UJI AKTIVITAS ANTIDIABETES AKAR KAYU KUNING (ARCANGELISIA FLAVA)
This study used extracts of Arcangelisia flava root to see its potential as an antidiabetic activity that can reduce blood glucose levels in male wistar mice induced by alloxan.The study design was an in vivo experimental study with a post test with control group design approach. The samples were...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Indonesian |
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Universitas Sriwijaya
2020-10-01
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| Series: | Jurnal Kedokteran dan Kesehatan |
| Online Access: | https://ejournal.unsri.ac.id/index.php/jkk/article/view/10190 |
| _version_ | 1811305714970263552 |
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| author | Fatmawati Karim Susilawati Susilawati Liniyati D Oswari Dzakiyah Dzakiyah Fahira Anindita |
| author_facet | Fatmawati Karim Susilawati Susilawati Liniyati D Oswari Dzakiyah Dzakiyah Fahira Anindita |
| author_sort | Fatmawati Karim |
| collection | DOAJ |
| description | This study used extracts of Arcangelisia flava root to see its potential as an antidiabetic activity that can reduce blood glucose levels in male wistar mice induced by alloxan.The study design was an in vivo experimental study with a post test with control group design approach. The samples were 70 male wistar mice divided randomly into 14 treatmen groups, which every group contained five rats : negative control (NaCMC 0.5%), positive control (acarbose 4.5 mg / kgBW), hexane extract of Arcangelisia flava root (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW), ethyl acetate extract of Arcangelisia flava root (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW), ethanol extract of Arcangelisia flava root (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW), and aquadest extract of Arcangelisia flava root (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW). All treatmen groups were subjected to alloxan induction to reach a glucose level af approximately 200 mg/dL (pretest). After 15 days, a measurement of blood glucose (posttest) was taken. The results showed that ethanol extract 750 mg/kgBW, ethyl acetate extract (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW) and aquadest extract (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW) have the ability to reduce blood glucose and only ethyl acetate dose 750 mg/kgBW, aquadest extract dose 500 mg/kgBW and 750 mg/kgBW can reduce blood glucose likely acarbose. Phytochemical tests found the presence of alkaloids and flavonoids in ethanol extract, ethyl acetate extract and aquadest extract, but tannin contained only in ethanol extract and ethyl acetate extract. |
| first_indexed | 2024-04-13T08:31:20Z |
| format | Article |
| id | doaj.art-9ca6d964163c460cad6808ec879421d4 |
| institution | Directory Open Access Journal |
| issn | 2406-7431 2614-0411 |
| language | Indonesian |
| last_indexed | 2024-04-13T08:31:20Z |
| publishDate | 2020-10-01 |
| publisher | Universitas Sriwijaya |
| record_format | Article |
| series | Jurnal Kedokteran dan Kesehatan |
| spelling | doaj.art-9ca6d964163c460cad6808ec879421d42022-12-22T02:54:15ZindUniversitas SriwijayaJurnal Kedokteran dan Kesehatan2406-74312614-04112020-10-017318919410.32539/JKK.V7I3.101905341UJI AKTIVITAS ANTIDIABETES AKAR KAYU KUNING (ARCANGELISIA FLAVA)Fatmawati Karim0Susilawati Susilawati1Liniyati D Oswari2Dzakiyah Dzakiyah3Fahira Anindita4Universitas SriwijayaUniversitas SriwijayaUniversitas SriwijayaUniversitas SriwijayaUniversitas SriwijayaThis study used extracts of Arcangelisia flava root to see its potential as an antidiabetic activity that can reduce blood glucose levels in male wistar mice induced by alloxan.The study design was an in vivo experimental study with a post test with control group design approach. The samples were 70 male wistar mice divided randomly into 14 treatmen groups, which every group contained five rats : negative control (NaCMC 0.5%), positive control (acarbose 4.5 mg / kgBW), hexane extract of Arcangelisia flava root (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW), ethyl acetate extract of Arcangelisia flava root (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW), ethanol extract of Arcangelisia flava root (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW), and aquadest extract of Arcangelisia flava root (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW). All treatmen groups were subjected to alloxan induction to reach a glucose level af approximately 200 mg/dL (pretest). After 15 days, a measurement of blood glucose (posttest) was taken. The results showed that ethanol extract 750 mg/kgBW, ethyl acetate extract (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW) and aquadest extract (dose 250 mg/kgBW, 500 mg/kgBW and 750 mg/kgBW) have the ability to reduce blood glucose and only ethyl acetate dose 750 mg/kgBW, aquadest extract dose 500 mg/kgBW and 750 mg/kgBW can reduce blood glucose likely acarbose. Phytochemical tests found the presence of alkaloids and flavonoids in ethanol extract, ethyl acetate extract and aquadest extract, but tannin contained only in ethanol extract and ethyl acetate extract.https://ejournal.unsri.ac.id/index.php/jkk/article/view/10190 |
| spellingShingle | Fatmawati Karim Susilawati Susilawati Liniyati D Oswari Dzakiyah Dzakiyah Fahira Anindita UJI AKTIVITAS ANTIDIABETES AKAR KAYU KUNING (ARCANGELISIA FLAVA) Jurnal Kedokteran dan Kesehatan |
| title | UJI AKTIVITAS ANTIDIABETES AKAR KAYU KUNING (ARCANGELISIA FLAVA) |
| title_full | UJI AKTIVITAS ANTIDIABETES AKAR KAYU KUNING (ARCANGELISIA FLAVA) |
| title_fullStr | UJI AKTIVITAS ANTIDIABETES AKAR KAYU KUNING (ARCANGELISIA FLAVA) |
| title_full_unstemmed | UJI AKTIVITAS ANTIDIABETES AKAR KAYU KUNING (ARCANGELISIA FLAVA) |
| title_short | UJI AKTIVITAS ANTIDIABETES AKAR KAYU KUNING (ARCANGELISIA FLAVA) |
| title_sort | uji aktivitas antidiabetes akar kayu kuning arcangelisia flava |
| url | https://ejournal.unsri.ac.id/index.php/jkk/article/view/10190 |
| work_keys_str_mv | AT fatmawatikarim ujiaktivitasantidiabetesakarkayukuningarcangelisiaflava AT susilawatisusilawati ujiaktivitasantidiabetesakarkayukuningarcangelisiaflava AT liniyatidoswari ujiaktivitasantidiabetesakarkayukuningarcangelisiaflava AT dzakiyahdzakiyah ujiaktivitasantidiabetesakarkayukuningarcangelisiaflava AT fahiraanindita ujiaktivitasantidiabetesakarkayukuningarcangelisiaflava |