Recent trends in anti-cancer activities of terrestrial plants-based polysaccharides: A review
Cancer has become one of the major diseases threatening human health. Conventional therapies have great adverse effects and are prone to drug resistance, and novel therapies are expensive and cause a heavy burden to patients. Plant polysaccharide has become a research hotspot in the field of anti-tu...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893923000622 |
| _version_ | 1797383671062200320 |
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| author | Hao Ju Chong Yu Xian-Dong Zhang Wei Liu Yan-Chao Wu Pi-Xian Gong Hai-Huang Li Yang Liu Hui-Jing Li |
| author_facet | Hao Ju Chong Yu Xian-Dong Zhang Wei Liu Yan-Chao Wu Pi-Xian Gong Hai-Huang Li Yang Liu Hui-Jing Li |
| author_sort | Hao Ju |
| collection | DOAJ |
| description | Cancer has become one of the major diseases threatening human health. Conventional therapies have great adverse effects and are prone to drug resistance, and novel therapies are expensive and cause a heavy burden to patients. Plant polysaccharide has become a research hotspot in the field of anti-tumor functional foods and pharmaceuticals due to its advantages of high efficiency and low toxicity. Studies have shown that plant polysaccharides have little toxic and side effects and are characterized by multiple perspectives and mechanisms, preventing the emergence of drug resistance. Its anti-cancer molecular mechanisms mainly include inhibiting tumor proliferation and tumor apoptosis, inducing autophagy, effecting cell cycle, inhibiting tumor angiogenesis, regulating epithelial-mesenchymal transition, tumor oxidative stress and immune regulation. Compared with existing cancer drugs, plant polysaccharides have become one of the research hotspots in the field of anti-tumor due to their safety and efficiency. In this context, this review searched the anti-cancer literature on plant polysaccharides published from 2020 to 2022. By comparing the advantages and disadvantages of current and traditional cancer treatment methods, the feasibility of plant polysaccharides as effective natural drugs for the treatment and prevention of cancer was further explored. |
| first_indexed | 2024-03-08T21:24:25Z |
| format | Article |
| id | doaj.art-9ca256019199407a8332fed732328d4f |
| institution | Directory Open Access Journal |
| issn | 2666-8939 |
| language | English |
| last_indexed | 2024-03-08T21:24:25Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj.art-9ca256019199407a8332fed732328d4f2023-12-21T07:37:37ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392023-12-016100341Recent trends in anti-cancer activities of terrestrial plants-based polysaccharides: A reviewHao Ju0Chong Yu1Xian-Dong Zhang2Wei Liu3Yan-Chao Wu4Pi-Xian Gong5Hai-Huang Li6Yang Liu7Hui-Jing Li8Weihai Marine Organism & Medical Technology Research Institute, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150006, P. R. ChinaWeihai Marine Organism & Medical Technology Research Institute, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150006, P. R. ChinaSichuan Mass Spectrometry Biotechnology Co., Ltd, Chengdu 611130, P. R. ChinaWeihai Marine Organism & Medical Technology Research Institute, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150006, P. R. ChinaWeihai Marine Organism & Medical Technology Research Institute, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150006, P. R. China; Sichuan Mass Spectrometry Biotechnology Co., Ltd, Chengdu 611130, P. R. ChinaWeihai Marine Organism & Medical Technology Research Institute, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150006, P. R. ChinaWeihai Marine Organism & Medical Technology Research Institute, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150006, P. R. ChinaWeihai Marine Organism & Medical Technology Research Institute, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150006, P. R. ChinaWeihai Marine Organism & Medical Technology Research Institute, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150006, P. R. China; Sichuan Mass Spectrometry Biotechnology Co., Ltd, Chengdu 611130, P. R. China; Corresponding author.Cancer has become one of the major diseases threatening human health. Conventional therapies have great adverse effects and are prone to drug resistance, and novel therapies are expensive and cause a heavy burden to patients. Plant polysaccharide has become a research hotspot in the field of anti-tumor functional foods and pharmaceuticals due to its advantages of high efficiency and low toxicity. Studies have shown that plant polysaccharides have little toxic and side effects and are characterized by multiple perspectives and mechanisms, preventing the emergence of drug resistance. Its anti-cancer molecular mechanisms mainly include inhibiting tumor proliferation and tumor apoptosis, inducing autophagy, effecting cell cycle, inhibiting tumor angiogenesis, regulating epithelial-mesenchymal transition, tumor oxidative stress and immune regulation. Compared with existing cancer drugs, plant polysaccharides have become one of the research hotspots in the field of anti-tumor due to their safety and efficiency. In this context, this review searched the anti-cancer literature on plant polysaccharides published from 2020 to 2022. By comparing the advantages and disadvantages of current and traditional cancer treatment methods, the feasibility of plant polysaccharides as effective natural drugs for the treatment and prevention of cancer was further explored.http://www.sciencedirect.com/science/article/pii/S2666893923000622Terrestrial plant polysaccharidePhysicochemical propertiesCancerTherapeutic mechanism |
| spellingShingle | Hao Ju Chong Yu Xian-Dong Zhang Wei Liu Yan-Chao Wu Pi-Xian Gong Hai-Huang Li Yang Liu Hui-Jing Li Recent trends in anti-cancer activities of terrestrial plants-based polysaccharides: A review Carbohydrate Polymer Technologies and Applications Terrestrial plant polysaccharide Physicochemical properties Cancer Therapeutic mechanism |
| title | Recent trends in anti-cancer activities of terrestrial plants-based polysaccharides: A review |
| title_full | Recent trends in anti-cancer activities of terrestrial plants-based polysaccharides: A review |
| title_fullStr | Recent trends in anti-cancer activities of terrestrial plants-based polysaccharides: A review |
| title_full_unstemmed | Recent trends in anti-cancer activities of terrestrial plants-based polysaccharides: A review |
| title_short | Recent trends in anti-cancer activities of terrestrial plants-based polysaccharides: A review |
| title_sort | recent trends in anti cancer activities of terrestrial plants based polysaccharides a review |
| topic | Terrestrial plant polysaccharide Physicochemical properties Cancer Therapeutic mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2666893923000622 |
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