Novel method to quantify peptidylarginine deiminase activity shows distinct citrullination patterns in rheumatoid and juvenile idiopathic arthritis

Novel method to quantify peptidylarginine deiminase activity shows distinct citrullination patterns in rheumatoid and juvenile idiopathic arthritis

IntroductionPeptidylarginine deiminases (PADs) mediate citrullination, an irreversible posttranslational modification that converts arginine to citrulline residues in proteins. Rheumatoid arthritis (RA) is characterized by unique autoantibodies that recognize citrullinated peptides, which are highly...

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Bibliográfalaš dieđut
Váldodahkkit: Karen Yu, Luna Dillemans, Mieke Gouwy, Helena Bessa, Mieke Metzemaekers, Erik Martens, Patrick Matthys, Xavier Bossuyt, Patrick Verschueren, Carine Wouters, Lien De Somer, Paul Proost
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Frontiers Media S.A. 2023-01-01
Ráidu:Frontiers in Immunology
Fáttát:
citrullination
inflammation
joint inflammation
peptidylarginine deiminase
autoimmunity
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111465/full

Interneahtta

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111465/full

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