The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study
Background. Serine and glycine play an important role in the folate-dependent one-carbon metabolism. The metabolism of serine and glycine has been shown to be associated with cancer cell proliferation. No prior epidemiologic study has investigated the associations for serum levels of serine and glyc...
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MDPI AG
2022-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/9/2199 |
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| author | Hung N. Luu Pedram Paragomi Renwei Wang Joyce Y. Huang Jennifer Adams-Haduch Øivind Midttun Arve Ulvik Tin C. Nguyen Randall E. Brand Yutang Gao Per Magne Ueland Jian-Min Yuan |
| author_facet | Hung N. Luu Pedram Paragomi Renwei Wang Joyce Y. Huang Jennifer Adams-Haduch Øivind Midttun Arve Ulvik Tin C. Nguyen Randall E. Brand Yutang Gao Per Magne Ueland Jian-Min Yuan |
| author_sort | Hung N. Luu |
| collection | DOAJ |
| description | Background. Serine and glycine play an important role in the folate-dependent one-carbon metabolism. The metabolism of serine and glycine has been shown to be associated with cancer cell proliferation. No prior epidemiologic study has investigated the associations for serum levels of serine and glycine with pancreatic cancer risk. Methods. We conducted a nested case-control study involved 129 incident pancreatic cancer cases and 258 individually matched controls within a prospective cohort study of 18,244 male residents in Shanghai, China. Glycine and serine and related metabolites in pre-diagnostic serum were quantified using gas chromatography-tandem mass spectrometry. A conditional logistic regression method was used to evaluate the associations for serine, glycine, and related metabolites with pancreatic cancer risk with adjustment for potential confounders. Results: Odds ratios (95% confidence intervals) of pancreatic cancer for the highest quartile of serine and glycine were 0.33 (0.14–0.75) and 0.25 (0.11–0.58), respectively, compared with their respective lowest quartiles (both <i>p</i>’s < 0.01). No significant association with risk of pancreatic cancer was observed for other serine- or glycine related metabolites including cystathionine, cysteine, and sarcosine. Conclusion. The risk of pancreatic cancer was reduced by more than 70% in individuals with elevated levels of glycine and serine in serum collected, on average, more than 10 years prior to cancer diagnosis in a prospectively designed case-control study. These novel findings support a protective role of serine and glycine against the development of pancreatic cancer in humans that might have an implication for cancer prevention. |
| first_indexed | 2024-03-10T04:18:10Z |
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| id | doaj.art-9c8c357b63264a09bd4edb32bc13cf16 |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:18:10Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9c8c357b63264a09bd4edb32bc13cf162023-11-23T07:56:16ZengMDPI AGCancers2072-66942022-04-01149219910.3390/cancers14092199The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort StudyHung N. Luu0Pedram Paragomi1Renwei Wang2Joyce Y. Huang3Jennifer Adams-Haduch4Øivind Midttun5Arve Ulvik6Tin C. Nguyen7Randall E. Brand8Yutang Gao9Per Magne Ueland10Jian-Min Yuan11UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, 5150 Centre Avenue, Suite 4C, Pittsburgh, PA 15232, USAUPMC Hillman Cancer Center, University of Pittsburgh Medical Center, 5150 Centre Avenue, Suite 4C, Pittsburgh, PA 15232, USAUPMC Hillman Cancer Center, University of Pittsburgh Medical Center, 5150 Centre Avenue, Suite 4C, Pittsburgh, PA 15232, USAUPMC Hillman Cancer Center, University of Pittsburgh Medical Center, 5150 Centre Avenue, Suite 4C, Pittsburgh, PA 15232, USAUPMC Hillman Cancer Center, University of Pittsburgh Medical Center, 5150 Centre Avenue, Suite 4C, Pittsburgh, PA 15232, USABevital A/S, Jonas Lies Veg 87, 5021 Bergen, NorwayDepartment of Clinical Science, University of Bergen, Postboks 7804, 5020 Bergen, NorwayDepartment of Computer Science and Engineering, University of Nevada at Reno, Reno, NV 89557, USAUPMC Hillman Cancer Center, University of Pittsburgh Medical Center, 5150 Centre Avenue, Suite 4C, Pittsburgh, PA 15232, USADepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201112, ChinaBevital A/S, Jonas Lies Veg 87, 5021 Bergen, NorwayUPMC Hillman Cancer Center, University of Pittsburgh Medical Center, 5150 Centre Avenue, Suite 4C, Pittsburgh, PA 15232, USABackground. Serine and glycine play an important role in the folate-dependent one-carbon metabolism. The metabolism of serine and glycine has been shown to be associated with cancer cell proliferation. No prior epidemiologic study has investigated the associations for serum levels of serine and glycine with pancreatic cancer risk. Methods. We conducted a nested case-control study involved 129 incident pancreatic cancer cases and 258 individually matched controls within a prospective cohort study of 18,244 male residents in Shanghai, China. Glycine and serine and related metabolites in pre-diagnostic serum were quantified using gas chromatography-tandem mass spectrometry. A conditional logistic regression method was used to evaluate the associations for serine, glycine, and related metabolites with pancreatic cancer risk with adjustment for potential confounders. Results: Odds ratios (95% confidence intervals) of pancreatic cancer for the highest quartile of serine and glycine were 0.33 (0.14–0.75) and 0.25 (0.11–0.58), respectively, compared with their respective lowest quartiles (both <i>p</i>’s < 0.01). No significant association with risk of pancreatic cancer was observed for other serine- or glycine related metabolites including cystathionine, cysteine, and sarcosine. Conclusion. The risk of pancreatic cancer was reduced by more than 70% in individuals with elevated levels of glycine and serine in serum collected, on average, more than 10 years prior to cancer diagnosis in a prospectively designed case-control study. These novel findings support a protective role of serine and glycine against the development of pancreatic cancer in humans that might have an implication for cancer prevention.https://www.mdpi.com/2072-6694/14/9/2199pancreatic cancerrisk factorsserineglycine |
| spellingShingle | Hung N. Luu Pedram Paragomi Renwei Wang Joyce Y. Huang Jennifer Adams-Haduch Øivind Midttun Arve Ulvik Tin C. Nguyen Randall E. Brand Yutang Gao Per Magne Ueland Jian-Min Yuan The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study Cancers pancreatic cancer risk factors serine glycine |
| title | The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study |
| title_full | The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study |
| title_fullStr | The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study |
| title_full_unstemmed | The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study |
| title_short | The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study |
| title_sort | association between serum serine and glycine and related metabolites with pancreatic cancer in a prospective cohort study |
| topic | pancreatic cancer risk factors serine glycine |
| url | https://www.mdpi.com/2072-6694/14/9/2199 |
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