Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity

Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity

Summary: Live-attenuated vaccines are generally highly effective. Here, we aimed to develop one against SARS-CoV-2, based on the identification of three types of temperature-sensitive (TS) strains with mutations in nonstructural proteins (nsp), impaired proliferation at 37°C–39°C, and the capacity t...

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Bibliographic Details
Main Authors:	Akiho Yoshida, Shinya Okamura, Shiho Torii, Sayuri Komatsu, Paola Miyazato, Hitomi Sasaki, Shiori Ueno, Hidehiko Suzuki, Wataru Kamitani, Chikako Ono, Yoshiharu Matsuura, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina
Format:	Article
Language:	English
Published:	Elsevier 2022-11-01
Series:	iScience
Subjects:	Biological sciences Genomics Immune response Immunology Virology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004222016844

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