3002 Effect of Long-Term NSAID Use on Opioid Abuse and Health Outcomes among Breast Cancer Patients
OBJECTIVES/SPECIFIC AIMS: Cancer related pain presents a significant risk for opioid abuse among cancer survivors and contributes to the current opioid crisis. Nearly 90% of breast cancer patients have been reported to have cancer-related pain requiring treatment. Opioids, in combination with NSAIDs...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2019-03-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866119000955/type/journal_article |
| _version_ | 1811156654990819328 |
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| author | Nnaemeka E Onyeakusi Semiu Gbadamosi Fahad Mukhtar Chinelo Orji Ugochukwu Ugwuowo Onyenikewe Igbeta Adeyinka Adejumo |
| author_facet | Nnaemeka E Onyeakusi Semiu Gbadamosi Fahad Mukhtar Chinelo Orji Ugochukwu Ugwuowo Onyenikewe Igbeta Adeyinka Adejumo |
| author_sort | Nnaemeka E Onyeakusi |
| collection | DOAJ |
| description | OBJECTIVES/SPECIFIC AIMS: Cancer related pain presents a significant risk for opioid abuse among cancer survivors and contributes to the current opioid crisis. Nearly 90% of breast cancer patients have been reported to have cancer-related pain requiring treatment. Opioids, in combination with NSAIDs, have been widely used for pain management in this population despite the risk of abuse. Long-term NSAID use due to their antineoplastic and neuroprotective effects may offer additional protective effects against opioid abuse. Here, we assess the relationship between NSAID use and opioid abuse among breast cancer patients. METHODS/STUDY POPULATION: Using ICD-9-CM codes, we identified and selected women aged >18 years with breast cancer from the National Inpatient Sample (NIS). Our primary predictor was a history of long-term NSAID use. Opioid abuse was the primary outcome of interest. Secondary outcomes were inpatient mortality and length of stay. Multivariable regression models were employed in assessing the association between predictors and outcomes while adjusting for relevant covariates. RESULTS/ANTICIPATED RESULTS: Among 170,644 women with breast cancer, 7,838 (4.6%) reported a history of long-term NSAID use. Patients with a history of long-term NSAID use had lower odds of opioid abuse (aOR 0.53; 95% CI [0.32-0.88]) and in-hospital mortality (aOR 0.52; 95% CI [0.45-0.60]) and were likely to have shorter hospital stay (7.12 vs. 8.11 days) compared to women with no history of long-term NSAID use. DISCUSSION/SIGNIFICANCE OF IMPACT: Long-term NSAID use may offer a protective effect against opioid abuse and improve in-hospital outcomes translating to better quality of life and healthcare utilization indices among breast cancer patients. |
| first_indexed | 2024-04-10T04:53:57Z |
| format | Article |
| id | doaj.art-9c8d8dcaba1b40d3ba110cb3791b9adf |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:53:57Z |
| publishDate | 2019-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-9c8d8dcaba1b40d3ba110cb3791b9adf2023-03-09T12:30:30ZengCambridge University PressJournal of Clinical and Translational Science2059-86612019-03-013393910.1017/cts.2019.953002 Effect of Long-Term NSAID Use on Opioid Abuse and Health Outcomes among Breast Cancer PatientsNnaemeka E Onyeakusi0Semiu Gbadamosi1Fahad Mukhtar2Chinelo Orji3Ugochukwu Ugwuowo4Onyenikewe Igbeta5Adeyinka Adejumo6BronxCare Hospital CenterUnversity of Nevada, Las VegasSt. Elizabeth’s HospitalOutcomes & Pharmacy Practice, University of TexasYale Uni School of MedicineBronxCare Hospital CenterNorth Shore Medical CenterOBJECTIVES/SPECIFIC AIMS: Cancer related pain presents a significant risk for opioid abuse among cancer survivors and contributes to the current opioid crisis. Nearly 90% of breast cancer patients have been reported to have cancer-related pain requiring treatment. Opioids, in combination with NSAIDs, have been widely used for pain management in this population despite the risk of abuse. Long-term NSAID use due to their antineoplastic and neuroprotective effects may offer additional protective effects against opioid abuse. Here, we assess the relationship between NSAID use and opioid abuse among breast cancer patients. METHODS/STUDY POPULATION: Using ICD-9-CM codes, we identified and selected women aged >18 years with breast cancer from the National Inpatient Sample (NIS). Our primary predictor was a history of long-term NSAID use. Opioid abuse was the primary outcome of interest. Secondary outcomes were inpatient mortality and length of stay. Multivariable regression models were employed in assessing the association between predictors and outcomes while adjusting for relevant covariates. RESULTS/ANTICIPATED RESULTS: Among 170,644 women with breast cancer, 7,838 (4.6%) reported a history of long-term NSAID use. Patients with a history of long-term NSAID use had lower odds of opioid abuse (aOR 0.53; 95% CI [0.32-0.88]) and in-hospital mortality (aOR 0.52; 95% CI [0.45-0.60]) and were likely to have shorter hospital stay (7.12 vs. 8.11 days) compared to women with no history of long-term NSAID use. DISCUSSION/SIGNIFICANCE OF IMPACT: Long-term NSAID use may offer a protective effect against opioid abuse and improve in-hospital outcomes translating to better quality of life and healthcare utilization indices among breast cancer patients.https://www.cambridge.org/core/product/identifier/S2059866119000955/type/journal_article |
| spellingShingle | Nnaemeka E Onyeakusi Semiu Gbadamosi Fahad Mukhtar Chinelo Orji Ugochukwu Ugwuowo Onyenikewe Igbeta Adeyinka Adejumo 3002 Effect of Long-Term NSAID Use on Opioid Abuse and Health Outcomes among Breast Cancer Patients Journal of Clinical and Translational Science |
| title | 3002 Effect of Long-Term NSAID Use on Opioid Abuse and Health Outcomes among Breast Cancer Patients |
| title_full | 3002 Effect of Long-Term NSAID Use on Opioid Abuse and Health Outcomes among Breast Cancer Patients |
| title_fullStr | 3002 Effect of Long-Term NSAID Use on Opioid Abuse and Health Outcomes among Breast Cancer Patients |
| title_full_unstemmed | 3002 Effect of Long-Term NSAID Use on Opioid Abuse and Health Outcomes among Breast Cancer Patients |
| title_short | 3002 Effect of Long-Term NSAID Use on Opioid Abuse and Health Outcomes among Breast Cancer Patients |
| title_sort | 3002 effect of long term nsaid use on opioid abuse and health outcomes among breast cancer patients |
| url | https://www.cambridge.org/core/product/identifier/S2059866119000955/type/journal_article |
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