Hepatitis B screening and vaccination strategies for newly arrived adult Canadian immigrants and refugees: a cost-effectiveness analysis.
BACKGROUND:Immigrants have increased mortality from hepatocellular carcinoma as compared to the host populations, primarily due to undetected chronic hepatitis B virus (HBV) infection. Despite this, there are no systematic programs in most immigrant-receiving countries to screen for chronic HBV infe...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3799697?pdf=render |
| _version_ | 1818318797317079040 |
|---|---|
| author | Carmine Rossi Kevin Schwartzman Olivia Oxlade Marina B Klein Chris Greenaway |
| author_facet | Carmine Rossi Kevin Schwartzman Olivia Oxlade Marina B Klein Chris Greenaway |
| author_sort | Carmine Rossi |
| collection | DOAJ |
| description | BACKGROUND:Immigrants have increased mortality from hepatocellular carcinoma as compared to the host populations, primarily due to undetected chronic hepatitis B virus (HBV) infection. Despite this, there are no systematic programs in most immigrant-receiving countries to screen for chronic HBV infection and immigrants are not routinely offered HBV vaccination outside of the universal childhood vaccination program. METHODS AND FINDINGS:A cost-effective analysis was performed to compare four HBV screening and vaccination strategies with no intervention in a hypothetical cohort of newly-arriving adult Canadian immigrants. The strategies considered were a) universal vaccination, b) screening for prior immunity and vaccination, c) chronic HBV screening and treatment, and d) combined screening for chronic HBV and prior immunity, treatment and vaccination. The analysis was performed from a societal perspective, using a Markov model. Seroprevalence estimates, annual transition probabilities, health-care costs (in Canadian dollars), and utilities were obtained from the published literature. Acute HBV infection, mortality from chronic HBV, quality-adjusted life years (QALYs), and costs were modeled over the lifetime of the cohort of immigrants. Costs and QALYs were discounted at a rate of 3% per year. Screening for chronic HBV infection, and offering treatment if indicated, was found to be the most cost-effective intervention and was estimated to cost $40,880 per additional QALY gained, relative to no intervention. This strategy was most cost-effective for immigrants < 55 years of age and would cost < $50,000 per additional QALY gained for immigrants from areas where HBV seroprevalence is ≥ 3%. Strategies that included HBV vaccination were either prohibitively expensive or dominated by the chronic HBV screening strategy. CONCLUSIONS:Screening for chronic HBV infection from regions where most Canadian immigrants originate, except for Latin America and the Middle East, was found to be reasonably cost-effective and has the potential to reduce HBV-associated morbidity and mortality. |
| first_indexed | 2024-12-13T09:58:56Z |
| format | Article |
| id | doaj.art-9c8f1062077d4d79ba46621effec56cb |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T09:58:56Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9c8f1062077d4d79ba46621effec56cb2022-12-21T23:51:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7854810.1371/journal.pone.0078548Hepatitis B screening and vaccination strategies for newly arrived adult Canadian immigrants and refugees: a cost-effectiveness analysis.Carmine RossiKevin SchwartzmanOlivia OxladeMarina B KleinChris GreenawayBACKGROUND:Immigrants have increased mortality from hepatocellular carcinoma as compared to the host populations, primarily due to undetected chronic hepatitis B virus (HBV) infection. Despite this, there are no systematic programs in most immigrant-receiving countries to screen for chronic HBV infection and immigrants are not routinely offered HBV vaccination outside of the universal childhood vaccination program. METHODS AND FINDINGS:A cost-effective analysis was performed to compare four HBV screening and vaccination strategies with no intervention in a hypothetical cohort of newly-arriving adult Canadian immigrants. The strategies considered were a) universal vaccination, b) screening for prior immunity and vaccination, c) chronic HBV screening and treatment, and d) combined screening for chronic HBV and prior immunity, treatment and vaccination. The analysis was performed from a societal perspective, using a Markov model. Seroprevalence estimates, annual transition probabilities, health-care costs (in Canadian dollars), and utilities were obtained from the published literature. Acute HBV infection, mortality from chronic HBV, quality-adjusted life years (QALYs), and costs were modeled over the lifetime of the cohort of immigrants. Costs and QALYs were discounted at a rate of 3% per year. Screening for chronic HBV infection, and offering treatment if indicated, was found to be the most cost-effective intervention and was estimated to cost $40,880 per additional QALY gained, relative to no intervention. This strategy was most cost-effective for immigrants < 55 years of age and would cost < $50,000 per additional QALY gained for immigrants from areas where HBV seroprevalence is ≥ 3%. Strategies that included HBV vaccination were either prohibitively expensive or dominated by the chronic HBV screening strategy. CONCLUSIONS:Screening for chronic HBV infection from regions where most Canadian immigrants originate, except for Latin America and the Middle East, was found to be reasonably cost-effective and has the potential to reduce HBV-associated morbidity and mortality.http://europepmc.org/articles/PMC3799697?pdf=render |
| spellingShingle | Carmine Rossi Kevin Schwartzman Olivia Oxlade Marina B Klein Chris Greenaway Hepatitis B screening and vaccination strategies for newly arrived adult Canadian immigrants and refugees: a cost-effectiveness analysis. PLoS ONE |
| title | Hepatitis B screening and vaccination strategies for newly arrived adult Canadian immigrants and refugees: a cost-effectiveness analysis. |
| title_full | Hepatitis B screening and vaccination strategies for newly arrived adult Canadian immigrants and refugees: a cost-effectiveness analysis. |
| title_fullStr | Hepatitis B screening and vaccination strategies for newly arrived adult Canadian immigrants and refugees: a cost-effectiveness analysis. |
| title_full_unstemmed | Hepatitis B screening and vaccination strategies for newly arrived adult Canadian immigrants and refugees: a cost-effectiveness analysis. |
| title_short | Hepatitis B screening and vaccination strategies for newly arrived adult Canadian immigrants and refugees: a cost-effectiveness analysis. |
| title_sort | hepatitis b screening and vaccination strategies for newly arrived adult canadian immigrants and refugees a cost effectiveness analysis |
| url | http://europepmc.org/articles/PMC3799697?pdf=render |
| work_keys_str_mv | AT carminerossi hepatitisbscreeningandvaccinationstrategiesfornewlyarrivedadultcanadianimmigrantsandrefugeesacosteffectivenessanalysis AT kevinschwartzman hepatitisbscreeningandvaccinationstrategiesfornewlyarrivedadultcanadianimmigrantsandrefugeesacosteffectivenessanalysis AT oliviaoxlade hepatitisbscreeningandvaccinationstrategiesfornewlyarrivedadultcanadianimmigrantsandrefugeesacosteffectivenessanalysis AT marinabklein hepatitisbscreeningandvaccinationstrategiesfornewlyarrivedadultcanadianimmigrantsandrefugeesacosteffectivenessanalysis AT chrisgreenaway hepatitisbscreeningandvaccinationstrategiesfornewlyarrivedadultcanadianimmigrantsandrefugeesacosteffectivenessanalysis |