The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization study
Abstract Background Ankylosing spondylitis (AS) is one of several disorders known as seronegative spinal arthritis (SpA), the origin of which is unknown. Existing epidemiological data show that inflammatory and immunological factors are important in the development of AS. Previous research on the co...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Arthritis Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13075-024-03266-0 |
| _version_ | 1797349795847733248 |
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| author | Yuchang Fei Huan Yu Yulun Wu Shanshan Gong |
| author_facet | Yuchang Fei Huan Yu Yulun Wu Shanshan Gong |
| author_sort | Yuchang Fei |
| collection | DOAJ |
| description | Abstract Background Ankylosing spondylitis (AS) is one of several disorders known as seronegative spinal arthritis (SpA), the origin of which is unknown. Existing epidemiological data show that inflammatory and immunological factors are important in the development of AS. Previous research on the connection between immunological inflammation and AS, however, has shown inconclusive results. Methods To evaluate the causal association between immunological characteristics and AS, a bidirectional, two-sample Mendelian randomization (MR) approach was performed in this study. We investigated the causal connection between 731 immunological feature characteristic cells and AS risk using large, publically available genome-wide association studies. Results After FDR correction, two immunophenotypes were found to be significantly associated with AS risk: CD14 − CD16 + monocyte (OR, 0.669; 95% CI, 0.544 ~ 0.823; P = 1.46 × 10−4; P FDR = 0.043), CD33dim HLA DR + CD11b + (OR, 0.589; 95% CI = 0.446 ~ 0.780; P = 2.12 × 10−4; P FDR = 0.043). AS had statistically significant effects on six immune traits: CD8 on HLA DR + CD8 + T cell (OR, 1.029; 95% CI, 1.015 ~ 1.043; P = 4.46 × 10−5; P FDR = 0.014), IgD on IgD + CD24 + B cell (OR, 0.973; 95% CI, 0.960 ~ 0.987; P = 1.2 × 10−4; P FDR = 0.021), IgD on IgD + CD38 − unswitched memory B cell (OR, 0.962; 95% CI, 0.945 ~ 0.980; P = 3.02 × 10−5; P FDR = 0.014), CD8 + natural killer T %lymphocyte (OR, 0.973; 95% CI, 0.959 ~ 0.987; P = 1.92 × 10−4; P FDR = 0.021), CD8 + natural killer T %T cell (OR, 0.973; 95% CI, 0.959 ~ 0.987; P = 1.65 × 10−4; P FDR = 0.021). Conclusion Our findings extend genetic research into the intimate link between immune cells and AS, which can help guide future clinical and basic research. |
| first_indexed | 2024-03-08T12:35:35Z |
| format | Article |
| id | doaj.art-9c9b9e0b3ca94dc39e4d728f58644313 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-03-08T12:35:35Z |
| publishDate | 2024-01-01 |
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| series | Arthritis Research & Therapy |
| spelling | doaj.art-9c9b9e0b3ca94dc39e4d728f586443132024-01-21T12:29:21ZengBMCArthritis Research & Therapy1478-63622024-01-012611910.1186/s13075-024-03266-0The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization studyYuchang Fei0Huan Yu1Yulun Wu2Shanshan Gong3Department of Integrated Chinese and Western Medicine, The First People’s Hospital of Jiashan, Jiashan Hospital Affiliated of Jiaxing UniversityThe Department of Traditional Chinese Medicine, The First Affiliated Hospital of Ningbo UniversityCenter for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeDepartment of Gastroenterology, The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityAbstract Background Ankylosing spondylitis (AS) is one of several disorders known as seronegative spinal arthritis (SpA), the origin of which is unknown. Existing epidemiological data show that inflammatory and immunological factors are important in the development of AS. Previous research on the connection between immunological inflammation and AS, however, has shown inconclusive results. Methods To evaluate the causal association between immunological characteristics and AS, a bidirectional, two-sample Mendelian randomization (MR) approach was performed in this study. We investigated the causal connection between 731 immunological feature characteristic cells and AS risk using large, publically available genome-wide association studies. Results After FDR correction, two immunophenotypes were found to be significantly associated with AS risk: CD14 − CD16 + monocyte (OR, 0.669; 95% CI, 0.544 ~ 0.823; P = 1.46 × 10−4; P FDR = 0.043), CD33dim HLA DR + CD11b + (OR, 0.589; 95% CI = 0.446 ~ 0.780; P = 2.12 × 10−4; P FDR = 0.043). AS had statistically significant effects on six immune traits: CD8 on HLA DR + CD8 + T cell (OR, 1.029; 95% CI, 1.015 ~ 1.043; P = 4.46 × 10−5; P FDR = 0.014), IgD on IgD + CD24 + B cell (OR, 0.973; 95% CI, 0.960 ~ 0.987; P = 1.2 × 10−4; P FDR = 0.021), IgD on IgD + CD38 − unswitched memory B cell (OR, 0.962; 95% CI, 0.945 ~ 0.980; P = 3.02 × 10−5; P FDR = 0.014), CD8 + natural killer T %lymphocyte (OR, 0.973; 95% CI, 0.959 ~ 0.987; P = 1.92 × 10−4; P FDR = 0.021), CD8 + natural killer T %T cell (OR, 0.973; 95% CI, 0.959 ~ 0.987; P = 1.65 × 10−4; P FDR = 0.021). Conclusion Our findings extend genetic research into the intimate link between immune cells and AS, which can help guide future clinical and basic research.https://doi.org/10.1186/s13075-024-03266-0Immune cellAnkylosing spondylitisCausal inferenceMendelian randomization |
| spellingShingle | Yuchang Fei Huan Yu Yulun Wu Shanshan Gong The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization study Arthritis Research & Therapy Immune cell Ankylosing spondylitis Causal inference Mendelian randomization |
| title | The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization study |
| title_full | The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization study |
| title_fullStr | The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization study |
| title_full_unstemmed | The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization study |
| title_short | The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization study |
| title_sort | causal relationship between immune cells and ankylosing spondylitis a bidirectional mendelian randomization study |
| topic | Immune cell Ankylosing spondylitis Causal inference Mendelian randomization |
| url | https://doi.org/10.1186/s13075-024-03266-0 |
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