Early onset pre-eclampsia is associated with altered DNA methylation of cortisol-signalling and steroidogenic genes in the placenta.

Early onset pre-eclampsia is associated with altered DNA methylation of cortisol-signalling and steroidogenic genes in the placenta.

Placental cortisol is inactivated in normotensive pregnancies, but is frequently present in pre-eclampsia associated placentae. Since glucocorticoids are strongly associated with the programming of long-term health, we assessed DNA methylation of genes involved in cortisol signalling and bioavailabi...

Full description

Bibliographic Details
Main Authors:	Kirsten Hogg, John D Blair, Deborah E McFadden, Peter von Dadelszen, Wendy P Robinson
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23667551/pdf/?tool=EBI

Similar Items

Genome-wide mapping of imprinted differentially methylated regions by DNA methylation profiling of human placentas from triploidies
by: Yuen Ryan KC, et al.
Published: (2011-07-01)

THE DANGEROUS PLACENTA AND PRE-ECLAMPSIA, A REVIEW
by: Redman, C, et al.
Published: (2012)

Measurement of sST2 is comparable to PlGF in the diagnosis of early-onset pre-eclampsia
by: Southcombe, J, et al.
Published: (2013)

Measurement of sST2 is comparable to PlGF in the diagnosis of early-onset pre-eclampsia
by: Southcombe, J, et al.
Published: (2013)

Revisiting Steroidogenic Pathways in the Human Placenta and Primary Human Trophoblast Cells
by: Rona Karahoda, et al.
Published: (2021-02-01)

Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction.
by: Goswami, D, et al.
Published: (2006)

Prediction of Early- and Late-Onset Pre-Eclampsia in the Preclinical Stage via Placenta-Specific Extracellular miRNA Profiling
by: Angelika V. Timofeeva, et al.
Published: (2023-04-01)

Steroidogenic capacity of the placenta as a supplemental source of progesterone during pregnancy in domestic cats
by: Siemieniuch Marta J, et al.
Published: (2012-10-01)

Policy review on the management of pre-eclampsia and eclampsia by community health workers in Mozambique
by: Salésio Macuácua, et al.
Published: (2019-02-01)

Pre-eclampsia, the placenta and the maternal systemic inflammatory response--a review.
by: Redman, C, et al.
Published: (2003)

Profile of Apoptotic Marker Genes and Histopathology of the Placenta in Pregnancies with Pre-Eclampsia
by: Herlambang Herlambang, et al.
Published: (2023-06-01)

The Association Between Placenta Previa and Pre-Eclampsia: A Meta-Analysis
by: Ensiyeh Jenabi, et al.
Published: (2020-01-01)

Assessing the onset of pre-eclampsia in the hospital day unit: summary of the pre-eclampsia guideline (PRECOG II).
by: Milne, F, et al.
Published: (2009)

Prediction of complications in early-onset pre-eclampsia (PREP): development and external multinational validation of prognostic models
by: Shakila Thangaratinam, et al.
Published: (2017-03-01)

Guidelines: Assessing the onset of pre-eclampsia in the hospital day unit: Summary of the pre-eclampsia guideline (PRECOG II)
by: Milne, F, et al.
Published: (2009)

Syncytiotrophoblast Extracellular Vesicles from Pre-Eclampsia Placentas Differentially Affect Platelet Function
by: Tannetta, D, et al.
Published: (2015)

Distinct DNA Methylomes of Human Placentas Between Pre-Eclampsia and Gestational Diabetes Mellitus
by: Lan Liu, et al.
Published: (2014-11-01)

Syncytiotrophoblast Extracellular Vesicles from Pre-Eclampsia Placentas Differentially Affect Platelet Function.
by: Dionne S Tannetta, et al.
Published: (2015-01-01)

Placenta previa and pre-eclampsia: analyses of 1645 cases at Medani Maternity Hospital, Sudan
by: Ishag eAdam, et al.
Published: (2013-02-01)

Pre-eclampsia/Eclampsia
by: José Carlos Peraçoli, et al.

The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting
by: Gabriele Floris, et al.
Published: (2022-04-01)

Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells
by: Kenley Joule Pierre, et al.
Published: (2022-10-01)

Development and validation of Prediction models for Risks of complications in Early-onset Pre-eclampsia (PREP): a prospective cohort study
by: Shakila Thangaratinam, et al.
Published: (2017-04-01)

Seasonal variation of the onset of preeclampsia and eclampsia
by: Ziba Zahiri, et al.
Published: (2007-08-01)

Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity.
by: Gardiner, C, et al.
Published: (2011)

Steroidogenic effects of Taraxacum officinale extract on the levels of steroidogenic enzymes in mouse Leydig cells
by: Hyun Joo Chung, et al.
Published: (2018-11-01)

Excess syncytiotrophoblast microparticle shedding is a feature of pre-eclampsia, but not normotensive intrauterine growth restriction.
by: Goswami, D, et al.
Published: (2004)

Maternal serum copeptin concentrations in early- and late-onset pre-eclampsia
by: Abdullah Tuten, et al.
Published: (2015-08-01)

Usability and Feasibility of PIERS on the Move: An mHealth App for Pre-Eclampsia Triage
by: Lim, Joanne, et al.
Published: (2015-04-01)

Platelet Indicies in Pre-eclampsia and Eclampsia
by: Deepak Donthi, et al.
Published: (2018-04-01)

Aumento no material fibrinoide perivilositário nas placentas de gestações com pré-eclâmpsia Increase in perivillous fibrinoid material in placentas from pregnancies with preeclampsia
by: Diego Agra de Souza, et al.
Published: (2011-02-01)

The early pregnancy placenta foreshadows DNA methylation alterations of solid tumors
by: Akpéli V. Nordor, et al.
Published: (2017-09-01)

Maternal nutritional risk factors for pre-eclampsia incidence: findings from a narrative scoping review
by: Kinshella, M-LW, et al.
Published: (2022)

Placental Pathology in Severe Pre-eclampsia and Eclampsia
by: Kamala Ojha, et al.
Published: (2018-06-01)

Management of Pre-eclampsia and Eclampsia: A Simulation
by: Cynthia Abraham, et al.
Published: (2019-08-01)

Renal biomarkers in pre-eclampsia and their associations with severity of pre-eclampsia
by: Paschalina C Ezechukwu, et al.
Published: (2023-01-01)

Late Onset Atypical Eclampsia: A Case Report
by: Nalini Sharma, et al.
Published: (2019-01-01)

Características obstétricas de mulheres atendidas por pré-eclâmpsia e eclâmpsia = Obstetric characteristics of women treated for pre-eclampsia and eclampsia
by: Ione Cavalcante Lacerda, et al.
Published: (2011-01-01)

Steroidogenic electron-transfer factors and their diseases
by: Walter L. Miller
Published: (2021-09-01)

Proliferation of luteal steroidogenic cells in cattle.
by: Shin Yoshioka, et al.
Published: (2013-01-01)