Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Abstract Background The prevalence of diabetes mellitus (DM) among patients with chronic kidney disease (CKD) has been increasing in recent years in China. This study aimed to evaluate the association between DM and health-related quality of life (HRQOL) in patients with CKD. Methods In our study, p...

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Main Authors: Li Chen, Jinwei Wang, Xiaoyan Huang, Fang Wang, Wei Liang, Yan He, Yumei Liao, Luxia Zhang, Minghui Zhao, Zuying Xiong, on behalf of the C-STRIDE study group
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Health and Quality of Life Outcomes
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12955-020-01519-5
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author Li Chen
Jinwei Wang
Xiaoyan Huang
Fang Wang
Wei Liang
Yan He
Yumei Liao
Luxia Zhang
Minghui Zhao
Zuying Xiong
on behalf of the C-STRIDE study group
author_facet Li Chen
Jinwei Wang
Xiaoyan Huang
Fang Wang
Wei Liang
Yan He
Yumei Liao
Luxia Zhang
Minghui Zhao
Zuying Xiong
on behalf of the C-STRIDE study group
author_sort Li Chen
collection DOAJ
description Abstract Background The prevalence of diabetes mellitus (DM) among patients with chronic kidney disease (CKD) has been increasing in recent years in China. This study aimed to evaluate the association between DM and health-related quality of life (HRQOL) in patients with CKD. Methods In our study, participants with CKD stage 1 to 4 from 39 centers in China were screened and enrolled. The Kidney Disease Quality of Life (KDQOL™-36) questionnaire was used to assess HRQOL. Participants were divided into a diabetic group and a non-diabetic group. Demographic data, clinical data, and HRQOL scores were compared between the two groups. Multivariable robust regression was used to analyze the factors related to HRQOL in CKD patients. Results A population of 2742 CKD patients was included in this study. CKD patients with DM were older and had lower education level, longer treatment periods and a higher prevalence of cardiovascular disease than CKD patients without DM (P < 0.05). HRQOL scores in the “symptoms and problems”, “effects of kidney disease”, and “SF-12 physical function” dimensions were significantly lower in the diabetic group than the non-diabetic group (86.88 ± 13.76 vs. 90.59 ± 10.75, 84.78 ± 14.86 vs. 87.28 ± 12.45, and 41.40 ± 9.77 vs. 45.40 ± 8.82, respectively, all P < 0.05). DM was negatively correlated with the symptoms and problems (regression coefficient for log transformed [175-score] = 0.010) and the SF-12 physical function dimension (regression coefficient = − 2.18) (all P < 0.05). Conclusion HRQOL of diabetic patients with CKD was worse than that of non-diabetic patients with CKD. DM was an independent and negative factor affecting HRQOL in patients with CKD.
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spelling doaj.art-9c9bbb88e66747169aca0c7a7efd0dd22022-12-22T00:48:37ZengBMCHealth and Quality of Life Outcomes1477-75252020-08-011811810.1186/s12955-020-01519-5Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)Li Chen0Jinwei Wang1Xiaoyan Huang2Fang Wang3Wei Liang4Yan He5Yumei Liao6Luxia Zhang7Minghui Zhao8Zuying Xiong9on behalf of the C-STRIDE study groupRenal Division, Peking University Shenzhen HospitalRenal Division, Department of Medicine, Peking University First HospitalRenal Division, Peking University Shenzhen HospitalRenal Division, Department of Medicine, Peking University First HospitalRenal Division, Peking University Shenzhen HospitalRenal Division, Peking University Shenzhen HospitalRenal Division, Peking University Shenzhen HospitalRenal Division, Department of Medicine, Peking University First HospitalRenal Division, Department of Medicine, Peking University First HospitalRenal Division, Peking University Shenzhen HospitalAbstract Background The prevalence of diabetes mellitus (DM) among patients with chronic kidney disease (CKD) has been increasing in recent years in China. This study aimed to evaluate the association between DM and health-related quality of life (HRQOL) in patients with CKD. Methods In our study, participants with CKD stage 1 to 4 from 39 centers in China were screened and enrolled. The Kidney Disease Quality of Life (KDQOL™-36) questionnaire was used to assess HRQOL. Participants were divided into a diabetic group and a non-diabetic group. Demographic data, clinical data, and HRQOL scores were compared between the two groups. Multivariable robust regression was used to analyze the factors related to HRQOL in CKD patients. Results A population of 2742 CKD patients was included in this study. CKD patients with DM were older and had lower education level, longer treatment periods and a higher prevalence of cardiovascular disease than CKD patients without DM (P < 0.05). HRQOL scores in the “symptoms and problems”, “effects of kidney disease”, and “SF-12 physical function” dimensions were significantly lower in the diabetic group than the non-diabetic group (86.88 ± 13.76 vs. 90.59 ± 10.75, 84.78 ± 14.86 vs. 87.28 ± 12.45, and 41.40 ± 9.77 vs. 45.40 ± 8.82, respectively, all P < 0.05). DM was negatively correlated with the symptoms and problems (regression coefficient for log transformed [175-score] = 0.010) and the SF-12 physical function dimension (regression coefficient = − 2.18) (all P < 0.05). Conclusion HRQOL of diabetic patients with CKD was worse than that of non-diabetic patients with CKD. DM was an independent and negative factor affecting HRQOL in patients with CKD.http://link.springer.com/article/10.1186/s12955-020-01519-5Chronic kidney diseaseDiabetes mellitusEstimated glomerular filtration rateHealth-related quality of life
spellingShingle Li Chen
Jinwei Wang
Xiaoyan Huang
Fang Wang
Wei Liang
Yan He
Yumei Liao
Luxia Zhang
Minghui Zhao
Zuying Xiong
on behalf of the C-STRIDE study group
Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)
Health and Quality of Life Outcomes
Chronic kidney disease
Diabetes mellitus
Estimated glomerular filtration rate
Health-related quality of life
title Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)
title_full Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)
title_fullStr Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)
title_full_unstemmed Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)
title_short Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)
title_sort association between diabetes mellitus and health related quality of life among patients with chronic kidney disease results from the chinese cohort study of chronic kidney disease c stride
topic Chronic kidney disease
Diabetes mellitus
Estimated glomerular filtration rate
Health-related quality of life
url http://link.springer.com/article/10.1186/s12955-020-01519-5
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