Evaluation of puncture resistance force of microneedle by nonlinear FEM analysis and experimental validation
In recent years, a minimally invasive medical needle is required. The development of such a fine needle requires evaluation of puncture resistance force. We have developed various microneedles and conducted the puncture experiments to evaluate their resistance force against an artificial skin made o...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Japan Society of Mechanical Engineers
2019-09-01
|
| Series: | Journal of Biomechanical Science and Engineering |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jbse/14/4/14_19-00238/_pdf/-char/en |
| _version_ | 1811296763184676864 |
|---|---|
| author | Shunki YAMAMOTO Tomokazu TAKAHASHI Masato SUZUKI Seiji AOYAGI Toshio NAGASHIMA Atsushi KUNUGI Makoto CHIYONOBU Takeshi KUROIWA |
| author_facet | Shunki YAMAMOTO Tomokazu TAKAHASHI Masato SUZUKI Seiji AOYAGI Toshio NAGASHIMA Atsushi KUNUGI Makoto CHIYONOBU Takeshi KUROIWA |
| author_sort | Shunki YAMAMOTO |
| collection | DOAJ |
| description | In recent years, a minimally invasive medical needle is required. The development of such a fine needle requires evaluation of puncture resistance force. We have developed various microneedles and conducted the puncture experiments to evaluate their resistance force against an artificial skin made of silicone rubber. In this study, it is attempted to reproduce the puncture experiment by FEM simulation, in which accurate three dimensional (3D) models of needle and skin are constructed, and the conditions of material properties, model size, puncture distance, puncture speed, etc. are set to the same ones as the experiments. As a commercially available nonlinear FEM software, LS-DYNA was employed. The results of FEM analysis and those of experiment were compared to estimate what extent they are matched. As a result, the tendency of the load curve, i.e., transition of resistance force with respect to puncturing distance, and the state of skin deformation were well matched, showing the possibility of FEM analysis to reproduce the experiment. The error of resistance force between analysis and experiment was 20% at most. It is expected that the parameter study would be possible, in which the performance of needle is evaluated by changing the parameters, e.g., its size, shape, how to insert it to the skin, etc. |
| first_indexed | 2024-04-13T05:54:18Z |
| format | Article |
| id | doaj.art-9c8a5a68acf04f228275c09ea0e02dff |
| institution | Directory Open Access Journal |
| issn | 1880-9863 |
| language | English |
| last_indexed | 2024-04-13T05:54:18Z |
| publishDate | 2019-09-01 |
| publisher | The Japan Society of Mechanical Engineers |
| record_format | Article |
| series | Journal of Biomechanical Science and Engineering |
| spelling | doaj.art-9c8a5a68acf04f228275c09ea0e02dff2022-12-22T02:59:41ZengThe Japan Society of Mechanical EngineersJournal of Biomechanical Science and Engineering1880-98632019-09-0114419-0023819-0023810.1299/jbse.19-00238jbseEvaluation of puncture resistance force of microneedle by nonlinear FEM analysis and experimental validationShunki YAMAMOTO0Tomokazu TAKAHASHI1Masato SUZUKI2Seiji AOYAGI3Toshio NAGASHIMA4Atsushi KUNUGI5Makoto CHIYONOBU6Takeshi KUROIWA7Department of Mechanical Engineering, Kansai UniversityDepartment of Mechanical Engineering, Kansai UniversityDepartment of Mechanical Engineering, Kansai UniversityDepartment of Mechanical Engineering, Kansai UniversityDepartment of Engineering and Applied Sciences, Sophia UniversityJSOL CorporationJSOL CorporationJSOL CorporationIn recent years, a minimally invasive medical needle is required. The development of such a fine needle requires evaluation of puncture resistance force. We have developed various microneedles and conducted the puncture experiments to evaluate their resistance force against an artificial skin made of silicone rubber. In this study, it is attempted to reproduce the puncture experiment by FEM simulation, in which accurate three dimensional (3D) models of needle and skin are constructed, and the conditions of material properties, model size, puncture distance, puncture speed, etc. are set to the same ones as the experiments. As a commercially available nonlinear FEM software, LS-DYNA was employed. The results of FEM analysis and those of experiment were compared to estimate what extent they are matched. As a result, the tendency of the load curve, i.e., transition of resistance force with respect to puncturing distance, and the state of skin deformation were well matched, showing the possibility of FEM analysis to reproduce the experiment. The error of resistance force between analysis and experiment was 20% at most. It is expected that the parameter study would be possible, in which the performance of needle is evaluated by changing the parameters, e.g., its size, shape, how to insert it to the skin, etc.https://www.jstage.jst.go.jp/article/jbse/14/4/14_19-00238/_pdf/-char/enmicroneedlefinite element method analysispuncture resistance forceskin deformationarbitrary lagrangian and eulerian method |
| spellingShingle | Shunki YAMAMOTO Tomokazu TAKAHASHI Masato SUZUKI Seiji AOYAGI Toshio NAGASHIMA Atsushi KUNUGI Makoto CHIYONOBU Takeshi KUROIWA Evaluation of puncture resistance force of microneedle by nonlinear FEM analysis and experimental validation Journal of Biomechanical Science and Engineering microneedle finite element method analysis puncture resistance force skin deformation arbitrary lagrangian and eulerian method |
| title | Evaluation of puncture resistance force of microneedle by nonlinear FEM analysis and experimental validation |
| title_full | Evaluation of puncture resistance force of microneedle by nonlinear FEM analysis and experimental validation |
| title_fullStr | Evaluation of puncture resistance force of microneedle by nonlinear FEM analysis and experimental validation |
| title_full_unstemmed | Evaluation of puncture resistance force of microneedle by nonlinear FEM analysis and experimental validation |
| title_short | Evaluation of puncture resistance force of microneedle by nonlinear FEM analysis and experimental validation |
| title_sort | evaluation of puncture resistance force of microneedle by nonlinear fem analysis and experimental validation |
| topic | microneedle finite element method analysis puncture resistance force skin deformation arbitrary lagrangian and eulerian method |
| url | https://www.jstage.jst.go.jp/article/jbse/14/4/14_19-00238/_pdf/-char/en |
| work_keys_str_mv | AT shunkiyamamoto evaluationofpunctureresistanceforceofmicroneedlebynonlinearfemanalysisandexperimentalvalidation AT tomokazutakahashi evaluationofpunctureresistanceforceofmicroneedlebynonlinearfemanalysisandexperimentalvalidation AT masatosuzuki evaluationofpunctureresistanceforceofmicroneedlebynonlinearfemanalysisandexperimentalvalidation AT seijiaoyagi evaluationofpunctureresistanceforceofmicroneedlebynonlinearfemanalysisandexperimentalvalidation AT toshionagashima evaluationofpunctureresistanceforceofmicroneedlebynonlinearfemanalysisandexperimentalvalidation AT atsushikunugi evaluationofpunctureresistanceforceofmicroneedlebynonlinearfemanalysisandexperimentalvalidation AT makotochiyonobu evaluationofpunctureresistanceforceofmicroneedlebynonlinearfemanalysisandexperimentalvalidation AT takeshikuroiwa evaluationofpunctureresistanceforceofmicroneedlebynonlinearfemanalysisandexperimentalvalidation |