Interplay between RNA viruses and cGAS/STING axis in innate immunity
While the function of cGAS/STING signalling axis in the innate immune response to DNA viruses is well deciphered, increasing evidence demonstrates its significant contribution in the control of RNA virus infections. After the first evidence of cGAS/STING antagonism by flaviviruses, STING activation...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1172739/full |
| _version_ | 1797853932695846912 |
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| author | Lucia Amurri Branka Horvat Mathieu Iampietro |
| author_facet | Lucia Amurri Branka Horvat Mathieu Iampietro |
| author_sort | Lucia Amurri |
| collection | DOAJ |
| description | While the function of cGAS/STING signalling axis in the innate immune response to DNA viruses is well deciphered, increasing evidence demonstrates its significant contribution in the control of RNA virus infections. After the first evidence of cGAS/STING antagonism by flaviviruses, STING activation has been detected following infection by various enveloped RNA viruses. It has been discovered that numerous viral families have implemented advanced strategies to antagonize STING pathway through their evolutionary path. This review summarizes the characterized cGAS/STING escape strategies to date, together with the proposed mechanisms of STING signalling activation perpetrated by RNA viruses and discusses possible therapeutic approaches. Further studies regarding the interaction between RNA viruses and cGAS/STING-mediated immunity could lead to major discoveries important for the understanding of immunopathogenesis and for the treatment of RNA viral infections. |
| first_indexed | 2024-04-09T19:58:48Z |
| format | Article |
| id | doaj.art-9c8c1cbee9794c02ab2c23bfbc1263a8 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-09T19:58:48Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-9c8c1cbee9794c02ab2c23bfbc1263a82023-04-03T05:21:27ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-04-011310.3389/fcimb.2023.11727391172739Interplay between RNA viruses and cGAS/STING axis in innate immunityLucia AmurriBranka HorvatMathieu IampietroWhile the function of cGAS/STING signalling axis in the innate immune response to DNA viruses is well deciphered, increasing evidence demonstrates its significant contribution in the control of RNA virus infections. After the first evidence of cGAS/STING antagonism by flaviviruses, STING activation has been detected following infection by various enveloped RNA viruses. It has been discovered that numerous viral families have implemented advanced strategies to antagonize STING pathway through their evolutionary path. This review summarizes the characterized cGAS/STING escape strategies to date, together with the proposed mechanisms of STING signalling activation perpetrated by RNA viruses and discusses possible therapeutic approaches. Further studies regarding the interaction between RNA viruses and cGAS/STING-mediated immunity could lead to major discoveries important for the understanding of immunopathogenesis and for the treatment of RNA viral infections.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1172739/fullcGAS/STINGRNA virusinnate immunityviral evasionhost-pathogen interactionsantiviral strategies |
| spellingShingle | Lucia Amurri Branka Horvat Mathieu Iampietro Interplay between RNA viruses and cGAS/STING axis in innate immunity Frontiers in Cellular and Infection Microbiology cGAS/STING RNA virus innate immunity viral evasion host-pathogen interactions antiviral strategies |
| title | Interplay between RNA viruses and cGAS/STING axis in innate immunity |
| title_full | Interplay between RNA viruses and cGAS/STING axis in innate immunity |
| title_fullStr | Interplay between RNA viruses and cGAS/STING axis in innate immunity |
| title_full_unstemmed | Interplay between RNA viruses and cGAS/STING axis in innate immunity |
| title_short | Interplay between RNA viruses and cGAS/STING axis in innate immunity |
| title_sort | interplay between rna viruses and cgas sting axis in innate immunity |
| topic | cGAS/STING RNA virus innate immunity viral evasion host-pathogen interactions antiviral strategies |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1172739/full |
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