Nucleic Acid Ligands Based on Carbohydrates
Sequence-specific nucleic acid ligands are important tools in chemistry and molecular biology and are thought to possess a considerable pharmaceutical potential. An overview of the structurally and mechanistically diverse approaches in the field with an emphasis on carbohydrates will be pr...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
1996-06-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/2649 |
| _version_ | 1819280116719550464 |
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| author | Jürg Hunziker |
| author_facet | Jürg Hunziker |
| author_sort | Jürg Hunziker |
| collection | DOAJ |
| description |
Sequence-specific nucleic acid ligands are important tools in chemistry and molecular biology and are thought to possess a considerable pharmaceutical potential. An overview of the structurally and mechanistically diverse approaches in the field with an emphasis on carbohydrates will
be presented. Carbohydrates are just beginning to emerge as a novel class of nucleic acid binding compounds. The detailed study of the factors affecting the site-selectivity of some recently discovered antitumor antibiotics, e.g. calicheamicin, has shed a new light on the role thatoligosaccharides
may play in nucleic acid recognition. Understanding these factors may aid in the rational design of novel nucleic acid ligands and their therapeutic application.
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| first_indexed | 2024-12-24T00:38:41Z |
| format | Article |
| id | doaj.art-9ca4cb76dae54b00a118607c6014e1ad |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-12-24T00:38:41Z |
| publishDate | 1996-06-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-9ca4cb76dae54b00a118607c6014e1ad2022-12-21T17:24:02ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24241996-06-01506Nucleic Acid Ligands Based on CarbohydratesJürg Hunziker Sequence-specific nucleic acid ligands are important tools in chemistry and molecular biology and are thought to possess a considerable pharmaceutical potential. An overview of the structurally and mechanistically diverse approaches in the field with an emphasis on carbohydrates will be presented. Carbohydrates are just beginning to emerge as a novel class of nucleic acid binding compounds. The detailed study of the factors affecting the site-selectivity of some recently discovered antitumor antibiotics, e.g. calicheamicin, has shed a new light on the role thatoligosaccharides may play in nucleic acid recognition. Understanding these factors may aid in the rational design of novel nucleic acid ligands and their therapeutic application. https://www.chimia.ch/chimia/article/view/2649 |
| spellingShingle | Jürg Hunziker Nucleic Acid Ligands Based on Carbohydrates CHIMIA |
| title | Nucleic Acid Ligands Based on Carbohydrates |
| title_full | Nucleic Acid Ligands Based on Carbohydrates |
| title_fullStr | Nucleic Acid Ligands Based on Carbohydrates |
| title_full_unstemmed | Nucleic Acid Ligands Based on Carbohydrates |
| title_short | Nucleic Acid Ligands Based on Carbohydrates |
| title_sort | nucleic acid ligands based on carbohydrates |
| url | https://www.chimia.ch/chimia/article/view/2649 |
| work_keys_str_mv | AT jurghunziker nucleicacidligandsbasedoncarbohydrates |