Diagnostic value of the creatine kinase-MB/creatine kinase and neutrophil/lymphocyte ratios in acute myocardial infarction
Abstract Objective To investigate the clinical significance of the creatine kinase (CK)-MB/total CK ratio, neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width in acute myocardial infarction (AMI). Methods A retrospective analysis was conducted of 196 AMI cases from our hospital’s...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13019-024-02740-9 |
| _version_ | 1797199205789335552 |
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| author | Yin Liu Xiao-Lei Tang Yong Ni Li-Zhong Duan Feng-Jun Jing |
| author_facet | Yin Liu Xiao-Lei Tang Yong Ni Li-Zhong Duan Feng-Jun Jing |
| author_sort | Yin Liu |
| collection | DOAJ |
| description | Abstract Objective To investigate the clinical significance of the creatine kinase (CK)-MB/total CK ratio, neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width in acute myocardial infarction (AMI). Methods A retrospective analysis was conducted of 196 AMI cases from our hospital’s cardiology department; healthy people were selected over the same period as the control. The two groups’ test indexes were compared through multivariate logistic regression analysis to screen for AMI risk factors; the receiver operating characteristic (ROC) curve was used to evaluate their AMI predictive values. Results The serum CK, CK-MB, CK index, neutrophils and NLR values in the AMI group were significantly higher compared with those in the control group (p < 0.05); however, the levels of serum lymphocytes were significantly lower compared with those in the control group (p < 0.05). Multivariate logistic regression analysis showed that elevated CK-MB and NLR levels were risk factors for AMI (p < 0.05). The ROC curve showed that the area under the curve of the NLR and CK levels were 0.917 and 0.594, respectively. Conclusion The CK index and NLR have a clinical predicting value for AMI and could be used as a clinical auxiliary diagnostic index for the assessment of patients with AMI. |
| first_indexed | 2024-04-24T07:12:04Z |
| format | Article |
| id | doaj.art-9c9f18b995f242f9bfd6b77b77442b35 |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-04-24T07:12:04Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-9c9f18b995f242f9bfd6b77b77442b352024-04-21T11:29:57ZengBMCJournal of Cardiothoracic Surgery1749-80902024-04-011911510.1186/s13019-024-02740-9Diagnostic value of the creatine kinase-MB/creatine kinase and neutrophil/lymphocyte ratios in acute myocardial infarctionYin Liu0Xiao-Lei Tang1Yong Ni2Li-Zhong Duan3Feng-Jun Jing4Clinical laboratory, Traditional Chinese Medicine Hospital of WuhuScience and technology department, The Second Affiliated Hospital of Wannan Medical CollegeClinical laboratory, Traditional Chinese Medicine Hospital of WuhuClinical laboratory, Traditional Chinese Medicine Hospital of WuhuClinical laboratory, Traditional Chinese Medicine Hospital of WuhuAbstract Objective To investigate the clinical significance of the creatine kinase (CK)-MB/total CK ratio, neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width in acute myocardial infarction (AMI). Methods A retrospective analysis was conducted of 196 AMI cases from our hospital’s cardiology department; healthy people were selected over the same period as the control. The two groups’ test indexes were compared through multivariate logistic regression analysis to screen for AMI risk factors; the receiver operating characteristic (ROC) curve was used to evaluate their AMI predictive values. Results The serum CK, CK-MB, CK index, neutrophils and NLR values in the AMI group were significantly higher compared with those in the control group (p < 0.05); however, the levels of serum lymphocytes were significantly lower compared with those in the control group (p < 0.05). Multivariate logistic regression analysis showed that elevated CK-MB and NLR levels were risk factors for AMI (p < 0.05). The ROC curve showed that the area under the curve of the NLR and CK levels were 0.917 and 0.594, respectively. Conclusion The CK index and NLR have a clinical predicting value for AMI and could be used as a clinical auxiliary diagnostic index for the assessment of patients with AMI.https://doi.org/10.1186/s13019-024-02740-9CK-MB/CK rationeutrophil/lymphocyte ratioAcute myocardial infarction |
| spellingShingle | Yin Liu Xiao-Lei Tang Yong Ni Li-Zhong Duan Feng-Jun Jing Diagnostic value of the creatine kinase-MB/creatine kinase and neutrophil/lymphocyte ratios in acute myocardial infarction Journal of Cardiothoracic Surgery CK-MB/CK ratio neutrophil/lymphocyte ratio Acute myocardial infarction |
| title | Diagnostic value of the creatine kinase-MB/creatine kinase and neutrophil/lymphocyte ratios in acute myocardial infarction |
| title_full | Diagnostic value of the creatine kinase-MB/creatine kinase and neutrophil/lymphocyte ratios in acute myocardial infarction |
| title_fullStr | Diagnostic value of the creatine kinase-MB/creatine kinase and neutrophil/lymphocyte ratios in acute myocardial infarction |
| title_full_unstemmed | Diagnostic value of the creatine kinase-MB/creatine kinase and neutrophil/lymphocyte ratios in acute myocardial infarction |
| title_short | Diagnostic value of the creatine kinase-MB/creatine kinase and neutrophil/lymphocyte ratios in acute myocardial infarction |
| title_sort | diagnostic value of the creatine kinase mb creatine kinase and neutrophil lymphocyte ratios in acute myocardial infarction |
| topic | CK-MB/CK ratio neutrophil/lymphocyte ratio Acute myocardial infarction |
| url | https://doi.org/10.1186/s13019-024-02740-9 |
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