Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases
Steroidal glycoalkaloids (SGAs) accumulate in Solanum, but their hydroxylating enzymes are unknown. Here, the authors report 2-OXOGLUTARATE DEPENDENT DIOXYGENASE enzymes that catalyze the committed hydroxylation steps in the biosynthesis of leptinine insecticidal compounds in wild potato or non-bitt...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13211-4 |
| _version_ | 1819194711063134208 |
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| author | Pablo D. Cárdenas Prashant D. Sonawane Uwe Heinig Adam Jozwiak Sayantan Panda Bekele Abebie Yana Kazachkova Margarita Pliner Tamar Unger Dalia Wolf Itai Ofner Ester Vilaprinyo Sagit Meir Olga Davydov Amit Gal-on Saul Burdman Ashok Giri Dani Zamir Tali Scherf Jedrzej Szymanski Ilana Rogachev Asaph Aharoni |
| author_facet | Pablo D. Cárdenas Prashant D. Sonawane Uwe Heinig Adam Jozwiak Sayantan Panda Bekele Abebie Yana Kazachkova Margarita Pliner Tamar Unger Dalia Wolf Itai Ofner Ester Vilaprinyo Sagit Meir Olga Davydov Amit Gal-on Saul Burdman Ashok Giri Dani Zamir Tali Scherf Jedrzej Szymanski Ilana Rogachev Asaph Aharoni |
| author_sort | Pablo D. Cárdenas |
| collection | DOAJ |
| description | Steroidal glycoalkaloids (SGAs) accumulate in Solanum, but their hydroxylating enzymes are unknown. Here, the authors report 2-OXOGLUTARATE DEPENDENT DIOXYGENASE enzymes that catalyze the committed hydroxylation steps in the biosynthesis of leptinine insecticidal compounds in wild potato or non-bitter SGAs in cultivated tomato. |
| first_indexed | 2024-12-23T02:01:12Z |
| format | Article |
| id | doaj.art-9c9712e24c4a476fbbcb98c2daa326a1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:01:12Z |
| publishDate | 2019-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9c9712e24c4a476fbbcb98c2daa326a12022-12-21T18:03:59ZengNature PortfolioNature Communications2041-17232019-11-0110111310.1038/s41467-019-13211-4Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenasesPablo D. Cárdenas0Prashant D. Sonawane1Uwe Heinig2Adam Jozwiak3Sayantan Panda4Bekele Abebie5Yana Kazachkova6Margarita Pliner7Tamar Unger8Dalia Wolf9Itai Ofner10Ester Vilaprinyo11Sagit Meir12Olga Davydov13Amit Gal-on14Saul Burdman15Ashok Giri16Dani Zamir17Tali Scherf18Jedrzej Szymanski19Ilana Rogachev20Asaph Aharoni21Department of Plant and Environmental Sciences, Weizmann Institute of ScienceDepartment of Plant and Environmental Sciences, Weizmann Institute of ScienceDepartment of Plant and Environmental Sciences, Weizmann Institute of ScienceDepartment of Plant and Environmental Sciences, Weizmann Institute of ScienceDepartment of Plant and Environmental Sciences, Weizmann Institute of ScienceDepartment of Plant Pathology and Weed Research, Agricultural Research Organization, Volcani CenterDepartment of Plant and Environmental Sciences, Weizmann Institute of ScienceDepartment of Plant and Environmental Sciences, Weizmann Institute of ScienceIsrael Structural Proteomics Centre, Weizmann Institute of ScienceDepartment of Vegetable Research, Agricultural Research Organization, Volcani CenterThe Institute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of JerusalemDepartment of Basic Medical Sciences, University of Lleida-IRBLleidaDepartment of Plant and Environmental Sciences, Weizmann Institute of ScienceDepartment of Plant and Environmental Sciences, Weizmann Institute of ScienceDepartment of Plant Pathology and Weed Research, Agricultural Research Organization, Volcani CenterDepartment of Plant Pathology and Microbiology and The Otto Warburg Minerva Center for Agricultural Biotechnology, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of JerusalemPlant Molecular Biology Unit, Division of Biochemical Sciences, Council of Scientific and Industrial Research-National Chemical LaboratoryThe Institute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of JerusalemNMR unit, Department of Chemical Research Support, Weizmann Institute of ScienceDepartment of Molecular Genetics, Leibniz Institute of Plant Genetics and Crop Plant Research, OT GaterslebenDepartment of Plant and Environmental Sciences, Weizmann Institute of ScienceDepartment of Plant and Environmental Sciences, Weizmann Institute of ScienceSteroidal glycoalkaloids (SGAs) accumulate in Solanum, but their hydroxylating enzymes are unknown. Here, the authors report 2-OXOGLUTARATE DEPENDENT DIOXYGENASE enzymes that catalyze the committed hydroxylation steps in the biosynthesis of leptinine insecticidal compounds in wild potato or non-bitter SGAs in cultivated tomato.https://doi.org/10.1038/s41467-019-13211-4 |
| spellingShingle | Pablo D. Cárdenas Prashant D. Sonawane Uwe Heinig Adam Jozwiak Sayantan Panda Bekele Abebie Yana Kazachkova Margarita Pliner Tamar Unger Dalia Wolf Itai Ofner Ester Vilaprinyo Sagit Meir Olga Davydov Amit Gal-on Saul Burdman Ashok Giri Dani Zamir Tali Scherf Jedrzej Szymanski Ilana Rogachev Asaph Aharoni Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases Nature Communications |
| title | Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases |
| title_full | Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases |
| title_fullStr | Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases |
| title_full_unstemmed | Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases |
| title_short | Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases |
| title_sort | pathways to defense metabolites and evading fruit bitterness in genus solanum evolved through 2 oxoglutarate dependent dioxygenases |
| url | https://doi.org/10.1038/s41467-019-13211-4 |
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