A carrier-free nano-drug assembled via π–π stacking interaction for the treatment of osteoarthritis
Osteoarthritis (OA) is considered to be the most common joint disorder. Exogenous drug intervention is one of the effective means for OA treatment. Clinical applications of numerous drugs are restricted owing to the short retention as well as rapid clearance in the joint cavity. A wide variety of ca...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223006716 |
| _version_ | 1797801857537540096 |
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| author | Wanwu Dai Pan Jin Xingyan Li Jinmin Zhao Ying Lan Hongmian Li Li Zheng |
| author_facet | Wanwu Dai Pan Jin Xingyan Li Jinmin Zhao Ying Lan Hongmian Li Li Zheng |
| author_sort | Wanwu Dai |
| collection | DOAJ |
| description | Osteoarthritis (OA) is considered to be the most common joint disorder. Exogenous drug intervention is one of the effective means for OA treatment. Clinical applications of numerous drugs are restricted owing to the short retention as well as rapid clearance in the joint cavity. A wide variety of carrier-based nanodrugs have been developed, but additional carriers may bring unexpected side effects or even toxicity. Herein, by exploiting the spontaneous fluorescence of Curcumin, we designed a new carrier-free self-assembly nanomedicine Curcumin (Cur)/icariin (ICA) nanoparticles with adjustable particle size, which is composed of two small-molecule natural drugs assembled via π–π stacking interaction. Experimental results revealed that Cur/ICA NPs endowed with little cytotoxicity, high cellular uptake and sustained drug release, could inhibit secretion of inflammatory cytokines and reduce cartilage degeneration. Moreover, both the in vitro and in vivo experiments showed the NPs exerted superior synergism effects in anti-inflammatory and cartilage protection than either Cur or ICA alone, and self-monitored its retention by autofluorescence. Thus, the new self-assembly nano-drug combining Cur and ICA represents a new strategy for the treatment of osteoarthritis. |
| first_indexed | 2024-03-13T04:56:55Z |
| format | Article |
| id | doaj.art-9c95ab6a9b90431f9936593a66793351 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T04:56:55Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-9c95ab6a9b90431f9936593a667933512023-06-18T05:00:35ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-08-01164114881A carrier-free nano-drug assembled via π–π stacking interaction for the treatment of osteoarthritisWanwu Dai0Pan Jin1Xingyan Li2Jinmin Zhao3Ying Lan4Hongmian Li5Li Zheng6Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration & Collaborative Innovation Center of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Life Sciences Institute, Guangxi Medical University, Nanning 530021, China; Department of Bone and Joint Surgery, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530031, ChinaGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration & Collaborative Innovation Center of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Life Sciences Institute, Guangxi Medical University, Nanning 530021, ChinaDepartment of Bone and Joint Surgery, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530031, ChinaGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration & Collaborative Innovation Center of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Life Sciences Institute, Guangxi Medical University, Nanning 530021, ChinaGuangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration & Collaborative Innovation Center of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Life Sciences Institute, Guangxi Medical University, Nanning 530021, China; Corresponding authors.Department of Plastic and Reconstructive Surgery, The People’s Hospital of Guangxi Zhuang Autonomous Region & Research Center of Medical Sciences, Guangxi Academy of Medical Sciences, Nanning 530021, China; Corresponding authors.Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration & Collaborative Innovation Center of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Life Sciences Institute, Guangxi Medical University, Nanning 530021, China; Guangxi Key Laboratory of Regenerative Medicine, Department of Orthopedics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China; Corresponding author at: Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration & Collaborative Innovation Center of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Life Sciences Institute, Guangxi Medical University, Nanning 530021, China.Osteoarthritis (OA) is considered to be the most common joint disorder. Exogenous drug intervention is one of the effective means for OA treatment. Clinical applications of numerous drugs are restricted owing to the short retention as well as rapid clearance in the joint cavity. A wide variety of carrier-based nanodrugs have been developed, but additional carriers may bring unexpected side effects or even toxicity. Herein, by exploiting the spontaneous fluorescence of Curcumin, we designed a new carrier-free self-assembly nanomedicine Curcumin (Cur)/icariin (ICA) nanoparticles with adjustable particle size, which is composed of two small-molecule natural drugs assembled via π–π stacking interaction. Experimental results revealed that Cur/ICA NPs endowed with little cytotoxicity, high cellular uptake and sustained drug release, could inhibit secretion of inflammatory cytokines and reduce cartilage degeneration. Moreover, both the in vitro and in vivo experiments showed the NPs exerted superior synergism effects in anti-inflammatory and cartilage protection than either Cur or ICA alone, and self-monitored its retention by autofluorescence. Thus, the new self-assembly nano-drug combining Cur and ICA represents a new strategy for the treatment of osteoarthritis.http://www.sciencedirect.com/science/article/pii/S0753332223006716Nano-drugπ–π stacking interactionOsteoarthritisCurcuminIcariin |
| spellingShingle | Wanwu Dai Pan Jin Xingyan Li Jinmin Zhao Ying Lan Hongmian Li Li Zheng A carrier-free nano-drug assembled via π–π stacking interaction for the treatment of osteoarthritis Biomedicine & Pharmacotherapy Nano-drug π–π stacking interaction Osteoarthritis Curcumin Icariin |
| title | A carrier-free nano-drug assembled via π–π stacking interaction for the treatment of osteoarthritis |
| title_full | A carrier-free nano-drug assembled via π–π stacking interaction for the treatment of osteoarthritis |
| title_fullStr | A carrier-free nano-drug assembled via π–π stacking interaction for the treatment of osteoarthritis |
| title_full_unstemmed | A carrier-free nano-drug assembled via π–π stacking interaction for the treatment of osteoarthritis |
| title_short | A carrier-free nano-drug assembled via π–π stacking interaction for the treatment of osteoarthritis |
| title_sort | carrier free nano drug assembled via π π stacking interaction for the treatment of osteoarthritis |
| topic | Nano-drug π–π stacking interaction Osteoarthritis Curcumin Icariin |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223006716 |
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