Frequency of Esophageal Motility Disorders in Patients with Non-Cardiac Chest Pain
Background and purpose: Non-cardiac chest pain (NCCP) is a common entity with negative effects on quality of life that places a large financial burden on health systems. This study aimed at investigating esophageal motility disorders in patients with NCCP. Materials and methods: This cross-sectional...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2019-10-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-12825-en.html |
| Summary: | Background and purpose: Non-cardiac chest pain (NCCP) is a common entity with negative effects on quality of life that places a large financial burden on health systems. This study aimed at investigating esophageal motility disorders in patients with NCCP.
Materials and methods: This cross-sectional study was conducted in 101 patients with recurrent chest pain without any cardiac disease, attending Ahvaz Imam Khomeini Hospital in a one-year period. Those who had no evidence of gastroesophageal reflux disease (GERD) on upper endoscopy and 24-hr esophageal pH monitoring were referred for conventional esophageal manometry.
Results: From 101 patients, 51 showed endoscopic or pH-metric evidences of GERD. Manometric evaluation was done in 50 patients, including 27 males and 23 females (mean age: 44.2 years, 26-68 years old). Half of the cases (n=25) had abnormal motility disorders, including nonspecific esophageal motility disorder (20%), nutcracker esophagus (10%), diffuse esophageal spasm (8%), hypertensive LES syndrome (8%), and ineffective esophageal motility (4%). Esophageal motility disorders were found to have no significant associations with weight and age (P=0.125 and P=0.285). The rate of esophageal motility disorders were lower in non-smokers (P=0.019).
Conclusion: Esophageal motility disorders and GERD are frequent in patients with NCCP. Further studies are needed to establish a cause-effect relationship. |
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| ISSN: | 1735-9260 1735-9279 |