Validity of Addenbrooke's Cognitive Examination to Discriminate between Incipient Dementia and Depression in Elderly Patients of a Private Clinic in Lima, Peru
Background/Aims: Dementia and depression are different clinical conditions, but share common features, and can be indistinguishable in the initial disease stages. We aimed to establish whether the Peruvian version of the Addenbrooke's Cognitive Examination (ACE-Peru) can distinguish between the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2013-09-01
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| Series: | Dementia and Geriatric Cognitive Disorders Extra |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/354948 |
| _version_ | 1818777868206866432 |
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| author | Eder Herrera-Pérez Nilton Custodio David Lira Rosa Montesinos Liliana Bendezu |
| author_facet | Eder Herrera-Pérez Nilton Custodio David Lira Rosa Montesinos Liliana Bendezu |
| author_sort | Eder Herrera-Pérez |
| collection | DOAJ |
| description | Background/Aims: Dementia and depression are different clinical conditions, but share common features, and can be indistinguishable in the initial disease stages. We aimed to establish whether the Peruvian version of the Addenbrooke's Cognitive Examination (ACE-Peru) can distinguish between the cognitive profile in patients with incipient dementia and that in patients with depression. Methods: This was a cross-sectional study to assess the performance on the ACE-Peru of 193 elderly subjects (102 with dementia, 21 with depression, and 70 healthy controls). Depending on the diagnosis, there were two groups of cognitive impairment (CI) - the primary neurodegenerative (PN-CI) subtype and the secondary to depression (SD-CI) subtype - as well as a non-CI group. The area under the curve (AUC) of the receiver-operating characteristic curve was determined to compare the diagnostic performance, using the diagnosis of CI as the gold standard. Results: In our sample of elderly subjects aged 59-82 years with at least 7 years of education, the ACE-Peru showed a significantly better performance than the MMSE (AUC = 0.997 vs. AUC = 0.887; p Conclusions: The ACE-Peru is able to distinguish between the cognitive profile in patients with incipient dementia and that in patients with depression. |
| first_indexed | 2024-12-18T11:35:40Z |
| format | Article |
| id | doaj.art-9c8b93a1a62d41798131c9283b7fb71e |
| institution | Directory Open Access Journal |
| issn | 1664-5464 |
| language | English |
| last_indexed | 2024-12-18T11:35:40Z |
| publishDate | 2013-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Dementia and Geriatric Cognitive Disorders Extra |
| spelling | doaj.art-9c8b93a1a62d41798131c9283b7fb71e2022-12-21T21:09:31ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642013-09-013133334110.1159/000354948354948Validity of Addenbrooke's Cognitive Examination to Discriminate between Incipient Dementia and Depression in Elderly Patients of a Private Clinic in Lima, PeruEder Herrera-PérezNilton CustodioDavid LiraRosa MontesinosLiliana BendezuBackground/Aims: Dementia and depression are different clinical conditions, but share common features, and can be indistinguishable in the initial disease stages. We aimed to establish whether the Peruvian version of the Addenbrooke's Cognitive Examination (ACE-Peru) can distinguish between the cognitive profile in patients with incipient dementia and that in patients with depression. Methods: This was a cross-sectional study to assess the performance on the ACE-Peru of 193 elderly subjects (102 with dementia, 21 with depression, and 70 healthy controls). Depending on the diagnosis, there were two groups of cognitive impairment (CI) - the primary neurodegenerative (PN-CI) subtype and the secondary to depression (SD-CI) subtype - as well as a non-CI group. The area under the curve (AUC) of the receiver-operating characteristic curve was determined to compare the diagnostic performance, using the diagnosis of CI as the gold standard. Results: In our sample of elderly subjects aged 59-82 years with at least 7 years of education, the ACE-Peru showed a significantly better performance than the MMSE (AUC = 0.997 vs. AUC = 0.887; p Conclusions: The ACE-Peru is able to distinguish between the cognitive profile in patients with incipient dementia and that in patients with depression.http://www.karger.com/Article/FullText/354948DementiaDepressionDifferential diagnosisAddenbrooke’s Cognitive Examination |
| spellingShingle | Eder Herrera-Pérez Nilton Custodio David Lira Rosa Montesinos Liliana Bendezu Validity of Addenbrooke's Cognitive Examination to Discriminate between Incipient Dementia and Depression in Elderly Patients of a Private Clinic in Lima, Peru Dementia and Geriatric Cognitive Disorders Extra Dementia Depression Differential diagnosis Addenbrooke’s Cognitive Examination |
| title | Validity of Addenbrooke's Cognitive Examination to Discriminate between Incipient Dementia and Depression in Elderly Patients of a Private Clinic in Lima, Peru |
| title_full | Validity of Addenbrooke's Cognitive Examination to Discriminate between Incipient Dementia and Depression in Elderly Patients of a Private Clinic in Lima, Peru |
| title_fullStr | Validity of Addenbrooke's Cognitive Examination to Discriminate between Incipient Dementia and Depression in Elderly Patients of a Private Clinic in Lima, Peru |
| title_full_unstemmed | Validity of Addenbrooke's Cognitive Examination to Discriminate between Incipient Dementia and Depression in Elderly Patients of a Private Clinic in Lima, Peru |
| title_short | Validity of Addenbrooke's Cognitive Examination to Discriminate between Incipient Dementia and Depression in Elderly Patients of a Private Clinic in Lima, Peru |
| title_sort | validity of addenbrooke s cognitive examination to discriminate between incipient dementia and depression in elderly patients of a private clinic in lima peru |
| topic | Dementia Depression Differential diagnosis Addenbrooke’s Cognitive Examination |
| url | http://www.karger.com/Article/FullText/354948 |
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