New Insights into the Role of miR-29a in Hepatocellular Carcinoma: Implications in Mechanisms and Theragnostics
Hepatocellular carcinoma (HCC) remains one of the most lethal human cancer globally. For advanced HCC, curable plan for advanced HCC is yet to be established, and the prognosis remains poor. The detail mechanisms underlying the progression of HCC tumorigenicity and the corruption of tumor microenvir...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/3/219 |
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| author | Ya-Ling Yang Yen-Hsiang Chang Chia-Jung Li Ying-Hsien Huang Ming-Chao Tsai Pei-Yi Chu Hung-Yu Lin |
| author_facet | Ya-Ling Yang Yen-Hsiang Chang Chia-Jung Li Ying-Hsien Huang Ming-Chao Tsai Pei-Yi Chu Hung-Yu Lin |
| author_sort | Ya-Ling Yang |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) remains one of the most lethal human cancer globally. For advanced HCC, curable plan for advanced HCC is yet to be established, and the prognosis remains poor. The detail mechanisms underlying the progression of HCC tumorigenicity and the corruption of tumor microenvironment (TME) is complex and inconclusive. A growing body of studies demonstrate microRNAs (miRs) are important regulators in the tumorigenicity and TME development. Notably, mounting evidences indicate miR-29a play a crucial role in exerting hepatoprotective effect on various types of stress and involved in the progression of HCC, which elucidates their potential theragnostic implications. In this review, we reviewed the advanced insights into the detail mechanisms by which miR-29a dictates carcinogenesis, epigenetic program, and metabolic adaptation, and implicated in the sponging activity of competitive endogenous RNAs (ceRNA) and the TME components in the scenario of HCC. Furthermore, we highlighted its clinical significance in diagnosis and prognosis, as well as the emerging therapeutics centered on the activation of miR-29a. |
| first_indexed | 2024-03-10T13:06:59Z |
| format | Article |
| id | doaj.art-9c888ecbce5848b6805b6029c21f5a99 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T13:06:59Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-9c888ecbce5848b6805b6029c21f5a992023-11-21T11:03:44ZengMDPI AGJournal of Personalized Medicine2075-44262021-03-0111321910.3390/jpm11030219New Insights into the Role of miR-29a in Hepatocellular Carcinoma: Implications in Mechanisms and TheragnosticsYa-Ling Yang0Yen-Hsiang Chang1Chia-Jung Li2Ying-Hsien Huang3Ming-Chao Tsai4Pei-Yi Chu5Hung-Yu Lin6Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pathology, Show Chwan Memorial Hospital, Changhua 500, TaiwanResearch Assistant Center, Show Chwan Memorial Hospital, Changhua 500, TaiwanHepatocellular carcinoma (HCC) remains one of the most lethal human cancer globally. For advanced HCC, curable plan for advanced HCC is yet to be established, and the prognosis remains poor. The detail mechanisms underlying the progression of HCC tumorigenicity and the corruption of tumor microenvironment (TME) is complex and inconclusive. A growing body of studies demonstrate microRNAs (miRs) are important regulators in the tumorigenicity and TME development. Notably, mounting evidences indicate miR-29a play a crucial role in exerting hepatoprotective effect on various types of stress and involved in the progression of HCC, which elucidates their potential theragnostic implications. In this review, we reviewed the advanced insights into the detail mechanisms by which miR-29a dictates carcinogenesis, epigenetic program, and metabolic adaptation, and implicated in the sponging activity of competitive endogenous RNAs (ceRNA) and the TME components in the scenario of HCC. Furthermore, we highlighted its clinical significance in diagnosis and prognosis, as well as the emerging therapeutics centered on the activation of miR-29a.https://www.mdpi.com/2075-4426/11/3/219hepatocellular carcinomamiR-29adiagnosistherapeuticscarcinogenesisepigenetics |
| spellingShingle | Ya-Ling Yang Yen-Hsiang Chang Chia-Jung Li Ying-Hsien Huang Ming-Chao Tsai Pei-Yi Chu Hung-Yu Lin New Insights into the Role of miR-29a in Hepatocellular Carcinoma: Implications in Mechanisms and Theragnostics Journal of Personalized Medicine hepatocellular carcinoma miR-29a diagnosis therapeutics carcinogenesis epigenetics |
| title | New Insights into the Role of miR-29a in Hepatocellular Carcinoma: Implications in Mechanisms and Theragnostics |
| title_full | New Insights into the Role of miR-29a in Hepatocellular Carcinoma: Implications in Mechanisms and Theragnostics |
| title_fullStr | New Insights into the Role of miR-29a in Hepatocellular Carcinoma: Implications in Mechanisms and Theragnostics |
| title_full_unstemmed | New Insights into the Role of miR-29a in Hepatocellular Carcinoma: Implications in Mechanisms and Theragnostics |
| title_short | New Insights into the Role of miR-29a in Hepatocellular Carcinoma: Implications in Mechanisms and Theragnostics |
| title_sort | new insights into the role of mir 29a in hepatocellular carcinoma implications in mechanisms and theragnostics |
| topic | hepatocellular carcinoma miR-29a diagnosis therapeutics carcinogenesis epigenetics |
| url | https://www.mdpi.com/2075-4426/11/3/219 |
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