Development of Enthesopathies and Joint Structural Damage in a Murine Model of X-Linked Hypophosphatemia

Development of Enthesopathies and Joint Structural Damage in a Murine Model of X-Linked Hypophosphatemia

X-linked hypophosphatemia (XLH) is characterized by rickets and osteomalacia, caused by inactivating mutations in the Phosphate-regulating endopeptidase homolog X-linked (PHEX) gene. With aging, adult patients develop paradoxical heterotopic calcifications of tendons and ligaments at their insertion...

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Main Authors: Carole-Anne Faraji-Bellée, Axelle Cauliez, Benjamin Salmon, Olivier Fogel, Volha Zhukouskaya, Aurélie Benoit, Thorsten Schinke, Christian Roux, Agnès Linglart, Corinne Miceli-Richard, Catherine Chaussain, Karine Briot, Claire Bardet
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Hyp mouse
natural history
enthesophyte
joint alteration
XLH
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00854/full

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