Low VHL mRNA expression is associated with more aggressive tumor features of papillary thyroid carcinoma.
Alterations of the von Hippel-Lindau (VHL) tumor suppressor gene can cause different hereditary tumors associated with VHL syndrome, but the potential role of the VHL gene in papillary thyroid carcinoma (PTC) has not been characterized. This study set out to investigate the relationship of VHL expre...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4260854?pdf=render |
| _version_ | 1828432974902722560 |
|---|---|
| author | Boban Stanojevic Vladimir Saenko Lidija Todorovic Nina Petrovic Dragan Nikolic Vladan Zivaljevic Ivan Paunovic Masahiro Nakashima Shunichi Yamashita Radan Dzodic |
| author_facet | Boban Stanojevic Vladimir Saenko Lidija Todorovic Nina Petrovic Dragan Nikolic Vladan Zivaljevic Ivan Paunovic Masahiro Nakashima Shunichi Yamashita Radan Dzodic |
| author_sort | Boban Stanojevic |
| collection | DOAJ |
| description | Alterations of the von Hippel-Lindau (VHL) tumor suppressor gene can cause different hereditary tumors associated with VHL syndrome, but the potential role of the VHL gene in papillary thyroid carcinoma (PTC) has not been characterized. This study set out to investigate the relationship of VHL expression level with clinicopathological features of PTC in an ethnically and geographically homogenous group of 264 patients from Serbia, for the first time. Multivariate logistic regression analysis showed a strong correlation between low level of VHL expression and advanced clinical stage (OR = 5.78, 95% CI 3.17-10.53, P<0.0001), classical papillary morphology of the tumor (OR = 2.92, 95% CI 1.33-6.44, P = 0.008) and multifocality (OR = 1.96, 95% CI 1.06-3.62, P = 0.031). In disease-free survival analysis, low VHL expression had marginal significance (P = 0.0502 by the log-rank test) but did not appear to be an independent predictor of the risk for chance of faster recurrence in a proportion hazards model. No somatic mutations or evidence of VHL downregulation via promoter hypermethylation in PTC were found. The results indicate that the decrease of VHL expression associates with tumor progression but the mechanism of downregulation remains to be elucidated. |
| first_indexed | 2024-12-10T18:28:42Z |
| format | Article |
| id | doaj.art-9ca08e59431248f5b516e7e37f312066 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T18:28:42Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9ca08e59431248f5b516e7e37f3120662022-12-22T01:38:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11451110.1371/journal.pone.0114511Low VHL mRNA expression is associated with more aggressive tumor features of papillary thyroid carcinoma.Boban StanojevicVladimir SaenkoLidija TodorovicNina PetrovicDragan NikolicVladan ZivaljevicIvan PaunovicMasahiro NakashimaShunichi YamashitaRadan DzodicAlterations of the von Hippel-Lindau (VHL) tumor suppressor gene can cause different hereditary tumors associated with VHL syndrome, but the potential role of the VHL gene in papillary thyroid carcinoma (PTC) has not been characterized. This study set out to investigate the relationship of VHL expression level with clinicopathological features of PTC in an ethnically and geographically homogenous group of 264 patients from Serbia, for the first time. Multivariate logistic regression analysis showed a strong correlation between low level of VHL expression and advanced clinical stage (OR = 5.78, 95% CI 3.17-10.53, P<0.0001), classical papillary morphology of the tumor (OR = 2.92, 95% CI 1.33-6.44, P = 0.008) and multifocality (OR = 1.96, 95% CI 1.06-3.62, P = 0.031). In disease-free survival analysis, low VHL expression had marginal significance (P = 0.0502 by the log-rank test) but did not appear to be an independent predictor of the risk for chance of faster recurrence in a proportion hazards model. No somatic mutations or evidence of VHL downregulation via promoter hypermethylation in PTC were found. The results indicate that the decrease of VHL expression associates with tumor progression but the mechanism of downregulation remains to be elucidated.http://europepmc.org/articles/PMC4260854?pdf=render |
| spellingShingle | Boban Stanojevic Vladimir Saenko Lidija Todorovic Nina Petrovic Dragan Nikolic Vladan Zivaljevic Ivan Paunovic Masahiro Nakashima Shunichi Yamashita Radan Dzodic Low VHL mRNA expression is associated with more aggressive tumor features of papillary thyroid carcinoma. PLoS ONE |
| title | Low VHL mRNA expression is associated with more aggressive tumor features of papillary thyroid carcinoma. |
| title_full | Low VHL mRNA expression is associated with more aggressive tumor features of papillary thyroid carcinoma. |
| title_fullStr | Low VHL mRNA expression is associated with more aggressive tumor features of papillary thyroid carcinoma. |
| title_full_unstemmed | Low VHL mRNA expression is associated with more aggressive tumor features of papillary thyroid carcinoma. |
| title_short | Low VHL mRNA expression is associated with more aggressive tumor features of papillary thyroid carcinoma. |
| title_sort | low vhl mrna expression is associated with more aggressive tumor features of papillary thyroid carcinoma |
| url | http://europepmc.org/articles/PMC4260854?pdf=render |
| work_keys_str_mv | AT bobanstanojevic lowvhlmrnaexpressionisassociatedwithmoreaggressivetumorfeaturesofpapillarythyroidcarcinoma AT vladimirsaenko lowvhlmrnaexpressionisassociatedwithmoreaggressivetumorfeaturesofpapillarythyroidcarcinoma AT lidijatodorovic lowvhlmrnaexpressionisassociatedwithmoreaggressivetumorfeaturesofpapillarythyroidcarcinoma AT ninapetrovic lowvhlmrnaexpressionisassociatedwithmoreaggressivetumorfeaturesofpapillarythyroidcarcinoma AT dragannikolic lowvhlmrnaexpressionisassociatedwithmoreaggressivetumorfeaturesofpapillarythyroidcarcinoma AT vladanzivaljevic lowvhlmrnaexpressionisassociatedwithmoreaggressivetumorfeaturesofpapillarythyroidcarcinoma AT ivanpaunovic lowvhlmrnaexpressionisassociatedwithmoreaggressivetumorfeaturesofpapillarythyroidcarcinoma AT masahironakashima lowvhlmrnaexpressionisassociatedwithmoreaggressivetumorfeaturesofpapillarythyroidcarcinoma AT shunichiyamashita lowvhlmrnaexpressionisassociatedwithmoreaggressivetumorfeaturesofpapillarythyroidcarcinoma AT radandzodic lowvhlmrnaexpressionisassociatedwithmoreaggressivetumorfeaturesofpapillarythyroidcarcinoma |