Protective effects of resveratrol against fumonisin B1-induced liver toxicity in mice
The aim of this study was to investigate the effects of resveratrol against fumonisin B1 (FB1)-induced liver toxicity, as, to the best of our knowledge, these effects have not been investigated yet, even though the toxic effects and mechanisms of FB1 and the antioxidative effects of resveratrol are...
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| Format: | Article |
| Language: | English |
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Sciendo
2023-06-01
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| Series: | Arhiv za Higijenu Rada i Toksikologiju |
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| Online Access: | https://doi.org/10.2478/aiht-2023-74-3648 |
| _version_ | 1797693222881853440 |
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| author | Yalçın Rıza Kart Asım Özmen Özlem Zeybek Esra |
| author_facet | Yalçın Rıza Kart Asım Özmen Özlem Zeybek Esra |
| author_sort | Yalçın Rıza |
| collection | DOAJ |
| description | The aim of this study was to investigate the effects of resveratrol against fumonisin B1 (FB1)-induced liver toxicity, as, to the best of our knowledge, these effects have not been investigated yet, even though the toxic effects and mechanisms of FB1 and the antioxidative effects of resveratrol are well known. 40 BALB/c mice were divided into control, FB1, resveratrol, and FB1+resveratrol groups. Control received saline for 14 days. The FB1 group received 2.25 mg/kg FB1 every other day for 14 days. The resveratrol group received 10 mg/kg resveratrol for 14 days. The FB1+resveratrol group received 2.25 mg/kg FB1 every other day and 10 mg/kg resveratrol every day for 14 days. All administrations were peritoneal. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total sialic acid (TSA) levels were analysed in serum samples, while total antioxidant status (TAS) and total oxidant status (TOS) were measured in the liver. Additionally, the liver tissue was examined for histopathological changes. AST, ALT, and TSA were significantly higher in the FB1 group than control. Resveratrol countered FB1 effects for all parameters, including TOS and TAS. Liver histology showed FB1-induced hyperaemia, infiltrations, and megalokaryosis in some hepatocytes. No pathological findings were detected in the control, resveratrol, or FB1+resveratrol group. Our findings confirm resveratrol’s protective effect against liver damage and oxidative stress caused by FB1. In addition, they suggest that increased serum TSA levels can be used as a biomarker of FB1-induced hepatotoxicity. |
| first_indexed | 2024-03-12T02:40:26Z |
| format | Article |
| id | doaj.art-9c9d366d2103480fa8acf6eae7d0b283 |
| institution | Directory Open Access Journal |
| issn | 1848-6312 |
| language | English |
| last_indexed | 2024-03-12T02:40:26Z |
| publishDate | 2023-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Arhiv za Higijenu Rada i Toksikologiju |
| spelling | doaj.art-9c9d366d2103480fa8acf6eae7d0b2832023-09-04T07:10:48ZengSciendoArhiv za Higijenu Rada i Toksikologiju1848-63122023-06-0174211511910.2478/aiht-2023-74-3648Protective effects of resveratrol against fumonisin B1-induced liver toxicity in miceYalçın Rıza0Kart Asım1Özmen Özlem2Zeybek Esra31Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Burdur, Turkey1Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Burdur, Turkey2Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pathology, Burdur, Turkey1Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Burdur, TurkeyThe aim of this study was to investigate the effects of resveratrol against fumonisin B1 (FB1)-induced liver toxicity, as, to the best of our knowledge, these effects have not been investigated yet, even though the toxic effects and mechanisms of FB1 and the antioxidative effects of resveratrol are well known. 40 BALB/c mice were divided into control, FB1, resveratrol, and FB1+resveratrol groups. Control received saline for 14 days. The FB1 group received 2.25 mg/kg FB1 every other day for 14 days. The resveratrol group received 10 mg/kg resveratrol for 14 days. The FB1+resveratrol group received 2.25 mg/kg FB1 every other day and 10 mg/kg resveratrol every day for 14 days. All administrations were peritoneal. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total sialic acid (TSA) levels were analysed in serum samples, while total antioxidant status (TAS) and total oxidant status (TOS) were measured in the liver. Additionally, the liver tissue was examined for histopathological changes. AST, ALT, and TSA were significantly higher in the FB1 group than control. Resveratrol countered FB1 effects for all parameters, including TOS and TAS. Liver histology showed FB1-induced hyperaemia, infiltrations, and megalokaryosis in some hepatocytes. No pathological findings were detected in the control, resveratrol, or FB1+resveratrol group. Our findings confirm resveratrol’s protective effect against liver damage and oxidative stress caused by FB1. In addition, they suggest that increased serum TSA levels can be used as a biomarker of FB1-induced hepatotoxicity.https://doi.org/10.2478/aiht-2023-74-3648altastliver damageoxidative stresstotal antioxidant statustotal oxidant statustotal sialic acidaltastoksidacijski stresoštećenje jetreukupni antioksidacijski statusukupni oksidacijski statusukupna sijalinska kiselina |
| spellingShingle | Yalçın Rıza Kart Asım Özmen Özlem Zeybek Esra Protective effects of resveratrol against fumonisin B1-induced liver toxicity in mice Arhiv za Higijenu Rada i Toksikologiju alt ast liver damage oxidative stress total antioxidant status total oxidant status total sialic acid alt ast oksidacijski stres oštećenje jetre ukupni antioksidacijski status ukupni oksidacijski status ukupna sijalinska kiselina |
| title | Protective effects of resveratrol against fumonisin B1-induced liver toxicity in mice |
| title_full | Protective effects of resveratrol against fumonisin B1-induced liver toxicity in mice |
| title_fullStr | Protective effects of resveratrol against fumonisin B1-induced liver toxicity in mice |
| title_full_unstemmed | Protective effects of resveratrol against fumonisin B1-induced liver toxicity in mice |
| title_short | Protective effects of resveratrol against fumonisin B1-induced liver toxicity in mice |
| title_sort | protective effects of resveratrol against fumonisin b1 induced liver toxicity in mice |
| topic | alt ast liver damage oxidative stress total antioxidant status total oxidant status total sialic acid alt ast oksidacijski stres oštećenje jetre ukupni antioksidacijski status ukupni oksidacijski status ukupna sijalinska kiselina |
| url | https://doi.org/10.2478/aiht-2023-74-3648 |
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