Characterization of Staphylococcus aureus isolated from patients with burns in a regional burn center, Southeastern China
Abstract Background S.aureus is a predominant pathogen that causes infection in critically ill patients, but little information exists regarding the characterization of S. aureus from different sources in burn patients in southeastern China. Methods We enrolled 125 patients with S. aureus infection...
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| Format: | Article |
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BMC
2018-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-018-2955-6 |
| _version_ | 1819069619245154304 |
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| author | Kaisen Chen Shirong Lin Peiqun Li Qiuyue Song Dong Luo Tao Liu Lingbing Zeng Wei Zhang |
| author_facet | Kaisen Chen Shirong Lin Peiqun Li Qiuyue Song Dong Luo Tao Liu Lingbing Zeng Wei Zhang |
| author_sort | Kaisen Chen |
| collection | DOAJ |
| description | Abstract Background S.aureus is a predominant pathogen that causes infection in critically ill patients, but little information exists regarding the characterization of S. aureus from different sources in burn patients in southeastern China. Methods We enrolled 125 patients with S. aureus infection in burns center between Jan 2014 and Dec 2015. S. aureus isolates were characterized by antimicrobial susceptibility test, toxin gene detection, and molecular typing with multilocus sequence type, staphylococcal protein A (spa) type, and staphylococcal cassette chromosome mec (SCCmec) type. Results Sixty-eight MRSA were isolated from SSTI and 31 from non-SSTI patients, respectively. Overall, the drug-resistant ability of S. aureus isolated from SSTI was higher than that from non-SSTI groups. SCCmecIII-CC239-t030 was the most common clone (38 from SSTIs, and 8 from non-SSTIs). Seg was the most common enterotoxin gene (21 from SSTIs and 33 from non-SSTIs). Isolates from SSTIs was more likely to carry seb (P = 0.04), while those from non-SSTIs tended to carry sea and seg (P = 0.002 and 0.01, respectively). Although isolates carried four hemolysin genes, there was no significant difference between them (P > 0.05). Conclusion SCCmecIII-CC239-t030 was the most common clone in Jiangxi burns center, China. The molecular characterization of S. aureus was quite different between SSTI and non-SSTI groups. |
| first_indexed | 2024-12-21T16:52:55Z |
| format | Article |
| id | doaj.art-9c9683884ea24076aceaf76ff3701083 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-21T16:52:55Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-9c9683884ea24076aceaf76ff37010832022-12-21T18:56:50ZengBMCBMC Infectious Diseases1471-23342018-01-011811710.1186/s12879-018-2955-6Characterization of Staphylococcus aureus isolated from patients with burns in a regional burn center, Southeastern ChinaKaisen Chen0Shirong Lin1Peiqun Li2Qiuyue Song3Dong Luo4Tao Liu5Lingbing Zeng6Wei Zhang7Department of clinical laboratory, The first Affiliated Hospital of Nanchang universityDepartment of emergency, The first Affiliated Hospital of Nanchang UniversityThe College of Public Health of Nanchang UniversityThe College of Public Health of Nanchang UniversityDepartment of emergency, The first Affiliated Hospital of Nanchang UniversityDepartment of respiration, The first Affiliated Hospital of Nanchang UniversityDepartment of respiration, The first Affiliated Hospital of Nanchang UniversityDepartment of respiration, The first Affiliated Hospital of Nanchang UniversityAbstract Background S.aureus is a predominant pathogen that causes infection in critically ill patients, but little information exists regarding the characterization of S. aureus from different sources in burn patients in southeastern China. Methods We enrolled 125 patients with S. aureus infection in burns center between Jan 2014 and Dec 2015. S. aureus isolates were characterized by antimicrobial susceptibility test, toxin gene detection, and molecular typing with multilocus sequence type, staphylococcal protein A (spa) type, and staphylococcal cassette chromosome mec (SCCmec) type. Results Sixty-eight MRSA were isolated from SSTI and 31 from non-SSTI patients, respectively. Overall, the drug-resistant ability of S. aureus isolated from SSTI was higher than that from non-SSTI groups. SCCmecIII-CC239-t030 was the most common clone (38 from SSTIs, and 8 from non-SSTIs). Seg was the most common enterotoxin gene (21 from SSTIs and 33 from non-SSTIs). Isolates from SSTIs was more likely to carry seb (P = 0.04), while those from non-SSTIs tended to carry sea and seg (P = 0.002 and 0.01, respectively). Although isolates carried four hemolysin genes, there was no significant difference between them (P > 0.05). Conclusion SCCmecIII-CC239-t030 was the most common clone in Jiangxi burns center, China. The molecular characterization of S. aureus was quite different between SSTI and non-SSTI groups.http://link.springer.com/article/10.1186/s12879-018-2955-6S. aureusMolecular epidemiologyBurnsChina |
| spellingShingle | Kaisen Chen Shirong Lin Peiqun Li Qiuyue Song Dong Luo Tao Liu Lingbing Zeng Wei Zhang Characterization of Staphylococcus aureus isolated from patients with burns in a regional burn center, Southeastern China BMC Infectious Diseases S. aureus Molecular epidemiology Burns China |
| title | Characterization of Staphylococcus aureus isolated from patients with burns in a regional burn center, Southeastern China |
| title_full | Characterization of Staphylococcus aureus isolated from patients with burns in a regional burn center, Southeastern China |
| title_fullStr | Characterization of Staphylococcus aureus isolated from patients with burns in a regional burn center, Southeastern China |
| title_full_unstemmed | Characterization of Staphylococcus aureus isolated from patients with burns in a regional burn center, Southeastern China |
| title_short | Characterization of Staphylococcus aureus isolated from patients with burns in a regional burn center, Southeastern China |
| title_sort | characterization of staphylococcus aureus isolated from patients with burns in a regional burn center southeastern china |
| topic | S. aureus Molecular epidemiology Burns China |
| url | http://link.springer.com/article/10.1186/s12879-018-2955-6 |
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