Seroepidemiology of Toxoplasmosis in Hemodialysis Patients in Senegal
Toxoplasmosis in immunocompromised patients results in either reactivation of latent toxoplasmosis or acute infection. In the framework of the kidney transplantation program in Senegal, the serological screening of potential pre-transplant and transplanted patients can prevent the disease. This stud...
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MDPI AG
2023-04-01
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| Series: | Parasitologia |
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| Online Access: | https://www.mdpi.com/2673-6772/3/2/15 |
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| author | Mame Cheikh Seck Moustapha Mbow Sidy Mohamed Seck Yacine Ameth Dia Ibrahima Diallo Marouba Cisse Moctar Gningue Victoria Daou Baratou Coundoul Yaya Kane Mouhamadou Moustapha Cisse Adama Kama Khadim Diongue Papa Aly Thiam Gueye Cheikh Faye Mamadou Alpha Diallo Mouhamadou Ndiaye Aida Sadikh Badiane Alioune Dièye Souleymane Mboup Daouda Ndiaye |
| author_facet | Mame Cheikh Seck Moustapha Mbow Sidy Mohamed Seck Yacine Ameth Dia Ibrahima Diallo Marouba Cisse Moctar Gningue Victoria Daou Baratou Coundoul Yaya Kane Mouhamadou Moustapha Cisse Adama Kama Khadim Diongue Papa Aly Thiam Gueye Cheikh Faye Mamadou Alpha Diallo Mouhamadou Ndiaye Aida Sadikh Badiane Alioune Dièye Souleymane Mboup Daouda Ndiaye |
| author_sort | Mame Cheikh Seck |
| collection | DOAJ |
| description | Toxoplasmosis in immunocompromised patients results in either reactivation of latent toxoplasmosis or acute infection. In the framework of the kidney transplantation program in Senegal, the serological screening of potential pre-transplant and transplanted patients can prevent the disease. This study aimed to assess the seroprevalence of toxoplasmosis in a cohort of hemodialysis patients, candidates for kidney transplantation. To this end, a multicentre cross-sectional study was conducted in 2020 in six dialysis units from five regions. Blood samples and sociodemographic data were collected from each patient. IgG and IgM against <i>T. gondii</i> antibodies were assessed by a chemiluminescent method using Architect ci4100, and statistical analysis was performed using R software. Overall, 211 hemodialysis patients aged from 18 to 77 years were enrolled. The mean age was 42.62 years ± 13.6, and the sex ratio M/F was 1.24. The overall seroprevalence of <i>T. gondii</i> was 41.7%, with the highest value being recorded in the region of Kaolack (44.4%). Patients aged over 60 years were more typically infected, at a proportion of 56.0%. Regarding sex, males elicited a higher prevalence (44.4.%) than females did. Patients of an upper socioeconomic status were less affected, and contact with cats was not associated with toxoplasmosis. By education level, the illiterate group was most affected one. Overall, this first study of toxoplasmosis among Senegalese hemodialysis patients indicates high seroprevalence. |
| first_indexed | 2024-03-11T02:04:28Z |
| format | Article |
| id | doaj.art-9c8ca4222fe84dcda93d511b8bbdbfc3 |
| institution | Directory Open Access Journal |
| issn | 2673-6772 |
| language | English |
| last_indexed | 2024-03-11T02:04:28Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Parasitologia |
| spelling | doaj.art-9c8ca4222fe84dcda93d511b8bbdbfc32023-11-18T11:59:04ZengMDPI AGParasitologia2673-67722023-04-013214215010.3390/parasitologia3020015Seroepidemiology of Toxoplasmosis in Hemodialysis Patients in SenegalMame Cheikh Seck0Moustapha Mbow1Sidy Mohamed Seck2Yacine Ameth Dia3Ibrahima Diallo4Marouba Cisse5Moctar Gningue6Victoria Daou7Baratou Coundoul8Yaya Kane9Mouhamadou Moustapha Cisse10Adama Kama11Khadim Diongue12Papa Aly Thiam Gueye13Cheikh Faye14Mamadou Alpha Diallo15Mouhamadou Ndiaye16Aida Sadikh Badiane17Alioune Dièye18Souleymane Mboup19Daouda Ndiaye20Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 16477, SenegalLaboratory of Ouakam Military Hospital, Dakar 28216, SenegalDepartment of Nephrology/Internal Medicine, Faculty of Health Sciences and IRL-3189 Environnement, Santé, Sociétés, University Gaston Berger of Saint-Louis, Saint-Louis 00234, SenegalInstitute of Health Research, Epidemiological Surveillance, and Training, Dakar 7325, SenegalDepartment of Immunology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 10700, SenegalDepartment of Immunology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 10700, SenegalDepartment of Immunology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 10700, SenegalLaboratory of Ouakam Military Hospital, Dakar 28216, SenegalDialysis Center, Ouakam Military Hospital, Dakar 28216, SenegalFaculty of Health Sciences, University Assane Seck, Ziguinchor 523, SenegalFaculty of Health Sciences, University of Thies, Thies 21000, SenegalEl Hadji Ibrahima Niass Regional Hospital of Kaolack, Kaolack 5085, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 16477, SenegalLaboratory of Ouakam Military Hospital, Dakar 28216, SenegalLaboratory of Ouakam Military Hospital, Dakar 28216, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 16477, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 16477, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 16477, SenegalDepartment of Immunology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 10700, SenegalInstitute of Health Research, Epidemiological Surveillance, and Training, Dakar 7325, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 16477, SenegalToxoplasmosis in immunocompromised patients results in either reactivation of latent toxoplasmosis or acute infection. In the framework of the kidney transplantation program in Senegal, the serological screening of potential pre-transplant and transplanted patients can prevent the disease. This study aimed to assess the seroprevalence of toxoplasmosis in a cohort of hemodialysis patients, candidates for kidney transplantation. To this end, a multicentre cross-sectional study was conducted in 2020 in six dialysis units from five regions. Blood samples and sociodemographic data were collected from each patient. IgG and IgM against <i>T. gondii</i> antibodies were assessed by a chemiluminescent method using Architect ci4100, and statistical analysis was performed using R software. Overall, 211 hemodialysis patients aged from 18 to 77 years were enrolled. The mean age was 42.62 years ± 13.6, and the sex ratio M/F was 1.24. The overall seroprevalence of <i>T. gondii</i> was 41.7%, with the highest value being recorded in the region of Kaolack (44.4%). Patients aged over 60 years were more typically infected, at a proportion of 56.0%. Regarding sex, males elicited a higher prevalence (44.4.%) than females did. Patients of an upper socioeconomic status were less affected, and contact with cats was not associated with toxoplasmosis. By education level, the illiterate group was most affected one. Overall, this first study of toxoplasmosis among Senegalese hemodialysis patients indicates high seroprevalence.https://www.mdpi.com/2673-6772/3/2/15seroprevalencetoxoplasmosishemodialysis patientsSenegal |
| spellingShingle | Mame Cheikh Seck Moustapha Mbow Sidy Mohamed Seck Yacine Ameth Dia Ibrahima Diallo Marouba Cisse Moctar Gningue Victoria Daou Baratou Coundoul Yaya Kane Mouhamadou Moustapha Cisse Adama Kama Khadim Diongue Papa Aly Thiam Gueye Cheikh Faye Mamadou Alpha Diallo Mouhamadou Ndiaye Aida Sadikh Badiane Alioune Dièye Souleymane Mboup Daouda Ndiaye Seroepidemiology of Toxoplasmosis in Hemodialysis Patients in Senegal Parasitologia seroprevalence toxoplasmosis hemodialysis patients Senegal |
| title | Seroepidemiology of Toxoplasmosis in Hemodialysis Patients in Senegal |
| title_full | Seroepidemiology of Toxoplasmosis in Hemodialysis Patients in Senegal |
| title_fullStr | Seroepidemiology of Toxoplasmosis in Hemodialysis Patients in Senegal |
| title_full_unstemmed | Seroepidemiology of Toxoplasmosis in Hemodialysis Patients in Senegal |
| title_short | Seroepidemiology of Toxoplasmosis in Hemodialysis Patients in Senegal |
| title_sort | seroepidemiology of toxoplasmosis in hemodialysis patients in senegal |
| topic | seroprevalence toxoplasmosis hemodialysis patients Senegal |
| url | https://www.mdpi.com/2673-6772/3/2/15 |
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