Selective Vulnerability of the Locus Coeruleus Noradrenergic System and its Role in Modulation of Neuroinflammation, Cognition, and Neurodegeneration

Selective Vulnerability of the Locus Coeruleus Noradrenergic System and its Role in Modulation of Neuroinflammation, Cognition, and Neurodegeneration

Locus coeruleus (LC) noradrenergic (NE) neurons supply the main adrenergic input to the forebrain. NE is a dual modulator of cognition and neuroinflammation. NE neurons of the LC are particularly vulnerable to degeneration both with normal aging and in neurodegenerative disorders. Consequences of th...

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Bibliographic Details
Main Authors: Andrew K. Evans, Erwin Defensor, Mehrdad Shamloo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
locus coeruleus
noradrenaline
neuroinflammation
oxidative stress
neurodegeneration
beta-adrenergic
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1030609/full

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