Ultrasensitivity in the cofilin signaling module: a mechanism for tuning T cell responses

Ultrasensitivity in the cofilin signaling module: a mechanism for tuning T cell responses

Ultrasensitivity allows filtering weak activating signals and responding emphatically to small changes in stronger stimuli. In the presence of positive feedback loops, ultrasensitivity enables the existence of bistability, which convert graded stimuli into switch-like, sometimes irreversible, respon...

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Bibliographic Details
Main Authors: Rocio eRamirez-Munoz, Patricia eCastro-Sanchez, Pedro eRoda-Navarro
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Immunology
Subjects:
T cell receptor
Ultrasensitivity
bistability
cofilin
Slingshot-1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00059/full

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