Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma

Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma

Summary: Pancreatic ductal adenocarcinoma (PDA) orchestrates a suppressive tumor microenvironment that fosters immunotherapy resistance. Tumor-associated macrophages (TAMs) are the principal immune cell infiltrating PDA and are heterogeneous. Here, by employing macrophage fate-mapping approaches and...

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Bibliographic Details
Main Authors: Michael T. Patterson, Adam L. Burrack, Yingzheng Xu, Grant H. Hickok, Zoe C. Schmiechen, Samuel Becker, Eduardo Cruz-Hinojoza, Patricia R. Schrank, Ainsley E. Kennedy, Maria M. Firulyova, Ebony A. Miller, Konstantin Zaitsev, Jesse W. Williams, Ingunn M. Stromnes
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472300743X

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