Causal relationship between atrial fibrillation/warfarin and cutaneous melanoma: a two-sample Mendelian randomization study
PurposeIn recent years, the relationship between malignant tumors and atrial fibrillation has attracted more and more attention. Atrial fibrillation can also cause a series of adverse events, such as the risk of thromboembolism. Also, Warfarin is often used here. But, the relationship between cutane...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-03-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1336849/full |
| _version_ | 1797277165089193984 |
|---|---|
| author | Wang Xiaowu Zhou Qiang Han Yike Zhixuan Wu Jin Yiheng Chen Xuemei Lin Sen Chen Jiong |
| author_facet | Wang Xiaowu Zhou Qiang Han Yike Zhixuan Wu Jin Yiheng Chen Xuemei Lin Sen Chen Jiong |
| author_sort | Wang Xiaowu |
| collection | DOAJ |
| description | PurposeIn recent years, the relationship between malignant tumors and atrial fibrillation has attracted more and more attention. Atrial fibrillation can also cause a series of adverse events, such as the risk of thromboembolism. Also, Warfarin is often used here. But, the relationship between cutaneous melanoma and atrial fibrillation, and between cutaneous melanoma and warfarin is still unclear. Therefore, we used a two-sample Mendelian randomization to assess the causal relationship between atrial fibrillation/warfarin and cutaneous melanoma (cM).MethodsFirstly, atrial fibrillation (ukb-b-11550; nCase = 3,518, nControl = 459,415) and warfarin (ukb-b-13248; nCase = 4,623, nControl = 458,310) as exposures, with genome-wide association studies (GWAS) data from the United Kingdom Biobank. And cM (ieu-b-4969; nCase = 3,751, nControl = 372,016) as outcome, with GWAS data from the IEU Open GWAS project. Subsequently, single-nucleotide polymorphisms (SNPs) were filtered from GWAS studies using quality control measures. In addition, two-sample Mendelian randomization (MR) analysis was performed to explore the causal relationship between atrial fibrillation or warfarin and cM and used inverse variance weighting (IVW) as the primary analytical method. Finally, relevant heterogeneity and sensitivity analysis were performed to ensure the accuracy of the results.ResultsA causal relationship between atrial fibrillation and cutaneous melanoma was observed, and between warfarin and cutaneous melanoma.ConclusionThe atrial fibrillation may play a causal role in the development of cutaneous melanoma, but the mechanism and the causal relationship between warfarin and cutaneous melanoma needs to be further elucidated. |
| first_indexed | 2024-03-07T15:43:46Z |
| format | Article |
| id | doaj.art-9c941ff0c62f4e5d8b7271caa12801ed |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-07T15:43:46Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-9c941ff0c62f4e5d8b7271caa12801ed2024-03-05T05:07:27ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-03-011110.3389/fmed.2024.13368491336849Causal relationship between atrial fibrillation/warfarin and cutaneous melanoma: a two-sample Mendelian randomization studyWang Xiaowu0Zhou Qiang1Han Yike2Zhixuan Wu3Jin Yiheng4Chen Xuemei5Lin Sen6Chen Jiong7Department of Burns and Skin Repair Surgery, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People’s Hospital), Wenzhou, ChinaDepartment of Otolaryngology, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People’s Hospital), Wenzhou, ChinaDepartment of Gynaecology and Obstetrics, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People’s Hospital), Wenzhou, ChinaDepartment of Nail and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaCollege of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of Otolaryngology, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People’s Hospital), Wenzhou, ChinaDepartment of Burns and Skin Repair Surgery, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People’s Hospital), Wenzhou, ChinaPurposeIn recent years, the relationship between malignant tumors and atrial fibrillation has attracted more and more attention. Atrial fibrillation can also cause a series of adverse events, such as the risk of thromboembolism. Also, Warfarin is often used here. But, the relationship between cutaneous melanoma and atrial fibrillation, and between cutaneous melanoma and warfarin is still unclear. Therefore, we used a two-sample Mendelian randomization to assess the causal relationship between atrial fibrillation/warfarin and cutaneous melanoma (cM).MethodsFirstly, atrial fibrillation (ukb-b-11550; nCase = 3,518, nControl = 459,415) and warfarin (ukb-b-13248; nCase = 4,623, nControl = 458,310) as exposures, with genome-wide association studies (GWAS) data from the United Kingdom Biobank. And cM (ieu-b-4969; nCase = 3,751, nControl = 372,016) as outcome, with GWAS data from the IEU Open GWAS project. Subsequently, single-nucleotide polymorphisms (SNPs) were filtered from GWAS studies using quality control measures. In addition, two-sample Mendelian randomization (MR) analysis was performed to explore the causal relationship between atrial fibrillation or warfarin and cM and used inverse variance weighting (IVW) as the primary analytical method. Finally, relevant heterogeneity and sensitivity analysis were performed to ensure the accuracy of the results.ResultsA causal relationship between atrial fibrillation and cutaneous melanoma was observed, and between warfarin and cutaneous melanoma.ConclusionThe atrial fibrillation may play a causal role in the development of cutaneous melanoma, but the mechanism and the causal relationship between warfarin and cutaneous melanoma needs to be further elucidated.https://www.frontiersin.org/articles/10.3389/fmed.2024.1336849/fullatrial fibrillationwarfarincutaneous melanomaMendelian randomization studysensitivity analysis |
| spellingShingle | Wang Xiaowu Zhou Qiang Han Yike Zhixuan Wu Jin Yiheng Chen Xuemei Lin Sen Chen Jiong Causal relationship between atrial fibrillation/warfarin and cutaneous melanoma: a two-sample Mendelian randomization study Frontiers in Medicine atrial fibrillation warfarin cutaneous melanoma Mendelian randomization study sensitivity analysis |
| title | Causal relationship between atrial fibrillation/warfarin and cutaneous melanoma: a two-sample Mendelian randomization study |
| title_full | Causal relationship between atrial fibrillation/warfarin and cutaneous melanoma: a two-sample Mendelian randomization study |
| title_fullStr | Causal relationship between atrial fibrillation/warfarin and cutaneous melanoma: a two-sample Mendelian randomization study |
| title_full_unstemmed | Causal relationship between atrial fibrillation/warfarin and cutaneous melanoma: a two-sample Mendelian randomization study |
| title_short | Causal relationship between atrial fibrillation/warfarin and cutaneous melanoma: a two-sample Mendelian randomization study |
| title_sort | causal relationship between atrial fibrillation warfarin and cutaneous melanoma a two sample mendelian randomization study |
| topic | atrial fibrillation warfarin cutaneous melanoma Mendelian randomization study sensitivity analysis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1336849/full |
| work_keys_str_mv | AT wangxiaowu causalrelationshipbetweenatrialfibrillationwarfarinandcutaneousmelanomaatwosamplemendelianrandomizationstudy AT zhouqiang causalrelationshipbetweenatrialfibrillationwarfarinandcutaneousmelanomaatwosamplemendelianrandomizationstudy AT hanyike causalrelationshipbetweenatrialfibrillationwarfarinandcutaneousmelanomaatwosamplemendelianrandomizationstudy AT zhixuanwu causalrelationshipbetweenatrialfibrillationwarfarinandcutaneousmelanomaatwosamplemendelianrandomizationstudy AT jinyiheng causalrelationshipbetweenatrialfibrillationwarfarinandcutaneousmelanomaatwosamplemendelianrandomizationstudy AT chenxuemei causalrelationshipbetweenatrialfibrillationwarfarinandcutaneousmelanomaatwosamplemendelianrandomizationstudy AT linsen causalrelationshipbetweenatrialfibrillationwarfarinandcutaneousmelanomaatwosamplemendelianrandomizationstudy AT chenjiong causalrelationshipbetweenatrialfibrillationwarfarinandcutaneousmelanomaatwosamplemendelianrandomizationstudy |