Development of a Monocyte Activation Test as an Alternative to the Rabbit Pyrogen Test for Mono- and Multi-Component <i>Shigella</i> GMMA-Based Vaccines

Development of a Monocyte Activation Test as an Alternative to the Rabbit Pyrogen Test for Mono- and Multi-Component <i>Shigella</i> GMMA-Based Vaccines

Generalised modules for membrane antigens (GMMA)-based vaccines comprise the outer membrane from genetically modified Gram-negative bacteria containing membrane proteins, phospholipids and lipopolysaccharides. Some lipoproteins and lipopolysaccharides are pyrogens; thus, GMMA-based vaccines are intr...

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Bibliographic Details
Main Authors: Danielle Carson, Sophie Myhill, Elena Palmieri, Francesca Necchi, Sjoerd Rijpkema, Francesca Micoli, Ida Karin Nordgren, Omar Rossi, Caroline Vipond
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Microorganisms
Subjects:
outer membrane vesicle (OMV)
generalised modules for membrane antigens (GMMA)
monocyte activation test (MAT)
reactogenicity
pyrogenicity
Online Access:https://www.mdpi.com/2076-2607/9/7/1375

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https://www.mdpi.com/2076-2607/9/7/1375

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