Bacteriological Profile of Isolates From Urine Samples in Patients of Benign Prostatic Hyperplasia and or Prostatitis Showing Lower Urinary Tract Symptoms
Introduction: The incidence of Benign Prostatic Hyperplasia (BPH) or Prostatitis is increasing considerably worldwide. The Lower Urinary Tract Symptoms (LUTS) due to bacterial aetiology are one of the common factors for the complications among the patients. Aim: To determine the bacterial agent...
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JCDR Research and Publications Private Limited
2016-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/8734/21973_CE(Ra1)_F(AK)_PF1(PJ)_PFA(AK)_PF2(P_ES).pdf |
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| author | PREM PRAKASH MISHRA VED PRAKASH KASHMIR SINGH H MOG SUMIT AGARWAL |
| author_facet | PREM PRAKASH MISHRA VED PRAKASH KASHMIR SINGH H MOG SUMIT AGARWAL |
| author_sort | PREM PRAKASH MISHRA |
| collection | DOAJ |
| description | Introduction: The incidence of Benign Prostatic Hyperplasia
(BPH) or Prostatitis is increasing considerably worldwide. The
Lower Urinary Tract Symptoms (LUTS) due to bacterial aetiology
are one of the common factors for the complications among the
patients.
Aim: To determine the bacterial agents and their antibiotic
sensitivity pattern from the urine samples of patients of BPH or
Prostatitis showing symptoms of LUTS.
Materials and Methods: The cross-sectional study was carried
out in the Department of Microbiology of Rohilkhand Medical
College and Hospital of Northern India from June 2014 to May
2015. A total of 105 urine specimens from patients of BPH and/
or Prostatitis were cultured by a semi-quantitative method.
The isolated bacteria were identified by colony morphology,
Gram’s staining, motility and biochemical tests. Antibiotic
sensitivity was done according to the CLSI 2007 guidelines
by disc diffusion method. Data was analysed by SPSS and
Microsoft office 2007. Proportions and percentages were used
as statistical measures.
Results: The urine cultures from patients with BPH and or chronic
Prostatitis, showed n=66/105 (62.85%) culture positivity. Out of
66 isolates the frequency was in following order Escherichia coli
21/66 (31.81%), Klebsiella spp 19/66 (28.78%), Staphylococcus
aureus 11/66 (16.66%), Pseudomonas aeruginosa (10.60%),
Proteus spp, Enterococcus spp, Acinetobacter spp and
Citrobacter spp. The most susceptible 1st, 2nd and 3rd line
antibiotics for Gram negative isolates were ampicillin, amikacin
and tigecycline respectively. Amongst the Gram positive isolates,
the susceptible 1st, 2nd and 3rd line antibiotics were cefoxitin,
vancomycin, teicoplanin and linezolid. Multidrug resistance was
seen in Escherichia coli (n=6), Klebsiella spp (n=7), Pseudomonas
aeruginosa (n=4) and Staphylococcus aureus (n=3).
Conclusion: Based on the above findings we can say that
accurate aetiology of the LUTS among the patients of BPH
and/or Prostatitis is warranted to initiate the therapeutic
management. Based on our study we state that the prime
pathogens are E.coli, Klebsiella among Gram negative isolates
and S. aureus among Gram positive. The most sensitive drugs
are aminoglycosides, tetracyclines and carbepenems for Gram
neagtive isolates and oxazolidinones and glycopeptides among
Gram positive isolates. |
| first_indexed | 2024-12-14T22:09:09Z |
| format | Article |
| id | doaj.art-9ca044ade19440d884b6110b0022b25d |
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| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T22:09:09Z |
| publishDate | 2016-10-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-9ca044ade19440d884b6110b0022b25d2022-12-21T22:45:48ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-10-011010DC16DC1810.7860/JCDR/2016/21973.8734Bacteriological Profile of Isolates From Urine Samples in Patients of Benign Prostatic Hyperplasia and or Prostatitis Showing Lower Urinary Tract SymptomsPREM PRAKASH MISHRA0VED PRAKASH1KASHMIR SINGH2H MOG3SUMIT AGARWAL4Assistant Professor, Department of Microbiology, RMCH, Bareilly, UP, India.Professor, Department of Microbiology, RMCH, Bareilly, UP, India.Professor, Department of Surgery, RMCH, Bareilly, UP, India.PG Student, Department of Microbiology, RMCH, Bareilly, UP, India.PG Student, Department of Microbiology, RMCH, Bareilly, UP, India.Introduction: The incidence of Benign Prostatic Hyperplasia (BPH) or Prostatitis is increasing considerably worldwide. The Lower Urinary Tract Symptoms (LUTS) due to bacterial aetiology are one of the common factors for the complications among the patients. Aim: To determine the bacterial agents and their antibiotic sensitivity pattern from the urine samples of patients of BPH or Prostatitis showing symptoms of LUTS. Materials and Methods: The cross-sectional study was carried out in the Department of Microbiology of Rohilkhand Medical College and Hospital of Northern India from June 2014 to May 2015. A total of 105 urine specimens from patients of BPH and/ or Prostatitis were cultured by a semi-quantitative method. The isolated bacteria were identified by colony morphology, Gram’s staining, motility and biochemical tests. Antibiotic sensitivity was done according to the CLSI 2007 guidelines by disc diffusion method. Data was analysed by SPSS and Microsoft office 2007. Proportions and percentages were used as statistical measures. Results: The urine cultures from patients with BPH and or chronic Prostatitis, showed n=66/105 (62.85%) culture positivity. Out of 66 isolates the frequency was in following order Escherichia coli 21/66 (31.81%), Klebsiella spp 19/66 (28.78%), Staphylococcus aureus 11/66 (16.66%), Pseudomonas aeruginosa (10.60%), Proteus spp, Enterococcus spp, Acinetobacter spp and Citrobacter spp. The most susceptible 1st, 2nd and 3rd line antibiotics for Gram negative isolates were ampicillin, amikacin and tigecycline respectively. Amongst the Gram positive isolates, the susceptible 1st, 2nd and 3rd line antibiotics were cefoxitin, vancomycin, teicoplanin and linezolid. Multidrug resistance was seen in Escherichia coli (n=6), Klebsiella spp (n=7), Pseudomonas aeruginosa (n=4) and Staphylococcus aureus (n=3). Conclusion: Based on the above findings we can say that accurate aetiology of the LUTS among the patients of BPH and/or Prostatitis is warranted to initiate the therapeutic management. Based on our study we state that the prime pathogens are E.coli, Klebsiella among Gram negative isolates and S. aureus among Gram positive. The most sensitive drugs are aminoglycosides, tetracyclines and carbepenems for Gram neagtive isolates and oxazolidinones and glycopeptides among Gram positive isolates.https://jcdr.net/articles/PDF/8734/21973_CE(Ra1)_F(AK)_PF1(PJ)_PFA(AK)_PF2(P_ES).pdfbacteriaprostateurological disorders |
| spellingShingle | PREM PRAKASH MISHRA VED PRAKASH KASHMIR SINGH H MOG SUMIT AGARWAL Bacteriological Profile of Isolates From Urine Samples in Patients of Benign Prostatic Hyperplasia and or Prostatitis Showing Lower Urinary Tract Symptoms Journal of Clinical and Diagnostic Research bacteria prostate urological disorders |
| title | Bacteriological Profile of Isolates From Urine Samples in Patients of Benign Prostatic Hyperplasia and or Prostatitis Showing Lower Urinary Tract Symptoms |
| title_full | Bacteriological Profile of Isolates From Urine Samples in Patients of Benign Prostatic Hyperplasia and or Prostatitis Showing Lower Urinary Tract Symptoms |
| title_fullStr | Bacteriological Profile of Isolates From Urine Samples in Patients of Benign Prostatic Hyperplasia and or Prostatitis Showing Lower Urinary Tract Symptoms |
| title_full_unstemmed | Bacteriological Profile of Isolates From Urine Samples in Patients of Benign Prostatic Hyperplasia and or Prostatitis Showing Lower Urinary Tract Symptoms |
| title_short | Bacteriological Profile of Isolates From Urine Samples in Patients of Benign Prostatic Hyperplasia and or Prostatitis Showing Lower Urinary Tract Symptoms |
| title_sort | bacteriological profile of isolates from urine samples in patients of benign prostatic hyperplasia and or prostatitis showing lower urinary tract symptoms |
| topic | bacteria prostate urological disorders |
| url | https://jcdr.net/articles/PDF/8734/21973_CE(Ra1)_F(AK)_PF1(PJ)_PFA(AK)_PF2(P_ES).pdf |
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