Targeting Heme Oxygenase-1 in Cardiovascular and Kidney Disease
Heme oxygenase (HO) plays an important role in the cardiovascular system. It is involved in many physiological and pathophysiological processes in all organs of the cardiovascular system. From the regulation of blood pressure and blood flow to the adaptive response to end-organ injury, HO plays a cr...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-06-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/8/6/181 |
| _version_ | 1797707406401077248 |
|---|---|
| author | Heather A. Drummond Zachary L. Mitchell Nader G. Abraham David E. Stec |
| author_facet | Heather A. Drummond Zachary L. Mitchell Nader G. Abraham David E. Stec |
| author_sort | Heather A. Drummond |
| collection | DOAJ |
| description | Heme oxygenase (HO) plays an important role in the cardiovascular system. It is involved in many physiological and pathophysiological processes in all organs of the cardiovascular system. From the regulation of blood pressure and blood flow to the adaptive response to end-organ injury, HO plays a critical role in the ability of the cardiovascular system to respond and adapt to changes in homeostasis. There have been great advances in our understanding of the role of HO in the regulation of blood pressure and target organ injury in the last decade. Results from these studies demonstrate that targeting of the HO system could provide novel therapeutic opportunities for the treatment of several cardiovascular and renal diseases. The goal of this review is to highlight the important role of HO in the regulation of cardiovascular and renal function and protection from disease and to highlight areas in which targeting of the HO system needs to be translated to help benefit patient populations. |
| first_indexed | 2024-03-12T06:06:55Z |
| format | Article |
| id | doaj.art-9ca17c12159e4c96bad3762fbe755e03 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T06:06:55Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-9ca17c12159e4c96bad3762fbe755e032023-09-03T03:34:39ZengMDPI AGAntioxidants2076-39212019-06-018618110.3390/antiox8060181antiox8060181Targeting Heme Oxygenase-1 in Cardiovascular and Kidney DiseaseHeather A. Drummond0Zachary L. Mitchell1Nader G. Abraham2David E. Stec3Department of Physiology and Biophysics, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MI 39216, USADepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MI 39216, USADepartments of Medicine and Pharmacology, New York Medical College, Vahalla, NY 10595, USADepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MI 39216, USAHeme oxygenase (HO) plays an important role in the cardiovascular system. It is involved in many physiological and pathophysiological processes in all organs of the cardiovascular system. From the regulation of blood pressure and blood flow to the adaptive response to end-organ injury, HO plays a critical role in the ability of the cardiovascular system to respond and adapt to changes in homeostasis. There have been great advances in our understanding of the role of HO in the regulation of blood pressure and target organ injury in the last decade. Results from these studies demonstrate that targeting of the HO system could provide novel therapeutic opportunities for the treatment of several cardiovascular and renal diseases. The goal of this review is to highlight the important role of HO in the regulation of cardiovascular and renal function and protection from disease and to highlight areas in which targeting of the HO system needs to be translated to help benefit patient populations.https://www.mdpi.com/2076-3921/8/6/181bilirubincarbon monoxidehypertensionkidney injuryblood pressure |
| spellingShingle | Heather A. Drummond Zachary L. Mitchell Nader G. Abraham David E. Stec Targeting Heme Oxygenase-1 in Cardiovascular and Kidney Disease Antioxidants bilirubin carbon monoxide hypertension kidney injury blood pressure |
| title | Targeting Heme Oxygenase-1 in Cardiovascular and Kidney Disease |
| title_full | Targeting Heme Oxygenase-1 in Cardiovascular and Kidney Disease |
| title_fullStr | Targeting Heme Oxygenase-1 in Cardiovascular and Kidney Disease |
| title_full_unstemmed | Targeting Heme Oxygenase-1 in Cardiovascular and Kidney Disease |
| title_short | Targeting Heme Oxygenase-1 in Cardiovascular and Kidney Disease |
| title_sort | targeting heme oxygenase 1 in cardiovascular and kidney disease |
| topic | bilirubin carbon monoxide hypertension kidney injury blood pressure |
| url | https://www.mdpi.com/2076-3921/8/6/181 |
| work_keys_str_mv | AT heatheradrummond targetinghemeoxygenase1incardiovascularandkidneydisease AT zacharylmitchell targetinghemeoxygenase1incardiovascularandkidneydisease AT nadergabraham targetinghemeoxygenase1incardiovascularandkidneydisease AT davidestec targetinghemeoxygenase1incardiovascularandkidneydisease |