increased (P < 0.05) overall weight gain and improved feed:gain ratio. Supplementation of GAA (especially GAAMet0.4 group) significantly increased (P < 0.05) carcass and breast yield. Meat pH values were higher (P < 0.05) with dietary GAA + Met or CREA. Providing of dietary GAA + Met led to higher levels of plasma CREA than dietary CREA itself. The molecular investigation indicated that dietary CREA or GAA with Met enhanced the gene expression of hepatic insulin-like growth factor-1, growth hormone and muscle myogenin. Finally, dietary GAA + Met was superior to CREA in improving duck’s performance based on molecular markers related to growth (IGF-1 and growth hormone) and myogenesis (upregulating myogenin and downregulating myostatin). Although, dietary GAA + Met enhanced muscle’s CREA loading than CREA, the long-term GAA supplementation in ducks may induce methyl-groups shortage for protein synthesis, this was resolved with Met addition in our study. |
| first_indexed | 2024-12-14T16:14:44Z |
| format | Article |
| id | doaj.art-9c87d2a7000f4520afc224b506d3dc4c |
| institution | Directory Open Access Journal |
| issn | 0971-2119 0974-1844 |
| language | English |
| last_indexed | 2024-12-14T16:14:44Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Applied Animal Research |
| spelling | doaj.art-9c87d2a7000f4520afc224b506d3dc4c2022-12-21T22:54:55ZengTaylor & Francis GroupJournal of Applied Animal Research0971-21190974-18442019-01-0147115916610.1080/09712119.2019.15902051590205Creatine or guanidinoacetic acid? Which is more effective at enhancing growth, tissue creatine stores, quality of meat, and genes controlling growth/myogenesis in Mulard ducksDoaa Ibrahim0Rania El Sayed1Ahmed Abdelfattah-Hassan2A. M. Morshedy3Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Zagazig UniversityDepartment of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Zagazig UniversityDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Zagazig UniversityDepartment of Food Control, Faculty of Veterinary Medicine, Zagazig UniversityThis study aimed to determine the effectiveness of guanidinoacetic acid (GAA) with or without methionine (Met) compared to creatine (CREA) at enhancing duck’s performance, restoring tissue CREA and improving meat quality. Mulard ducklings (n = 250) were randomly assigned to control (without additives), or control plus CREA, GAA, GAA + 0.2%Met (GAAMet0.2) or GAA + 0.4%Met (GAAMet0.4) groups in a completely random experimental design. Dietary supplementation of CREA or GAA significantly increased (P < 0.05) overall weight gain and improved feed:gain ratio. Supplementation of GAA (especially GAAMet0.4 group) significantly increased (P < 0.05) carcass and breast yield. Meat pH values were higher (P < 0.05) with dietary GAA + Met or CREA. Providing of dietary GAA + Met led to higher levels of plasma CREA than dietary CREA itself. The molecular investigation indicated that dietary CREA or GAA with Met enhanced the gene expression of hepatic insulin-like growth factor-1, growth hormone and muscle myogenin. Finally, dietary GAA + Met was superior to CREA in improving duck’s performance based on molecular markers related to growth (IGF-1 and growth hormone) and myogenesis (upregulating myogenin and downregulating myostatin). Although, dietary GAA + Met enhanced muscle’s CREA loading than CREA, the long-term GAA supplementation in ducks may induce methyl-groups shortage for protein synthesis, this was resolved with Met addition in our study.http://dx.doi.org/10.1080/09712119.2019.1590205creagaamethionineguanidinoacetic acid metabolismigfmyogenin |
| spellingShingle | Doaa Ibrahim Rania El Sayed Ahmed Abdelfattah-Hassan A. M. Morshedy Creatine or guanidinoacetic acid? Which is more effective at enhancing growth, tissue creatine stores, quality of meat, and genes controlling growth/myogenesis in Mulard ducks Journal of Applied Animal Research crea gaa methionine guanidinoacetic acid metabolism igf myogenin |
| title | Creatine or guanidinoacetic acid? Which is more effective at enhancing growth, tissue creatine stores, quality of meat, and genes controlling growth/myogenesis in Mulard ducks |
| title_full | Creatine or guanidinoacetic acid? Which is more effective at enhancing growth, tissue creatine stores, quality of meat, and genes controlling growth/myogenesis in Mulard ducks |
| title_fullStr | Creatine or guanidinoacetic acid? Which is more effective at enhancing growth, tissue creatine stores, quality of meat, and genes controlling growth/myogenesis in Mulard ducks |
| title_full_unstemmed | Creatine or guanidinoacetic acid? Which is more effective at enhancing growth, tissue creatine stores, quality of meat, and genes controlling growth/myogenesis in Mulard ducks |
| title_short | Creatine or guanidinoacetic acid? Which is more effective at enhancing growth, tissue creatine stores, quality of meat, and genes controlling growth/myogenesis in Mulard ducks |
| title_sort | creatine or guanidinoacetic acid which is more effective at enhancing growth tissue creatine stores quality of meat and genes controlling growth myogenesis in mulard ducks |
| topic | crea gaa methionine guanidinoacetic acid metabolism igf myogenin |
| url | http://dx.doi.org/10.1080/09712119.2019.1590205 |
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