Characterization in Effective Stimulation on the Magnitude, Gating, Frequency Dependence, and Hysteresis of <i>I</i><sub>Na</sub> Exerted by Picaridin (or Icaridin), a Known Insect Repellent

Characterization in Effective Stimulation on the Magnitude, Gating, Frequency Dependence, and Hysteresis of <i>I</i><sub>Na</sub> Exerted by Picaridin (or Icaridin), a Known Insect Repellent

Picaridin (icaridin), a member of the piperidine chemical family, is a broad-spectrum arthropod repellent. Its actions have been largely thought to be due to its interaction with odorant receptor proteins. However, to our knowledge, to what extent the presence of picaridin can modify the magnitude,...

Full description

Bibliographic Details
Main Authors:	Ai-Li Shiau, Chih-Szu Liao, Chi-Wen Tu, Sheng-Nan Wu, Hsin-Yen Cho, Meng-Cheng Yu
Format:	Article
Language:	English
Published:	MDPI AG 2022-08-01
Series:	International Journal of Molecular Sciences
Subjects:	picaridin (icaridin) voltage-gated Na<sup>+</sup> current late Na<sup>+</sup> current transient Na<sup>+</sup> current persistent Na<sup>+</sup> current resurgent Na<sup>+</sup> current
Online Access:	https://www.mdpi.com/1422-0067/23/17/9696

Similar Items

Effective Modulation by Lacosamide on Cumulative Inhibition of <i>I</i><sub>Na</sub> during High-Frequency Stimulation and Recovery of <i>I</i><sub>Na</sub> Block during Conditioning Pulse Train
by: Po-Ming Wu, et al.
Published: (2022-10-01)

Characterization in Potent Modulation on Voltage-Gated Na<sup>+</sup> Current Exerted by Deltamethrin, a Pyrethroid Insecticide
by: Mao-Hsun Lin, et al.
Published: (2022-11-01)

Characterization of Stimulatory Action on Voltage-Gated Na<sup>+</sup> Currents Caused by Omecamtiv Mecarbil, Known to Be a Myosin Activator
by: Chih-Yu Ting, et al.
Published: (2023-05-01)

Inhibition of Voltage-Gated Na<sup>+</sup> Currents Exerted by KB-R7943 (2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea), an Inhibitor of Na<sup>+</sup>-Ca<sup>2+</sup> Exchanging Process
by: Sheng-Nan Wu, et al.
Published: (2023-01-01)

Effectiveness of Columbianadin, a Bioactive Coumarin Derivative, in Perturbing Transient and Persistent <i>I</i><sub>Na</sub>
by: Wei-Ting Chang, et al.
Published: (2021-01-01)

The Evidence for Effective Inhibition of <i>I</i><sub>Na</sub> Produced by Mirogabalin ((1R,5S,6S)-6-(aminomethyl)-3-ethyl-bicyclo [3.2.0] hept-3-ene-6-acetic acid), a Known Blocker of Ca<sub>V</sub> Channels
by: Chao-Liang Wu, et al.
Published: (2022-03-01)

Characterization of Direct Perturbations on Voltage-Gated Sodium Current by Esaxerenone, a Nonsteroidal Mineralocorticoid Receptor Blocker
by: Wei-Ting Chang, et al.
Published: (2021-05-01)

Zingerone Modulates Neuronal Voltage-Gated Na<sup>+</sup> and L-Type Ca<sup>2+</sup> Currents
by: Ming-Chi Lai, et al.
Published: (2022-03-01)

Activation of Voltage-Gated Na<sup>+</sup> Current by GV-58, a Known Activator of Ca<sub>V</sub> Channels
by: Hsin-Yen Cho, et al.
Published: (2022-03-01)

Effective Perturbations by Phenobarbital on <i>I</i><sub>Na</sub>, <i>I</i><sub>K(erg)</sub>, <i>I</i><sub>K(M)</sub> and <i>I</i><sub>K(DR)</sub> during Pulse Train Stimulation in Neuroblastoma Neuro-2a Cells
by: Po-Ming Wu, et al.
Published: (2022-08-01)

Effective Accentuation of Voltage-Gated Sodium Current Caused by Apocynin (4′-Hydroxy-3′-methoxyacetophenone), a Known NADPH-Oxidase Inhibitor
by: Tzu-Hsien Chuang, et al.
Published: (2021-09-01)

The Modulation of Ubiquinone, a Lipid Antioxidant, on Neuronal Voltage-Gated Sodium Current
by: Te-Yu Hung, et al.
Published: (2022-08-01)

Characterization in Inhibitory Effectiveness of Carbamazepine in Voltage-Gated Na<sup>+</sup> and Erg-Mediated K<sup>+</sup> Currents in a Mouse Neural Crest-Derived (Neuro-2a) Cell Line
by: Po-Ming Wu, et al.
Published: (2022-07-01)

Effects of Sesamin, the Major Furofuran Lignan of Sesame Oil, on the Amplitude and Gating of Voltage-Gated Na<sup>+</sup> and K<sup>+</sup> Currents
by: Ping-Chung Kuo, et al.
Published: (2020-07-01)

Effective Perturbations by Small-Molecule Modulators on Voltage-Dependent Hysteresis of Transmembrane Ionic Currents
by: Sheng-Nan Wu, et al.
Published: (2022-08-01)

Glutamate-Evoked Ca<sup>2+</sup> Responses in the Rat Suprachiasmatic Nucleus: Involvement of Na<sup>+</sup>/K<sup>+</sup>-ATPase and Na<sup>+</sup>/Ca<sup>2+</sup>-Exchanger
by: Pi-Cheng Cheng, et al.
Published: (2023-03-01)

Deficiency of Thyroid Hormone Reduces Voltage-Gated Na<sup>+</sup> Currents as Well as Expression of Na<sup>+</sup>/K<sup>+</sup>-ATPase in the Mouse Hippocampus
by: Sivaraj Mohana Sundaram, et al.
Published: (2022-04-01)

Calcium Signaling Silencing in Atrial Fibrillation: Implications for Atrial Sodium Homeostasis
by: Aaron D. Kaplan, et al.
Published: (2021-09-01)

The Evidence for Sparsentan-Mediated Inhibition of <i>I</i><sub>Na</sub> and <i>I</i><sub>K(erg)</sub>: Possibly Unlinked to Its Antagonism of Angiotensin II or Endothelin Type a Receptor
by: Tzu-Hsien Chuang, et al.
Published: (2021-12-01)

Na<sup>+</sup>,K<sup>+</sup>-ATPase with Disrupted Na<sup>+</sup> Binding Sites I and III Binds Na<sup>+</sup> with Increased Affinity at Site II and Undergoes Na<sup>+</sup>-Activated Phosphorylation with ATP
by: Hang N. Nielsen, et al.
Published: (2024-01-01)

Ranolazine: An Old Drug with Emerging Potential; Lessons from Pre-Clinical and Clinical Investigations for Possible Repositioning
by: Sarah Rouhana, et al.
Published: (2021-12-01)

Overexpression of an Inositol Phosphorylceramide Glucuronosyltransferase Gene <i>IbIPUT1</i> Inhibits Na<sup>+</sup> Uptake in Sweet Potato Roots
by: Chong Liu, et al.
Published: (2022-06-01)

Inhibitory Effectiveness of Gomisin A, a Dibenzocyclooctadiene Lignan Isolated from <i>Schizandra chinensis</i>, on the Amplitude and Gating of Voltage-Gated Na<sup>+</sup> Current
by: Wei-Ting Chang, et al.
Published: (2020-11-01)

The Novel Direct Modulatory Effects of Perampanel, an Antagonist of AMPA Receptors, on Voltage-Gated Sodium and M-type Potassium Currents
by: Ming-Chi Lai, et al.
Published: (2019-10-01)

The Integrated Effects of Brivaracetam, a Selective Analog of Levetiracetam, on Ionic Currents and Neuronal Excitability
by: Te-Yu Hung, et al.
Published: (2021-04-01)

Cannabidiol Modulates M-Type K<sup>+</sup> and Hyperpolarization-Activated Cation Currents
by: Yen-Chin Liu, et al.
Published: (2023-09-01)

Na<sup>+</sup> Binding and Transport: Insights from Light-Driven Na<sup>+</sup>-Pumping Rhodopsin
by: Qifan Yang, et al.
Published: (2023-10-01)

Comprehensive Evaluation of Morpho-Physiological and Ionic Traits in Wheat (<i>Triticum aestivum</i> L.) Genotypes under Salinity Stress
by: Shiksha Chaurasia, et al.
Published: (2022-10-01)

Higher Na<sup>+</sup>-Ca<sup>2+</sup> Exchanger Function and Triggered Activity Contribute to Male Predisposition to Atrial Fibrillation
by: Simon Thibault, et al.
Published: (2022-09-01)

Late Na<sup>+</sup> Current Is [Ca<sup>2+</sup>]<sub>i</sub>-Dependent in Canine Ventricular Myocytes
by: Dénes Kiss, et al.
Published: (2021-11-01)

Mitochondria-Rich Cells: A Novel Type of Concealed Cell in the Small Intestine of Chinese Soft-Shelled Turtles (<i>Pelodiscus Sinensis</i>)
by: Waseem Ali Vistro, et al.
Published: (2019-09-01)

High Efficacy by GAL-021: A Known Intravenous Peripheral Chemoreceptor Modulator that Suppresses BK<sub>Ca</sub>-Channel Activity and Inhibits <i>I</i><sub>K(M)</sub> or <i>I</i><sub>h</sub>
by: Te-Ling Lu, et al.
Published: (2020-01-01)

The Effectiveness of Isoplumbagin and Plumbagin in Regulating Amplitude, Gating Kinetics, and Voltage-Dependent Hysteresis of <i>erg</i>-mediated K<sup>+</sup> Currents
by: Linyi Chen, et al.
Published: (2022-03-01)

Functional Characterization of Two Novel Mutations in <i>SCN5A</i> Associated with Brugada Syndrome Identified in Italian Patients
by: Cristina Balla, et al.
Published: (2021-06-01)

Exogenous Application of Indol-3-Acetic Acid and Salicylic Acid Improves Tolerance to Salt Stress in Olive Plantlets (<i>Olea europaea</i> L. Cultivar Picual) in Growth Chamber Environments
by: María del Pilar Cordovilla, et al.
Published: (2023-02-01)

How Do Gene Expression Patterns Change in Response to Osmotic Stresses in Kuruma Shrimp (<i>Marsupenaeus japonicus</i>)?
by: Yuquan Li, et al.
Published: (2022-12-01)

The effect of saponins from <it>Ampelozizyphus amazonicus</it> Ducke on the renal Na<sup>+</sup> pumps’ activities and urinary excretion of natriuretic peptides
by: Diniz Lúcio Ricardo, et al.
Published: (2012-04-01)

Sodium Energetic Cycle in the Natronophilic Bacterium <i>Thioalkalivibrio versutus</i>
by: Maria S. Muntyan, et al.
Published: (2022-02-01)

Comparative Na<sup>+</sup> and K<sup>+</sup> Profiling Reveals Microbial Community Assembly of Alfalfa Silage in Different Saline-Alkali Soils
by: Shengnan Li, et al.
Published: (2023-09-01)

Effect of NaCl on Morphophysiological and Biochemical Responses in <i>Gossypium hirsutum</i> L.
by: Sabahat Shaheen, et al.
Published: (2023-03-01)