Scopoletin: Anticancer potential and mechanism of action
Cancer is considered a leading cause of death worldwide due to its high morbidity and mortality rate. Conventional treatments for cancer therapy, such as chemotherapy, and radiotherapy, have been hampered by their side effects. Natural product-derived plants have been used for decades to treat disea...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
| Subjects: | |
| Online Access: | http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=1;spage=1;epage=8;aulast=Meilawati |
| _version_ | 1831880421477974016 |
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| author | Lia Meilawati Rita Marleta Dewi Aprilia Nur Tasfiyati Abdi Wira Septama Lucia Dwi Antika |
| author_facet | Lia Meilawati Rita Marleta Dewi Aprilia Nur Tasfiyati Abdi Wira Septama Lucia Dwi Antika |
| author_sort | Lia Meilawati |
| collection | DOAJ |
| description | Cancer is considered a leading cause of death worldwide due to its high morbidity and mortality rate. Conventional treatments for cancer therapy, such as chemotherapy, and radiotherapy, have been hampered by their side effects. Natural product-derived plants have been used for decades to treat diseases. Compared to conventional therapy, natural product has the potential to be effective against cancer with fewer side effects. This current review discussed the potential of scopoletin, a coumarin present in many edible plants, which elicits anticancer properties through multiple mechanisms, including modulating cell cycle arrest, inducing apoptosis, and regulating multiple signaling pathways. Understanding these mechanisms highlights the potential of scopoletin as a candidate for chemoprevention and chemotherapy. |
| first_indexed | 2024-04-10T09:57:52Z |
| format | Article |
| id | doaj.art-9c91bd7d0dfa4595be19b8803eb43f6c |
| institution | Directory Open Access Journal |
| issn | 2221-1691 2588-9222 |
| language | English |
| last_indexed | 2025-03-21T22:02:49Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-9c91bd7d0dfa4595be19b8803eb43f6c2024-05-25T11:45:07ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912588-92222023-01-011311810.4103/2221-1691.367685Scopoletin: Anticancer potential and mechanism of actionLia MeilawatiRita Marleta DewiAprilia Nur TasfiyatiAbdi Wira SeptamaLucia Dwi AntikaCancer is considered a leading cause of death worldwide due to its high morbidity and mortality rate. Conventional treatments for cancer therapy, such as chemotherapy, and radiotherapy, have been hampered by their side effects. Natural product-derived plants have been used for decades to treat diseases. Compared to conventional therapy, natural product has the potential to be effective against cancer with fewer side effects. This current review discussed the potential of scopoletin, a coumarin present in many edible plants, which elicits anticancer properties through multiple mechanisms, including modulating cell cycle arrest, inducing apoptosis, and regulating multiple signaling pathways. Understanding these mechanisms highlights the potential of scopoletin as a candidate for chemoprevention and chemotherapy.http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=1;spage=1;epage=8;aulast=Meilawatiscopoletin; coumarin; anticancer; signaling pathway; cell cycle arrest; apoptosis |
| spellingShingle | Lia Meilawati Rita Marleta Dewi Aprilia Nur Tasfiyati Abdi Wira Septama Lucia Dwi Antika Scopoletin: Anticancer potential and mechanism of action Asian Pacific Journal of Tropical Biomedicine scopoletin; coumarin; anticancer; signaling pathway; cell cycle arrest; apoptosis |
| title | Scopoletin: Anticancer potential and mechanism of action |
| title_full | Scopoletin: Anticancer potential and mechanism of action |
| title_fullStr | Scopoletin: Anticancer potential and mechanism of action |
| title_full_unstemmed | Scopoletin: Anticancer potential and mechanism of action |
| title_short | Scopoletin: Anticancer potential and mechanism of action |
| title_sort | scopoletin anticancer potential and mechanism of action |
| topic | scopoletin; coumarin; anticancer; signaling pathway; cell cycle arrest; apoptosis |
| url | http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=1;spage=1;epage=8;aulast=Meilawati |
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