Comparison of Laboratory Tests Applied for Diagnosing the SARS-CoV-2 Infection
Due to the highly contagious nature and severity of the respiratory diseases caused by COVID-19, economical and accurate tests are required to better monitor and prevent the spread of this contagion. As the structural and molecular properties of SARS-CoV-2 were being revealed during the early stage...
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| Format: | Article |
| Language: | English |
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The Korean Society for Clinical Laboratory Science
2022-06-01
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| Series: | Korean Journal of Clinical Laboratory Science |
| Subjects: | |
| Online Access: | http://www.kjcls.org/journal/view.html?doi=10.15324/kjcls.2022.54.2.79 |
| _version_ | 1797960211516882944 |
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| author | Chang-Gun Lee Dongsup Lee |
| author_facet | Chang-Gun Lee Dongsup Lee |
| author_sort | Chang-Gun Lee |
| collection | DOAJ |
| description | Due to the highly contagious nature and severity of the respiratory diseases caused by COVID-19, economical and accurate tests are required to better monitor and prevent the spread of this contagion. As the structural and molecular properties of SARS-CoV-2 were being revealed during the early stage of the COVID-19 pandemic, many manufacturers of COVID-19 diagnostic kits actively invested in the design, development, validation, verification, and implementation of diagnostic tests. Currently, diagnostic tests for SARS-CoV-2 are the most widely used and validated techniques for rapid antigen, and immuno-serological assays for specific IgG and IgM antibody tests and molecular diagnostic tests. Molecular diagnostic assays are the gold standard for direct detection of viral RNA in individuals suspected to be infected with SARS-CoV-2. Antibody-based serological tests are indirect tests applied to determine COVID-19 prevalence in the community and identify individuals who have obtained immunity. In the future, it is necessary to explore technical problems encountered in the early stages of global or regional outbreaks of pandemics and provide future directions for better diagnostic tests. This article evaluates the commercially available and FDA-approved molecular and immunological diagnostic assays and analyzes their performance characteristics. |
| first_indexed | 2024-04-11T00:42:46Z |
| format | Article |
| id | doaj.art-9ca5f887d2074fbe8e24bba2de4490c7 |
| institution | Directory Open Access Journal |
| issn | 1738-3544 |
| language | English |
| last_indexed | 2024-04-11T00:42:46Z |
| publishDate | 2022-06-01 |
| publisher | The Korean Society for Clinical Laboratory Science |
| record_format | Article |
| series | Korean Journal of Clinical Laboratory Science |
| spelling | doaj.art-9ca5f887d2074fbe8e24bba2de4490c72023-01-06T01:44:08ZengThe Korean Society for Clinical Laboratory ScienceKorean Journal of Clinical Laboratory Science1738-35442022-06-01542799410.15324/kjcls.2022.54.2.79kjcls.2022.54.2.79Comparison of Laboratory Tests Applied for Diagnosing the SARS-CoV-2 InfectionChang-Gun Lee0Dongsup Lee1Department of Medical Genetics, Ajou University School of Medicine, Suwon, KoreaDepartment of Clinical Laboratory Science, Hyejeon College, Hongseong, KoreaDue to the highly contagious nature and severity of the respiratory diseases caused by COVID-19, economical and accurate tests are required to better monitor and prevent the spread of this contagion. As the structural and molecular properties of SARS-CoV-2 were being revealed during the early stage of the COVID-19 pandemic, many manufacturers of COVID-19 diagnostic kits actively invested in the design, development, validation, verification, and implementation of diagnostic tests. Currently, diagnostic tests for SARS-CoV-2 are the most widely used and validated techniques for rapid antigen, and immuno-serological assays for specific IgG and IgM antibody tests and molecular diagnostic tests. Molecular diagnostic assays are the gold standard for direct detection of viral RNA in individuals suspected to be infected with SARS-CoV-2. Antibody-based serological tests are indirect tests applied to determine COVID-19 prevalence in the community and identify individuals who have obtained immunity. In the future, it is necessary to explore technical problems encountered in the early stages of global or regional outbreaks of pandemics and provide future directions for better diagnostic tests. This article evaluates the commercially available and FDA-approved molecular and immunological diagnostic assays and analyzes their performance characteristics.http://www.kjcls.org/journal/view.html?doi=10.15324/kjcls.2022.54.2.79laboratory testsmolecular diagnostics testsrt-qpcrsars-cov-2serological assays |
| spellingShingle | Chang-Gun Lee Dongsup Lee Comparison of Laboratory Tests Applied for Diagnosing the SARS-CoV-2 Infection Korean Journal of Clinical Laboratory Science laboratory tests molecular diagnostics tests rt-qpcr sars-cov-2 serological assays |
| title | Comparison of Laboratory Tests Applied for Diagnosing the SARS-CoV-2 Infection |
| title_full | Comparison of Laboratory Tests Applied for Diagnosing the SARS-CoV-2 Infection |
| title_fullStr | Comparison of Laboratory Tests Applied for Diagnosing the SARS-CoV-2 Infection |
| title_full_unstemmed | Comparison of Laboratory Tests Applied for Diagnosing the SARS-CoV-2 Infection |
| title_short | Comparison of Laboratory Tests Applied for Diagnosing the SARS-CoV-2 Infection |
| title_sort | comparison of laboratory tests applied for diagnosing the sars cov 2 infection |
| topic | laboratory tests molecular diagnostics tests rt-qpcr sars-cov-2 serological assays |
| url | http://www.kjcls.org/journal/view.html?doi=10.15324/kjcls.2022.54.2.79 |
| work_keys_str_mv | AT changgunlee comparisonoflaboratorytestsappliedfordiagnosingthesarscov2infection AT dongsuplee comparisonoflaboratorytestsappliedfordiagnosingthesarscov2infection |