Aberrant Cerebellar–Cerebral Functional Connectivity in Children and Adolescents With Autism Spectrum Disorder
The cerebellum, which forms widespread functional networks with many areas in the cerebral cortices and subcortical structures, is one of the brain regions most consistently reported to exhibit neuropathological features in patients with autism spectrum disorder (ASD). However, cerebellar functional...
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| Format: | Article |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2018.00454/full |
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| author | Ryuzo Hanaie Ikuko Mohri Ikuko Mohri Ikuko Mohri Kuriko Kagitani-Shimono Kuriko Kagitani-Shimono Kuriko Kagitani-Shimono Masaya Tachibana Masaya Tachibana Masaya Tachibana Junko Matsuzaki Ikuko Hirata Fumiyo Nagatani Yoshiyuki Watanabe Taiichi Katayama Taiichi Katayama Masako Taniike Masako Taniike Masako Taniike |
| author_facet | Ryuzo Hanaie Ikuko Mohri Ikuko Mohri Ikuko Mohri Kuriko Kagitani-Shimono Kuriko Kagitani-Shimono Kuriko Kagitani-Shimono Masaya Tachibana Masaya Tachibana Masaya Tachibana Junko Matsuzaki Ikuko Hirata Fumiyo Nagatani Yoshiyuki Watanabe Taiichi Katayama Taiichi Katayama Masako Taniike Masako Taniike Masako Taniike |
| author_sort | Ryuzo Hanaie |
| collection | DOAJ |
| description | The cerebellum, which forms widespread functional networks with many areas in the cerebral cortices and subcortical structures, is one of the brain regions most consistently reported to exhibit neuropathological features in patients with autism spectrum disorder (ASD). However, cerebellar functional connectivity (FC) studies in patients with ASD have been very sparse. Using resting state functional connectivity (rsFC) analysis, we investigated the FC of the hemispheric/vermal subregions and the dentate nucleus of the cerebellum with the cerebral regions in 36 children and adolescents [16 participants with ASD, 20 typically developing (TD) participants, age: 6–15 years]. Furthermore, an independent larger sample population (42 participants with ASD, 88 TD participants, age: 6–15 years), extracted from the Autism Brain Imaging Data Exchange (ABIDE) II, was included for replication. The ASD group showed significantly increased or decreased FC between “hubs” in the cerebellum and cerebral cortices, when compared with the TD group. Findings of aberrant FCs converged on the posterior hemisphere, right dentate nucleus, and posterior inferior vermis of the cerebellum. Furthermore, these aberrant FCs were found to be related to motor, executive, and socio-communicative functions in children and adolescents with ASD when we examined correlations between FC and behavioral measurements. Results from the original dataset were partially replicated in the independent larger sample population. Our findings suggest that aberrant cerebellar–cerebral FC is associated with motor, socio-communicative, and executive functions in children and adolescents with ASD. These observations improve the current knowledge regarding the neural substrates that underlie the symptoms of ASD. |
| first_indexed | 2024-12-22T02:28:51Z |
| format | Article |
| id | doaj.art-9c9a11baf0fd4df29b2212dbdb17106e |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T02:28:51Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-9c9a11baf0fd4df29b2212dbdb17106e2022-12-21T18:41:56ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612018-11-011210.3389/fnhum.2018.00454410667Aberrant Cerebellar–Cerebral Functional Connectivity in Children and Adolescents With Autism Spectrum DisorderRyuzo Hanaie0Ikuko Mohri1Ikuko Mohri2Ikuko Mohri3Kuriko Kagitani-Shimono4Kuriko Kagitani-Shimono5Kuriko Kagitani-Shimono6Masaya Tachibana7Masaya Tachibana8Masaya Tachibana9Junko Matsuzaki10Ikuko Hirata11Fumiyo Nagatani12Yoshiyuki Watanabe13Taiichi Katayama14Taiichi Katayama15Masako Taniike16Masako Taniike17Masako Taniike18Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Suita, JapanMolecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Suita, JapanDivision of Developmental Neuroscience, United Graduate School of Child Development, Osaka University, Suita, JapanDepartment of Pediatrics, Osaka University Graduate School of Medicine, Suita, JapanMolecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Suita, JapanDivision of Developmental Neuroscience, United Graduate School of Child Development, Osaka University, Suita, JapanDepartment of Pediatrics, Osaka University Graduate School of Medicine, Suita, JapanMolecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Suita, JapanDivision of Developmental Neuroscience, United Graduate School of Child Development, Osaka University, Suita, JapanDepartment of Pediatrics, Osaka University Graduate School of Medicine, Suita, JapanMolecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Suita, JapanDepartment of Pediatrics, Osaka University Graduate School of Medicine, Suita, JapanMolecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Suita, JapanDepartment of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, Suita, JapanMolecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Suita, JapanDivision of Developmental Neuroscience, United Graduate School of Child Development, Osaka University, Suita, JapanMolecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Suita, JapanDivision of Developmental Neuroscience, United Graduate School of Child Development, Osaka University, Suita, JapanDepartment of Pediatrics, Osaka University Graduate School of Medicine, Suita, JapanThe cerebellum, which forms widespread functional networks with many areas in the cerebral cortices and subcortical structures, is one of the brain regions most consistently reported to exhibit neuropathological features in patients with autism spectrum disorder (ASD). However, cerebellar functional connectivity (FC) studies in patients with ASD have been very sparse. Using resting state functional connectivity (rsFC) analysis, we investigated the FC of the hemispheric/vermal subregions and the dentate nucleus of the cerebellum with the cerebral regions in 36 children and adolescents [16 participants with ASD, 20 typically developing (TD) participants, age: 6–15 years]. Furthermore, an independent larger sample population (42 participants with ASD, 88 TD participants, age: 6–15 years), extracted from the Autism Brain Imaging Data Exchange (ABIDE) II, was included for replication. The ASD group showed significantly increased or decreased FC between “hubs” in the cerebellum and cerebral cortices, when compared with the TD group. Findings of aberrant FCs converged on the posterior hemisphere, right dentate nucleus, and posterior inferior vermis of the cerebellum. Furthermore, these aberrant FCs were found to be related to motor, executive, and socio-communicative functions in children and adolescents with ASD when we examined correlations between FC and behavioral measurements. Results from the original dataset were partially replicated in the independent larger sample population. Our findings suggest that aberrant cerebellar–cerebral FC is associated with motor, socio-communicative, and executive functions in children and adolescents with ASD. These observations improve the current knowledge regarding the neural substrates that underlie the symptoms of ASD.https://www.frontiersin.org/article/10.3389/fnhum.2018.00454/fullautism spectrum disordercerebellumcerebral cortexfunctional connectivityresting stateMRI |
| spellingShingle | Ryuzo Hanaie Ikuko Mohri Ikuko Mohri Ikuko Mohri Kuriko Kagitani-Shimono Kuriko Kagitani-Shimono Kuriko Kagitani-Shimono Masaya Tachibana Masaya Tachibana Masaya Tachibana Junko Matsuzaki Ikuko Hirata Fumiyo Nagatani Yoshiyuki Watanabe Taiichi Katayama Taiichi Katayama Masako Taniike Masako Taniike Masako Taniike Aberrant Cerebellar–Cerebral Functional Connectivity in Children and Adolescents With Autism Spectrum Disorder Frontiers in Human Neuroscience autism spectrum disorder cerebellum cerebral cortex functional connectivity resting state MRI |
| title | Aberrant Cerebellar–Cerebral Functional Connectivity in Children and Adolescents With Autism Spectrum Disorder |
| title_full | Aberrant Cerebellar–Cerebral Functional Connectivity in Children and Adolescents With Autism Spectrum Disorder |
| title_fullStr | Aberrant Cerebellar–Cerebral Functional Connectivity in Children and Adolescents With Autism Spectrum Disorder |
| title_full_unstemmed | Aberrant Cerebellar–Cerebral Functional Connectivity in Children and Adolescents With Autism Spectrum Disorder |
| title_short | Aberrant Cerebellar–Cerebral Functional Connectivity in Children and Adolescents With Autism Spectrum Disorder |
| title_sort | aberrant cerebellar cerebral functional connectivity in children and adolescents with autism spectrum disorder |
| topic | autism spectrum disorder cerebellum cerebral cortex functional connectivity resting state MRI |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2018.00454/full |
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