Prospects of diagnostic and prognostic biomarkers of pyometra in canine
Pyometra is one of the most common uterine pathologies of intact bitch at middle to advanced age. In the early stages, the disease shows subtle changes, making diagnosis a challenge. In contrast, at later stages, it manifests as potentially life-threatening systemic inflammatory response syndrome. U...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Asian Pacific Journal of Reproduction |
| Subjects: | |
| Online Access: | http://www.apjr.net/article.asp?issn=2305-0500;year=2020;volume=9;issue=4;spage=166;epage=173;aulast=Singh |
| _version_ | 1818436084206403584 |
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| author | Laishram Kipjen Singh Manas Kumar Patra Girish Kumar Mishra Abhishek Chandra Saxena Ujjwal Kumar De Sanjay Kumar Singh Harendra Kumar Krishnaswamy Narayanan |
| author_facet | Laishram Kipjen Singh Manas Kumar Patra Girish Kumar Mishra Abhishek Chandra Saxena Ujjwal Kumar De Sanjay Kumar Singh Harendra Kumar Krishnaswamy Narayanan |
| author_sort | Laishram Kipjen Singh |
| collection | DOAJ |
| description | Pyometra is one of the most common uterine pathologies of intact bitch at middle to advanced age. In the early stages, the disease shows subtle changes, making diagnosis a challenge. In contrast, at later stages, it manifests as potentially life-threatening systemic inflammatory response syndrome. Ultrasonographic examination of the uterus aids in the diagnosis, although it has limitation in ascertaining the clinical severity of pyometra. Moreover, differentiation of cystic endometrial hyperplasia from pyometra could not be discerned with greater accuracy. Therefore, false negative diagnosis of pyometra patients leads to development of systemic inflammatory response, which delays administration of therapies and results in deaths during early course of treatment. Further, indiscriminate use of broad-spectrum antimicrobials at higher dose in false positive cases considerably contributes to the rising pool of drug resistant pathogens, thereby increasing the risk of case fatality due to sepsis in a long-term. Monitoring the circulating pro-inflammatory cytokines, acute phase proteins, endotoxin, growth factors and inflammatory mediators is the current trend in pyometra research, especially for developing diagnostic and prognostic biomarkers. The present review deals with the prospects of developing diagnostic and prognostic biomarkers in the canine pyometra. |
| first_indexed | 2024-12-14T17:03:09Z |
| format | Article |
| id | doaj.art-9c9098d26c3a4b92bbacf2808af8b829 |
| institution | Directory Open Access Journal |
| issn | 2305-0500 2305-0519 |
| language | English |
| last_indexed | 2024-12-14T17:03:09Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Reproduction |
| spelling | doaj.art-9c9098d26c3a4b92bbacf2808af8b8292022-12-21T22:53:47ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Reproduction2305-05002305-05192020-01-019416617310.4103/2305-0500.288584Prospects of diagnostic and prognostic biomarkers of pyometra in canineLaishram Kipjen SinghManas Kumar PatraGirish Kumar MishraAbhishek Chandra SaxenaUjjwal Kumar DeSanjay Kumar SinghHarendra KumarKrishnaswamy NarayananPyometra is one of the most common uterine pathologies of intact bitch at middle to advanced age. In the early stages, the disease shows subtle changes, making diagnosis a challenge. In contrast, at later stages, it manifests as potentially life-threatening systemic inflammatory response syndrome. Ultrasonographic examination of the uterus aids in the diagnosis, although it has limitation in ascertaining the clinical severity of pyometra. Moreover, differentiation of cystic endometrial hyperplasia from pyometra could not be discerned with greater accuracy. Therefore, false negative diagnosis of pyometra patients leads to development of systemic inflammatory response, which delays administration of therapies and results in deaths during early course of treatment. Further, indiscriminate use of broad-spectrum antimicrobials at higher dose in false positive cases considerably contributes to the rising pool of drug resistant pathogens, thereby increasing the risk of case fatality due to sepsis in a long-term. Monitoring the circulating pro-inflammatory cytokines, acute phase proteins, endotoxin, growth factors and inflammatory mediators is the current trend in pyometra research, especially for developing diagnostic and prognostic biomarkers. The present review deals with the prospects of developing diagnostic and prognostic biomarkers in the canine pyometra.http://www.apjr.net/article.asp?issn=2305-0500;year=2020;volume=9;issue=4;spage=166;epage=173;aulast=Singhpyometra; systemic inflammatory response; acute-phase proteins; prostaglandin f metabolite; canine |
| spellingShingle | Laishram Kipjen Singh Manas Kumar Patra Girish Kumar Mishra Abhishek Chandra Saxena Ujjwal Kumar De Sanjay Kumar Singh Harendra Kumar Krishnaswamy Narayanan Prospects of diagnostic and prognostic biomarkers of pyometra in canine Asian Pacific Journal of Reproduction pyometra; systemic inflammatory response; acute-phase proteins; prostaglandin f metabolite; canine |
| title | Prospects of diagnostic and prognostic biomarkers of pyometra in canine |
| title_full | Prospects of diagnostic and prognostic biomarkers of pyometra in canine |
| title_fullStr | Prospects of diagnostic and prognostic biomarkers of pyometra in canine |
| title_full_unstemmed | Prospects of diagnostic and prognostic biomarkers of pyometra in canine |
| title_short | Prospects of diagnostic and prognostic biomarkers of pyometra in canine |
| title_sort | prospects of diagnostic and prognostic biomarkers of pyometra in canine |
| topic | pyometra; systemic inflammatory response; acute-phase proteins; prostaglandin f metabolite; canine |
| url | http://www.apjr.net/article.asp?issn=2305-0500;year=2020;volume=9;issue=4;spage=166;epage=173;aulast=Singh |
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